HK1212384A1 - 用於生產誘導肝細胞的方法和組合物 - Google Patents

用於生產誘導肝細胞的方法和組合物

Info

Publication number
HK1212384A1
HK1212384A1 HK16100277.6A HK16100277A HK1212384A1 HK 1212384 A1 HK1212384 A1 HK 1212384A1 HK 16100277 A HK16100277 A HK 16100277A HK 1212384 A1 HK1212384 A1 HK 1212384A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
producing induced
induced hepatocytes
hepatocytes
Prior art date
Application number
HK16100277.6A
Other languages
English (en)
Inventor
Kamen P Simeonov
Hirdesh Uppal
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1212384A1 publication Critical patent/HK1212384A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/27—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from lung cells, from cells of the respiratory tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK16100277.6A 2012-09-07 2016-01-12 用於生產誘導肝細胞的方法和組合物 HK1212384A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698359P 2012-09-07 2012-09-07
US201361777973P 2013-03-12 2013-03-12
PCT/US2013/058414 WO2014039768A1 (en) 2012-09-07 2013-09-06 Methods and compositions for producing induced hepatocytes

Publications (1)

Publication Number Publication Date
HK1212384A1 true HK1212384A1 (zh) 2016-06-10

Family

ID=49209556

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100277.6A HK1212384A1 (zh) 2012-09-07 2016-01-12 用於生產誘導肝細胞的方法和組合物

Country Status (15)

Country Link
US (2) US20140087416A1 (zh)
EP (1) EP2892999A1 (zh)
JP (1) JP2015527084A (zh)
KR (1) KR20150052228A (zh)
CN (1) CN104781393A (zh)
AU (1) AU2013312440A1 (zh)
BR (1) BR112015005011A2 (zh)
CA (1) CA2883714A1 (zh)
HK (1) HK1212384A1 (zh)
IL (1) IL237433A0 (zh)
MX (1) MX2015002917A (zh)
RU (1) RU2015107036A (zh)
SG (1) SG11201501681SA (zh)
WO (1) WO2014039768A1 (zh)
ZA (1) ZA201501435B (zh)

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US9023612B2 (en) 2012-01-13 2015-05-05 Bell Biosystems, Inc. Eukaryotic cells with artificial endosymbionts for multimodal detection
US8956873B2 (en) 2012-01-13 2015-02-17 Bell Biosystems, Inc. Host cells with artificial endosymbionts
US10076579B2 (en) 2012-01-13 2018-09-18 Bell Biosystems, Inc. Host cells with artificial endosymbionts
US8828681B2 (en) 2012-01-13 2014-09-09 Bell Biosystems, Inc. Host cells with artificial endosymbionts
CN103981147B (zh) * 2013-02-08 2017-11-10 中国科学院上海生命科学研究院 一种新的制备肝实质细胞的方法
US9481869B2 (en) 2013-09-03 2016-11-01 Bell Biosystems, Inc. Host cell modification with artificial endosymbionts
CN104830906B (zh) 2014-02-12 2018-09-04 北京维通达生物技术有限公司 一种重编程获得功能性人肝脏实质细胞的方法
US20170107486A1 (en) * 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
CN106572974B (zh) 2014-07-15 2021-04-23 生命技术公司 用于将分子有效递送到细胞的具有脂质聚集体的组合物和方法
WO2016054298A1 (en) * 2014-10-01 2016-04-07 Bell Biosystems, Inc. Magnetogenetics
EP3359169A4 (en) * 2015-10-05 2019-03-13 Orig3N, Inc. DIAGNOSIS AND TREATMENT OF MORBUS PARKINSON BASED ON THE IDENTIFICATION AND REDUCTION OF LIVER FUNCTIONAL DISORDERS
RU2018146815A (ru) * 2016-06-03 2020-07-10 Стемдженикс, Инк. Прямое перепрограммировние соматических клеток человека в направлении выбранной (предопределенной) дифференцированной клетки с использованием функционализированных наночпстиц
US11732240B2 (en) * 2016-07-28 2023-08-22 Unist (Ulsan National Institute Of Science And Technology) Direct conversion method of somatic cell into Hepatic stem cell, hepatic cell, or cholangiocyte
JP2019535272A (ja) * 2016-11-16 2019-12-12 アリール バイオテクノロジー アンド ファーマシューティカルズ， インコーポレイテッド Ｒｎａでの幹細胞分化による肝細胞の誘導
EP3808380A1 (en) * 2016-12-08 2021-04-21 CureVac AG Rna for treatment or prophylaxis of a liver disease
EP3562845A2 (en) 2016-12-27 2019-11-06 H. Hoffnabb-La Roche Ag Novel biotin-specific monoclonal antibody and use thereof
CN109504650A (zh) * 2017-09-15 2019-03-22 海门雨霖细胞科技有限责任公司 小分子诱导人成纤维细胞直接重编程为肝细胞的方法
EP3702449A4 (en) * 2017-10-23 2021-07-28 Kyushu University, National University Corporation METHOD FOR PRODUCING LIVER STEM CELLS OR LIVER ANALYZER CELLS BY DIRECT REPROGRAMMING
WO2020138208A1 (ja) * 2018-12-26 2020-07-02 国立大学法人京都大学 肝細胞の製造方法
US20220110979A1 (en) * 2019-01-11 2022-04-14 Figene, Llc Fibroblast regenerative cells
EP3931304A4 (en) * 2019-02-26 2022-10-19 Peking University COMPOSITIONS AND METHODS FOR REPROGRAMMING NON-HEPATOCYTIC CELLS INTO HEPATOCYTIC CELLS
CN114085874B (zh) * 2022-01-10 2022-04-29 广东乾晖生物科技有限公司 一种制备肝功能可逆的永生化肝细胞的方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
PL2578685T3 (pl) 2005-08-23 2020-01-31 The Trustees Of The University Of Pennsylvania Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US8062632B2 (en) * 2008-06-23 2011-11-22 National Yang-Ming University Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof
EP2510099B1 (en) 2009-12-07 2017-08-09 The Trustees Of The University Of Pennsylvania Rna preparations comprising purified modified rna for reprogramming cells
JPWO2011102532A1 (ja) * 2010-02-16 2013-06-17 国立大学法人九州大学 誘導肝細胞
CA2796251C (en) * 2010-04-13 2019-05-14 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
CN102465115B (zh) * 2010-11-04 2014-03-05 中国科学院上海生命科学研究院 一种新的制备肝实质细胞的方法
CN102286535B (zh) * 2011-06-17 2013-06-05 中国人民解放军第二军医大学 一种成纤维细胞转分化为肝干细胞的方法

Also Published As

Publication number Publication date
IL237433A0 (en) 2015-04-30
AU2013312440A1 (en) 2015-03-19
BR112015005011A2 (pt) 2018-04-17
KR20150052228A (ko) 2015-05-13
SG11201501681SA (en) 2015-04-29
WO2014039768A1 (en) 2014-03-13
CN104781393A (zh) 2015-07-15
JP2015527084A (ja) 2015-09-17
MX2015002917A (es) 2015-06-03
CA2883714A1 (en) 2014-03-13
US20140087416A1 (en) 2014-03-27
RU2015107036A (ru) 2016-10-27
ZA201501435B (en) 2017-09-27
EP2892999A1 (en) 2015-07-15
US20150376570A1 (en) 2015-12-31

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