HK1212679A1 - 他唑巴坦的製作工藝 - Google Patents

他唑巴坦的製作工藝 Download PDF

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Publication number
HK1212679A1
HK1212679A1 HK16100491.6A HK16100491A HK1212679A1 HK 1212679 A1 HK1212679 A1 HK 1212679A1 HK 16100491 A HK16100491 A HK 16100491A HK 1212679 A1 HK1212679 A1 HK 1212679A1
Authority
HK
Hong Kong
Prior art keywords
tazobactam
preparation
cresol
formula
relates
Prior art date
Application number
HK16100491.6A
Other languages
English (en)
Chinese (zh)
Inventor
Venugopal Sivasankaran
Anandan Sakthivel
Udayampalayam Palanisamy Senthilkumar
Rajamanickam Kannadhasan
VELRAJ Loganathan
Singaravel Mohan
Original Assignee
Hospira, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospira, Inc. filed Critical Hospira, Inc.
Publication of HK1212679A1 publication Critical patent/HK1212679A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/06—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HK16100491.6A 2012-09-06 2013-09-05 他唑巴坦的製作工藝 HK1212679A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH00369012 2012-09-06
IN3690CH2012 2012-09-06
PCT/IB2013/058306 WO2014037893A1 (en) 2012-09-06 2013-09-05 Process for the preparation of tazobactam

Publications (1)

Publication Number Publication Date
HK1212679A1 true HK1212679A1 (zh) 2016-06-17

Family

ID=50236609

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100491.6A HK1212679A1 (zh) 2012-09-06 2013-09-05 他唑巴坦的製作工藝

Country Status (5)

Country Link
US (1) US20150246931A1 (en:Method)
EP (1) EP2892903A4 (en:Method)
HK (1) HK1212679A1 (en:Method)
IN (1) IN2015DN02444A (en:Method)
WO (1) WO2014037893A1 (en:Method)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107033161B (zh) * 2017-05-04 2019-01-01 石家庄万业化工科技有限公司 一种他唑巴坦酸的合成方法
CN107941977B (zh) * 2017-11-23 2020-05-15 淄博鑫泉医药技术服务有限公司 他唑巴坦中间产物他唑巴坦二苯甲酯的高效液相分析方法
CN108912143A (zh) * 2018-08-29 2018-11-30 上海晋景化学有限公司 一种他唑巴坦二苯甲酯中间体的制备方法
CN111004231A (zh) * 2019-12-18 2020-04-14 凯莱英医药集团（天津）股份有限公司 他唑巴坦中间体的连续合成方法
CN114031629A (zh) * 2021-12-10 2022-02-11 山东安舜制药有限公司 一种合成他唑巴坦中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3306473B1 (ja) * 2001-05-01 2002-07-24 大塚化学株式会社 β−ラクタム化合物の無水結晶及びその製造法
TW200519119A (en) * 2003-10-10 2005-06-16 Otsuka Chemical Co Ltd PENAM crystal and process for producing the same
CN102643292B (zh) * 2012-05-02 2014-04-30 齐鲁天和惠世制药有限公司 一种他唑巴坦的合成方法

Also Published As

Publication number Publication date
IN2015DN02444A (en:Method) 2015-09-04
WO2014037893A1 (en) 2014-03-13
EP2892903A4 (en) 2016-01-27
US20150246931A1 (en) 2015-09-03
EP2892903A1 (en) 2015-07-15

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