SG11201501681SA - Methods and compositions for producing induced hepatocytes - Google Patents

Methods and compositions for producing induced hepatocytes

Info

Publication number
SG11201501681SA
SG11201501681SA SG11201501681SA SG11201501681SA SG11201501681SA SG 11201501681S A SG11201501681S A SG 11201501681SA SG 11201501681S A SG11201501681S A SG 11201501681SA SG 11201501681S A SG11201501681S A SG 11201501681SA SG 11201501681S A SG11201501681S A SG 11201501681SA
Authority
SG
Singapore
Prior art keywords
compositions
methods
producing induced
induced hepatocytes
hepatocytes
Prior art date
Application number
SG11201501681SA
Inventor
Kamen P Simeonov
Hirdesh Uppal
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG11201501681SA publication Critical patent/SG11201501681SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/27—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from lung cells, from cells of the respiratory tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201501681SA 2012-09-07 2013-09-06 Methods and compositions for producing induced hepatocytes SG11201501681SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698359P 2012-09-07 2012-09-07
US201361777973P 2013-03-12 2013-03-12
PCT/US2013/058414 WO2014039768A1 (en) 2012-09-07 2013-09-06 Methods and compositions for producing induced hepatocytes

Publications (1)

Publication Number Publication Date
SG11201501681SA true SG11201501681SA (en) 2015-04-29

Family

ID=49209556

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201501681SA SG11201501681SA (en) 2012-09-07 2013-09-06 Methods and compositions for producing induced hepatocytes

Country Status (15)

Country Link
US (2) US20140087416A1 (en)
EP (1) EP2892999A1 (en)
JP (1) JP2015527084A (en)
KR (1) KR20150052228A (en)
CN (1) CN104781393A (en)
AU (1) AU2013312440A1 (en)
BR (1) BR112015005011A2 (en)
CA (1) CA2883714A1 (en)
HK (1) HK1212384A1 (en)
IL (1) IL237433A0 (en)
MX (1) MX2015002917A (en)
RU (1) RU2015107036A (en)
SG (1) SG11201501681SA (en)
WO (1) WO2014039768A1 (en)
ZA (1) ZA201501435B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8828681B2 (en) 2012-01-13 2014-09-09 Bell Biosystems, Inc. Host cells with artificial endosymbionts
US9023612B2 (en) 2012-01-13 2015-05-05 Bell Biosystems, Inc. Eukaryotic cells with artificial endosymbionts for multimodal detection
US10076579B2 (en) 2012-01-13 2018-09-18 Bell Biosystems, Inc. Host cells with artificial endosymbionts
US8956873B2 (en) 2012-01-13 2015-02-17 Bell Biosystems, Inc. Host cells with artificial endosymbionts
CN103981147B (en) * 2013-02-08 2017-11-10 中国科学院上海生命科学研究院 A kind of new method for preparing hepatic parenchymal cells
SG11201601488VA (en) 2013-09-03 2016-03-30 Bell Biosystems Inc Host cell modification with artificial endosymbionts
CN104830906B (en) 2014-02-12 2018-09-04 北京维通达生物技术有限公司 Method for obtaining functional human liver parenchymal cells by reprogramming
WO2015164228A1 (en) * 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
CN106572974B (en) 2014-07-15 2021-04-23 生命技术公司 Compositions and methods having lipid aggregates for efficient delivery of molecules to cells
WO2016054298A1 (en) * 2014-10-01 2016-04-07 Bell Biosystems, Inc. Magnetogenetics
KR20180055901A (en) 2015-10-05 2018-05-25 오리그3엔, 인코포레이티드 Diagnosis and treatment of Parkinson's disease based on identification and improvement of liver dysfunction
US20190224335A1 (en) * 2016-06-03 2019-07-25 Stemgenics, Inc. Direct reprogramming of a human somatic cell to a selected (predetermined) differentiated cell with functionalized nanoparticles
KR101967435B1 (en) * 2016-07-28 2019-04-09 울산과학기술원 Composition for inducing direct conversion of somatic cell into hepatic stem cell, hepatic cell, or cholangiocyte
CA3043368A1 (en) * 2016-11-16 2018-05-24 Allele Biotechnology & Pharmaceuticals, Inc. Induction of hepatocytes by stem cell differentiation with rna
WO2018104538A1 (en) * 2016-12-08 2018-06-14 Curevac Ag Rna for treatment or prophylaxis of a liver disease
KR20210126136A (en) 2016-12-27 2021-10-19 에프. 호프만-라 로슈 아게 Novel biotin-specific monoclonal antibody and use thereof
CN109504650A (en) * 2017-09-15 2019-03-22 海门雨霖细胞科技有限责任公司 Small molecule induction human fibroblasts directly reprogram the method for liver cell
JP7307478B2 (en) * 2017-10-23 2023-07-12 国立大学法人九州大学 Method for producing hepatic stem cells or hepatic progenitor cells by direct reprogramming
JP7452799B2 (en) * 2018-12-26 2024-03-19 国立大学法人京都大学 Method for producing hepatocytes
US20220110979A1 (en) * 2019-01-11 2022-04-14 Figene, Llc Fibroblast regenerative cells
CN113423817B (en) * 2019-02-26 2023-05-26 北京大学 Compositions and methods for reprogramming non-hepatocytes to hepatocytes
CN114085874B (en) * 2022-01-10 2022-04-29 广东乾晖生物科技有限公司 Method for preparing immortalized liver cells with reversible liver functions and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
SI3611266T1 (en) 2005-08-23 2023-02-28 The Trustees Of The University Of Pennsylvania Rna containing modified nucleosides and methods of use thereof
WO2007127454A2 (en) 2006-04-28 2007-11-08 Cythera, Inc. Hepatocyte lineage cells
US8062632B2 (en) * 2008-06-23 2011-11-22 National Yang-Ming University Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof
SI3112467T1 (en) 2009-12-07 2018-06-29 The Trustees Of The University Of Pennsylvania Rna preparations comprising purified modified rna for reprogramming cells
WO2011102532A1 (en) * 2010-02-16 2011-08-25 国立大学法人九州大学 Induced hepatocytes
US8481317B2 (en) * 2010-04-13 2013-07-09 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
CN102465115B (en) * 2010-11-04 2014-03-05 中国科学院上海生命科学研究院 Hepatocyte preparation method
CN102286535B (en) * 2011-06-17 2013-06-05 中国人民解放军第二军医大学 Method for transdifferentiation of fibroblasts into hepatic stem cells

Also Published As

Publication number Publication date
HK1212384A1 (en) 2016-06-10
JP2015527084A (en) 2015-09-17
US20140087416A1 (en) 2014-03-27
EP2892999A1 (en) 2015-07-15
BR112015005011A2 (en) 2018-04-17
IL237433A0 (en) 2015-04-30
KR20150052228A (en) 2015-05-13
MX2015002917A (en) 2015-06-03
ZA201501435B (en) 2017-09-27
CN104781393A (en) 2015-07-15
US20150376570A1 (en) 2015-12-31
AU2013312440A1 (en) 2015-03-19
WO2014039768A1 (en) 2014-03-13
CA2883714A1 (en) 2014-03-13
RU2015107036A (en) 2016-10-27

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