HK1220201A1 - 作爲成像工具的咪唑並 吡啶- -胺類 - Google Patents
作爲成像工具的咪唑並 吡啶- -胺類Info
- Publication number
- HK1220201A1 HK1220201A1 HK16108347.5A HK16108347A HK1220201A1 HK 1220201 A1 HK1220201 A1 HK 1220201A1 HK 16108347 A HK16108347 A HK 16108347A HK 1220201 A1 HK1220201 A1 HK 1220201A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- imidazo
- pyridin
- amines
- imaging tools
- tools
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title 1
- IHFZRBQSSDQVOD-UHFFFAOYSA-N imidazo[1,2-a]pyridin-7-amine Chemical class C1=C(N)C=CN2C=CN=C21 IHFZRBQSSDQVOD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13186074 | 2013-09-26 | ||
PCT/EP2014/070162 WO2015044095A1 (en) | 2013-09-26 | 2014-09-23 | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1220201A1 true HK1220201A1 (zh) | 2017-04-28 |
Family
ID=49230646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16108347.5A HK1220201A1 (zh) | 2013-09-26 | 2016-07-15 | 作爲成像工具的咪唑並 吡啶- -胺類 |
Country Status (12)
Country | Link |
---|---|
US (1) | US9957266B2 (zh) |
EP (1) | EP3049411B1 (zh) |
JP (1) | JP6182668B2 (zh) |
KR (1) | KR101770532B1 (zh) |
CN (1) | CN105579453B (zh) |
AR (1) | AR097739A1 (zh) |
CA (1) | CA2920068A1 (zh) |
HK (1) | HK1220201A1 (zh) |
MX (1) | MX2016003422A (zh) |
RU (1) | RU2671506C2 (zh) |
TW (1) | TWI518087B (zh) |
WO (1) | WO2015044095A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2991983T3 (en) * | 2013-04-29 | 2017-05-08 | Hoffmann La Roche | 2-PHENYL OR 2-HETARYLIMIDAZOLE [1,2-a] PYRIDINE DERIVATIVES |
WO2016033440A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
US10865207B2 (en) | 2016-07-22 | 2020-12-15 | Ac Immune S.A. | Compounds for imaging Tau protein aggregates |
JP7197476B2 (ja) | 2016-07-22 | 2022-12-27 | エーシー・イミューン・エス・アー | タウタンパク質凝集体を画像化するための化合物 |
EP3652329B1 (en) * | 2017-07-12 | 2023-10-04 | Dana-Farber Cancer Institute, Inc. | Compounds for tau protein degradation |
WO2019145292A1 (en) | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Azacarboline compounds for the detection of tau aggregates |
EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA62972C2 (en) * | 1997-07-03 | 2004-01-15 | Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders | |
GB9927687D0 (en) * | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
AU8670201A (en) | 2000-08-24 | 2002-03-04 | Univ Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
AU2002258915B2 (en) * | 2001-04-23 | 2007-11-15 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
AU2002323417B2 (en) | 2001-08-27 | 2008-05-15 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
AU2004221897B2 (en) * | 2003-03-14 | 2010-11-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Benzothiazole derivative compounds, compositions and uses |
CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
US20070031328A1 (en) * | 2005-06-24 | 2007-02-08 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
EP1956013B1 (en) | 2005-11-30 | 2016-04-13 | Fujifilm RI Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
JP2010516672A (ja) * | 2007-01-22 | 2010-05-20 | アストラゼネカ・アクチエボラーグ | 新規なヘテロアリール置換されたイミダゾ[1,2−a]ピリジン誘導体 |
EP2172444A4 (en) * | 2007-07-04 | 2010-12-22 | Univ Tohoku | PET SENSOR HAVING ALCOXY GROUP SUBSTITUTED BY FLUORIN ATOM AND HYDROXY GROUP |
US20100267952A1 (en) * | 2007-10-30 | 2010-10-21 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
SI2338059T1 (sl) * | 2008-09-23 | 2015-08-31 | Wista Laboratories Ltd. | Ligandi za agregirane molekule tau |
US8691187B2 (en) * | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
DK2480546T3 (en) | 2009-09-24 | 2015-02-02 | Hoffmann La Roche | Imidazopyridine or imidazopyrimidinderivater as phosphodiesterase inhibitors 10A |
US8410117B2 (en) * | 2010-03-26 | 2013-04-02 | Hoffmann-La Roche Inc. | Imidazopyrimidine derivatives |
DK2991983T3 (en) | 2013-04-29 | 2017-05-08 | Hoffmann La Roche | 2-PHENYL OR 2-HETARYLIMIDAZOLE [1,2-a] PYRIDINE DERIVATIVES |
-
2014
- 2014-09-23 MX MX2016003422A patent/MX2016003422A/es unknown
- 2014-09-23 RU RU2016112547A patent/RU2671506C2/ru not_active IP Right Cessation
- 2014-09-23 JP JP2016517347A patent/JP6182668B2/ja active Active
- 2014-09-23 CA CA2920068A patent/CA2920068A1/en not_active Abandoned
- 2014-09-23 CN CN201480053175.7A patent/CN105579453B/zh active Active
- 2014-09-23 KR KR1020167008021A patent/KR101770532B1/ko active IP Right Grant
- 2014-09-23 WO PCT/EP2014/070162 patent/WO2015044095A1/en active Application Filing
- 2014-09-23 EP EP14771582.5A patent/EP3049411B1/en active Active
- 2014-09-24 AR ARP140103520A patent/AR097739A1/es unknown
- 2014-09-25 TW TW103133334A patent/TWI518087B/zh not_active IP Right Cessation
-
2016
- 2016-03-25 US US15/081,002 patent/US9957266B2/en active Active
- 2016-07-15 HK HK16108347.5A patent/HK1220201A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN105579453A (zh) | 2016-05-11 |
TWI518087B (zh) | 2016-01-21 |
US20160207919A1 (en) | 2016-07-21 |
RU2016112547A3 (zh) | 2018-05-25 |
US9957266B2 (en) | 2018-05-01 |
MX2016003422A (es) | 2016-06-28 |
AR097739A1 (es) | 2016-04-13 |
CA2920068A1 (en) | 2015-04-02 |
KR20160048166A (ko) | 2016-05-03 |
EP3049411B1 (en) | 2017-04-26 |
TW201516046A (zh) | 2015-05-01 |
KR101770532B1 (ko) | 2017-08-22 |
JP6182668B2 (ja) | 2017-08-16 |
EP3049411A1 (en) | 2016-08-03 |
WO2015044095A1 (en) | 2015-04-02 |
RU2671506C2 (ru) | 2018-11-01 |
RU2016112547A (ru) | 2017-10-31 |
JP2016533334A (ja) | 2016-10-27 |
CN105579453B (zh) | 2017-12-22 |
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