HK1210773A1 - Crystal form of dabigatran etexilate mesylate and preparation method and use thereof - Google Patents
Crystal form of dabigatran etexilate mesylate and preparation method and use thereofInfo
- Publication number
- HK1210773A1 HK1210773A1 HK15111433.5A HK15111433A HK1210773A1 HK 1210773 A1 HK1210773 A1 HK 1210773A1 HK 15111433 A HK15111433 A HK 15111433A HK 1210773 A1 HK1210773 A1 HK 1210773A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- crystal form
- dabigatran etexilate
- etexilate mesylate
- mesylate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410077142.8A CN104892574A (zh) | 2014-03-04 | 2014-03-04 | 达比加群酯甲磺酸盐的晶型及其制备方法和用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1210773A1 true HK1210773A1 (en) | 2016-05-06 |
Family
ID=54025588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15111433.5A HK1210773A1 (en) | 2014-03-04 | 2015-11-19 | Crystal form of dabigatran etexilate mesylate and preparation method and use thereof |
Country Status (5)
Country | Link |
---|---|
US (1) | US9718802B2 (xx) |
EP (1) | EP3115360A4 (xx) |
CN (2) | CN104892574A (xx) |
HK (1) | HK1210773A1 (xx) |
WO (1) | WO2015131829A1 (xx) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114716411B (zh) * | 2022-04-29 | 2024-03-15 | 天方药业有限公司 | 一种从生产母液中回收制备甲磺酸达比加群酯的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
DE102005020002A1 (de) | 2005-04-27 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
DE102005025728A1 (de) | 2005-06-04 | 2006-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester |
WO2008043759A1 (en) * | 2006-10-10 | 2008-04-17 | Boehringer Ingelheim International Gmbh | Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester |
CN102050815B (zh) | 2009-11-06 | 2014-04-02 | 北京美倍他药物研究有限公司 | 作为前药的达比加群的酯衍生物 |
HUP1000069A2 (en) | 2010-02-02 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | New salts for the preparation of pharmaceutical composition |
WO2012027543A1 (en) * | 2010-08-25 | 2012-03-01 | Teva Pharmaceuticals Usa, Inc. | Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof |
PL2603503T3 (pl) | 2010-09-27 | 2015-12-31 | Ratiopharm Gmbh | Sól bismesylanowa eteksylanu dabigatranu, postacie stałe i sposób ich otrzymywania |
WO2012077136A2 (en) * | 2010-12-06 | 2012-06-14 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
EP2522662A1 (en) * | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
CN102391250B (zh) * | 2011-08-29 | 2013-06-19 | 石药集团欧意药业有限公司 | 一种达比加群酯化合物、制备方法及其药物组合物 |
EP2631234A1 (en) | 2012-02-23 | 2013-08-28 | Esteve Química, S.A. | Solid forms of dabigatran etexilate mesylate and processes for their preparation |
WO2014009966A2 (en) * | 2012-07-12 | 2014-01-16 | Rao Davuluri Ramamohan | An improved process for the preparation of dabigatran etexilate mesylate and its intermediates thereof |
CN103288800B (zh) | 2013-06-03 | 2016-03-30 | 华仁药业股份有限公司 | 达比加群酯苯磺酸盐及其制备方法和应用 |
-
2014
- 2014-03-04 CN CN201410077142.8A patent/CN104892574A/zh active Pending
-
2015
- 2015-03-04 EP EP15759282.5A patent/EP3115360A4/en not_active Withdrawn
- 2015-03-04 US US15/123,378 patent/US9718802B2/en active Active
- 2015-03-04 CN CN201580013529.XA patent/CN106458975B/zh active Active
- 2015-03-04 WO PCT/CN2015/073650 patent/WO2015131829A1/zh active Application Filing
- 2015-11-19 HK HK15111433.5A patent/HK1210773A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20170073327A1 (en) | 2017-03-16 |
CN106458975A (zh) | 2017-02-22 |
CN106458975B (zh) | 2020-08-18 |
US9718802B2 (en) | 2017-08-01 |
EP3115360A4 (en) | 2017-10-18 |
EP3115360A1 (en) | 2017-01-11 |
WO2015131829A1 (zh) | 2015-09-11 |
CN104892574A (zh) | 2015-09-09 |
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