HK1211572A1 - Piperidinium quaternary salts - Google Patents

Piperidinium quaternary salts Download PDF

Info

Publication number
HK1211572A1
HK1211572A1 HK15112219.3A HK15112219A HK1211572A1 HK 1211572 A1 HK1211572 A1 HK 1211572A1 HK 15112219 A HK15112219 A HK 15112219A HK 1211572 A1 HK1211572 A1 HK 1211572A1
Authority
HK
Hong Kong
Prior art keywords
piperidinium
quaternary salts
acetoxy
propoxy
diphenyl
Prior art date
Application number
HK15112219.3A
Other languages
English (en)
Chinese (zh)
Inventor
Kathleen E. Clarence-Smith
Thomas N. Chase
Original Assignee
Chase Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chase Pharmaceuticals Corporation filed Critical Chase Pharmaceuticals Corporation
Publication of HK1211572A1 publication Critical patent/HK1211572A1/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
HK15112219.3A 2012-08-09 2013-07-30 Piperidinium quaternary salts HK1211572A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261681415P 2012-08-09 2012-08-09
US61/681,415 2012-08-09
PCT/US2013/052626 WO2014025569A1 (en) 2012-08-09 2013-07-30 Piperidinium quaternary salts

Publications (1)

Publication Number Publication Date
HK1211572A1 true HK1211572A1 (en) 2016-05-27

Family

ID=50068488

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112219.3A HK1211572A1 (en) 2012-08-09 2013-07-30 Piperidinium quaternary salts

Country Status (14)

Country Link
US (1) US9896416B2 (https=)
EP (1) EP2882711B1 (https=)
JP (1) JP6345665B2 (https=)
KR (2) KR102240999B1 (https=)
CN (2) CN108658842A (https=)
AU (1) AU2013300009B2 (https=)
BR (1) BR112015002832B1 (https=)
CA (1) CA2881182C (https=)
EA (1) EA029678B9 (https=)
HK (1) HK1211572A1 (https=)
IL (1) IL236996A0 (https=)
IN (1) IN2015DN01018A (https=)
MX (1) MX356386B (https=)
WO (1) WO2014025569A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978201A1 (en) 2015-03-06 2016-09-15 Chase Pharmaceuticals Corporation Use of oxybutynin transdermal formulations to reduce side effects associated with muscarinic agonists
US20180360845A1 (en) * 2015-07-20 2018-12-20 Chase Pharmaceuticals Corporation Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders
CN114868435B (zh) 2019-08-22 2023-12-26 欧芬诺有限责任公司 针对多址接入的策略控制
CN117018194B (zh) * 2023-07-26 2026-04-17 同济大学 毒蕈碱型受体5型受体拮抗剂的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD106643A1 (https=) * 1973-07-12 1974-06-20
CN1285348A (zh) 1999-08-20 2001-02-28 广东康美药业股份有限公司 盐酸丙哌维林合成工艺
DE10129832A1 (de) * 2001-06-17 2003-07-10 Berolina Drug Dev Ab Svedala Deuterierte N- und alpha-substituierte Diphenylalkoxyessigsäureaminoalkylester sowie diese Verbindungen enthaltende Arzneimittel
CA2384922C (en) * 2002-05-03 2008-09-02 Purepharm Inc. Topical glycopyrrolate product for the reduction of sweating
KR100510788B1 (ko) 2003-07-22 2005-08-26 동방에프티엘 주식회사 프로필벤질릭산 에스터로부터 염산 프로피베린의 제조방법
KR100500760B1 (ko) 2003-07-22 2005-07-14 동방에프티엘 주식회사 염산 프로피베린의 제조방법
EP1713473B1 (en) * 2004-02-06 2013-03-13 MEDA Pharma GmbH & Co. KG The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and copd
CA2618933C (en) * 2005-08-12 2016-09-20 Dietmar Plenz Neuronal avalanche assay
CN1951938A (zh) * 2005-10-21 2007-04-25 刘丽娅 戊乙奎醚季铵盐及其衍生物
SE0600876L (sv) 2006-04-20 2007-10-21 Sandvik Intellectual Property Verktyg och skär för spånavskiljande bearbetning med primära och sekundära ingreppsmedel med rotationssymmetrisk form
CN101490003A (zh) 2006-04-24 2009-07-22 阿斯利康(瑞典)有限公司 具有毒蕈碱m3受体拮抗剂活性、用于治疗入慢性支气管阻塞、哮喘和膀胱过动的新型环状氨基醇的取代烷基酯类化合物
WO2007123465A1 (en) * 2006-04-24 2007-11-01 Astrazeneca Ab New alkyl esters of cyclic amino alcohols with muscarinic m3 receptor antagonist activity, useful for treating e.g. chronic bronchial obstruction, asthma and overactive bladder
EP2470504B1 (en) * 2010-03-15 2013-10-16 Ramesha Andagar Ramakrishna Synthesis of propiverine hydrochloride
KR101149821B1 (ko) 2010-04-05 2012-05-24 하나제약 주식회사 디페닐아세테이트 유도체의 새로운 제조방법
CN102218063B (zh) 2011-04-12 2013-03-13 贵州神奇制药有限公司 盐酸丙哌维林药物的制备方法和产品及其检测方法
EP4035668A1 (en) * 2012-09-05 2022-08-03 Chase Pharmaceuticals Corporation Anticholinergic neuroprotective composition and methods

Also Published As

Publication number Publication date
EA029678B1 (ru) 2018-04-30
MX2015001769A (es) 2015-05-08
KR20150040355A (ko) 2015-04-14
EP2882711A4 (en) 2016-02-10
EP2882711B1 (en) 2017-10-25
KR102240999B1 (ko) 2021-04-15
JP6345665B2 (ja) 2018-06-20
US20150203452A1 (en) 2015-07-23
CN108658842A (zh) 2018-10-16
EA201500209A1 (ru) 2015-05-29
EA029678B9 (ru) 2018-07-31
AU2013300009B2 (en) 2017-06-15
CA2881182C (en) 2021-01-26
US9896416B2 (en) 2018-02-20
WO2014025569A1 (en) 2014-02-13
EP2882711A1 (en) 2015-06-17
CA2881182A1 (en) 2014-02-13
BR112015002832A2 (https=) 2017-07-04
IL236996A0 (en) 2015-03-31
MX356386B (es) 2018-05-28
AU2013300009A1 (en) 2015-02-26
KR20200022522A (ko) 2020-03-03
BR112015002832B1 (pt) 2022-08-16
IN2015DN01018A (https=) 2015-06-26
JP2015524469A (ja) 2015-08-24
CN104603108A (zh) 2015-05-06

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