HK1219979A1 - '- 用於植物的重組蛋白的過度表達的具有最佳的 '- 前導區功能的人工 序列和産生植物的重組蛋白的方法 - Google Patents

'- 用於植物的重組蛋白的過度表達的具有最佳的 '- 前導區功能的人工 序列和産生植物的重組蛋白的方法

Info

Publication number
HK1219979A1
HK1219979A1 HK16108044.1A HK16108044A HK1219979A1 HK 1219979 A1 HK1219979 A1 HK 1219979A1 HK 16108044 A HK16108044 A HK 16108044A HK 1219979 A1 HK1219979 A1 HK 1219979A1
Authority
HK
Hong Kong
Prior art keywords
utr
plants
recombinant proteins
expression
production
Prior art date
Application number
HK16108044.1A
Other languages
English (en)
Inventor
斯特凡諾．馬爾凱蒂
塔瑪拉．帕蒂
艾瑞卡．塞科
Original Assignee
Rodina Holding S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rodina Holding S A filed Critical Rodina Holding S A
Publication of HK1219979A1 publication Critical patent/HK1219979A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
HK16108044.1A 2013-01-16 2016-07-11 '- 用於植物的重組蛋白的過度表達的具有最佳的 '- 前導區功能的人工 序列和産生植物的重組蛋白的方法 HK1219979A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000002A ITUD20130002A1 (it) 2013-01-16 2013-01-16 Sequenza artificiale di dna avente funzione di leader in 5' (5'-utr) ottimizzata per la sovraespressione di proteine ricombinanti in pianta e metodo per la produzione di proteine ricombinanti in pianta
PCT/IB2014/058289 WO2014111858A1 (en) 2013-01-16 2014-01-15 Artificial dna sequence with optimized leader function in 5' (5'-utr) for the over-expression of recombinant proteins in plants and method for the production of recombinant proteins in plants

Publications (1)

Publication Number Publication Date
HK1219979A1 true HK1219979A1 (zh) 2017-04-21

Family

ID=47749983

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108044.1A HK1219979A1 (zh) 2013-01-16 2016-07-11 '- 用於植物的重組蛋白的過度表達的具有最佳的 '- 前導區功能的人工 序列和産生植物的重組蛋白的方法

Country Status (15)

Country Link
US (1) US9976151B2 (zh)
EP (1) EP2946017B1 (zh)
JP (1) JP6369839B2 (zh)
KR (1) KR20150113013A (zh)
CN (1) CN105247057B (zh)
BR (1) BR112015016973A2 (zh)
CA (1) CA2898388A1 (zh)
ES (1) ES2627490T3 (zh)
HK (1) HK1219979A1 (zh)
HU (1) HUE033589T2 (zh)
IL (1) IL239956B (zh)
IT (1) ITUD20130002A1 (zh)
PL (1) PL2946017T3 (zh)
SA (1) SA515360791B1 (zh)
WO (1) WO2014111858A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700042052A1 (it) * 2017-04-14 2018-10-14 Transactiva S R L Vettore di espressione e metodo per la produzione di una proteina umana in pianta, in particolare un anticorpo ricombinante in endosperma di cereale
ES2952779T3 (es) 2017-05-18 2023-11-06 Modernatx Inc ARN mensajero modificado que comprende elementos de ARN funcionales
IT202100022157A1 (it) 2021-08-20 2023-02-20 Transactiva S R L Promotore sintetico per l’espressione di proteine eterologhe in pianta

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206016D0 (en) * 1992-03-19 1992-04-29 Sandoz Ltd Improvements in or relating to organic compounds
CN1164755C (zh) * 2001-09-05 2004-09-01 南京大学 一种改善外源基因在大肠杆菌中可溶性表达的方法
ITUD20060280A1 (it) * 2006-12-29 2008-06-30 Univ Degli Studi Udine Sequenza artificiale di dna evente funzione di leader in 5' (5'-utr) ottimizzata per la sovraespressione di proteine eterologhe in pianta
ITUD20080055A1 (it) * 2008-03-13 2009-09-14 Transactiva S R L Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali

Also Published As

Publication number Publication date
JP6369839B2 (ja) 2018-08-15
PL2946017T3 (pl) 2017-09-29
CA2898388A1 (en) 2014-07-24
CN105247057A (zh) 2016-01-13
ES2627490T3 (es) 2017-07-28
EP2946017B1 (en) 2017-03-01
US9976151B2 (en) 2018-05-22
SA515360791B1 (ar) 2017-11-07
EP2946017A1 (en) 2015-11-25
CN105247057B (zh) 2018-11-02
US20160130593A1 (en) 2016-05-12
KR20150113013A (ko) 2015-10-07
BR112015016973A2 (pt) 2021-08-03
JP2016502864A (ja) 2016-02-01
IL239956A0 (en) 2015-08-31
HUE033589T2 (hu) 2017-12-28
WO2014111858A1 (en) 2014-07-24
IL239956B (en) 2018-08-30
ITUD20130002A1 (it) 2014-07-17

Similar Documents

Publication Publication Date Title
HK1252643A1 (zh) 使用融合蛋白對tcr重編程的組合物和方法
IL264193B1 (en) Methods and systems for growing cells in culture
ZA201800561B (en) Plant derived insecticidal proteins and methods for their use
ZA201601699B (en) Plant growth regulating composition and methods for making and using same
EP2968551A4 (en) FUSION PROTEINS AND METHOD THEREFOR
EP3043635A4 (en) Insecticidal proteins and methods for their use
EP3032942A4 (en) Insecticidal proteins and methods for their use
EP2943253A4 (en) COMPOSITIONS AND METHODS FOR REGULATING T REGULATORY LYMPHOCYTES USING A TL1A-IG FUSION PROTEIN
IL263779A (en) Protein production in plant cells
HK1208144A1 (zh) 人工生物心臟瓣膜及其製作方法
HK1208629A1 (zh) 融合蛋白及其在治療生長激素缺乏中的用途
EP3193164A4 (en) Artificial defect material and method for manufacturing frp structure
EP3029072A4 (en) Glp-1 analog fusion protein and preparation method and use thereof
HK1206762A1 (zh) 具有低或無苯丙氨酸的營養性片段、蛋白質和方法
EP3008993A4 (en) Method for inducing artificial ovulation and spawning of fresh-water eels
WO2014140927A3 (en) Proteins with modified glycosylation and methods of production thereof
SG11201707858TA (en) Human serum albumin-containing culture medium for growth of neural stem cells
IL269197A (en) Control of fully apocosylated antibody glycoforms produced in cell culture
EP3686274A4 (en) METHOD OF MANUFACTURING A NATURAL KILLER CELL AND USE THEREOF
IL234683B (en) Fusion proteins containing toso protein and a method for their production
ZA201508661B (en) Antifungal plant proteins, peptides, and methods of use
EP3235831A4 (en) Artificial multi-antigen fusion protein and preparation and use thereof
HK1219979A1 (zh) '- 用於植物的重組蛋白的過度表達的具有最佳的 '- 前導區功能的人工 序列和産生植物的重組蛋白的方法
EP3064576A4 (en) POLYPEPTIDE COMPOSITION AND METHOD FOR CULTURING PLURIPOTENT STEM CELLS USING THE SAME
EP3008188A4 (en) Protein production in plants

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230120