HK1210773A1 - Crystal form of dabigatran etexilate mesylate and preparation method and use thereof - Google Patents

Crystal form of dabigatran etexilate mesylate and preparation method and use thereof

Info

Publication number
HK1210773A1
HK1210773A1 HK15111433.5A HK15111433A HK1210773A1 HK 1210773 A1 HK1210773 A1 HK 1210773A1 HK 15111433 A HK15111433 A HK 15111433A HK 1210773 A1 HK1210773 A1 HK 1210773A1
Authority
HK
Hong Kong
Prior art keywords
preparation
crystal form
dabigatran etexilate
etexilate mesylate
mesylate
Prior art date
Application number
HK15111433.5A
Other languages
English (en)
Chinese (zh)
Inventor
張亮
劉川
許金溢
張昭昭
陳智
柴健
楊志清
羅海榮
張相洋
Original Assignee
Zhejiang Hisun Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Hisun Pharm Co Ltd filed Critical Zhejiang Hisun Pharm Co Ltd
Publication of HK1210773A1 publication Critical patent/HK1210773A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42Separation; Purification; Stabilisation; Use of additives
    • C07C303/44Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15111433.5A 2014-03-04 2015-11-19 Crystal form of dabigatran etexilate mesylate and preparation method and use thereof HK1210773A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410077142.8A CN104892574A (zh) 2014-03-04 2014-03-04 达比加群酯甲磺酸盐的晶型及其制备方法和用途

Publications (1)

Publication Number Publication Date
HK1210773A1 true HK1210773A1 (en) 2016-05-06

Family

ID=54025588

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111433.5A HK1210773A1 (en) 2014-03-04 2015-11-19 Crystal form of dabigatran etexilate mesylate and preparation method and use thereof

Country Status (5)

Country Link
US (1) US9718802B2 (xx)
EP (1) EP3115360A4 (xx)
CN (2) CN104892574A (xx)
HK (1) HK1210773A1 (xx)
WO (1) WO2015131829A1 (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114716411B (zh) * 2022-04-29 2024-03-15 天方药业有限公司 一种从生产母液中回收制备甲磺酸达比加群酯的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
DE102005020002A1 (de) 2005-04-27 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
DE102005025728A1 (de) 2005-06-04 2006-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester
WO2008043759A1 (en) * 2006-10-10 2008-04-17 Boehringer Ingelheim International Gmbh Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
CN102050815B (zh) 2009-11-06 2014-04-02 北京美倍他药物研究有限公司 作为前药的达比加群的酯衍生物
HUP1000069A2 (en) 2010-02-02 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag New salts for the preparation of pharmaceutical composition
WO2012027543A1 (en) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
PL2603503T3 (pl) 2010-09-27 2015-12-31 Ratiopharm Gmbh Sól bismesylanowa eteksylanu dabigatranu, postacie stałe i sposób ich otrzymywania
WO2012077136A2 (en) * 2010-12-06 2012-06-14 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and its salts
EP2522662A1 (en) * 2011-05-11 2012-11-14 Medichem, S.A. Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers
CN102391250B (zh) * 2011-08-29 2013-06-19 石药集团欧意药业有限公司 一种达比加群酯化合物、制备方法及其药物组合物
EP2631234A1 (en) 2012-02-23 2013-08-28 Esteve Química, S.A. Solid forms of dabigatran etexilate mesylate and processes for their preparation
WO2014009966A2 (en) * 2012-07-12 2014-01-16 Rao Davuluri Ramamohan An improved process for the preparation of dabigatran etexilate mesylate and its intermediates thereof
CN103288800B (zh) 2013-06-03 2016-03-30 华仁药业股份有限公司 达比加群酯苯磺酸盐及其制备方法和应用

Also Published As

Publication number Publication date
US20170073327A1 (en) 2017-03-16
CN106458975A (zh) 2017-02-22
CN106458975B (zh) 2020-08-18
US9718802B2 (en) 2017-08-01
EP3115360A4 (en) 2017-10-18
EP3115360A1 (en) 2017-01-11
WO2015131829A1 (zh) 2015-09-11
CN104892574A (zh) 2015-09-09

Similar Documents

Publication Publication Date Title
IL288243A (en) Heteroaryl-substituted pyridines and methods of use
IL250415B (en) Antibodies against pd-l and methods of using them
HK1253581A1 (zh) 經取代的吡啶及使用方法
HRP20190432T1 (hr) Spojevi pladienolid piridina i postupci uporabe
GB2546006B (en) Downhole apparatus and methods of use
EP2872500A4 (en) IMPROVED METHOD FOR THE PRODUCTION OF DABIGATRANETEXILATE MESYLATE AND INTERMEDIATE PRODUCTS THEREOF
IL234099A0 (en) Solid forms of dabigatran etexilate mesylate and processes for their preparation
GB2549053B (en) Wellbore isolation devices and methods of use
GB201421197D0 (en) Apparatus and method of use thereof
GB2549052B (en) Wellbore isolation devices and methods of use
HK1210773A1 (en) Crystal form of dabigatran etexilate mesylate and preparation method and use thereof
EP3165521A4 (en) Method of preparing dabigatran etexilate intermediate and intermediate compound
GB201522746D0 (en) Downhole apparatus and methods of use
GB2533616B (en) Infusion Device and Method of Making Same
GB2549054B (en) Wellbore isolation devices and methods of use
GB201709651D0 (en) Therapeutic parasite preparaton and methods of making and using
GB201512166D0 (en) Ceramic filter apparatus and method of use thereof
GB201416797D0 (en) Contianer and method of use thereof
GB201508694D0 (en) Construction apparatus and method of use thereof
GB201404133D0 (en) Garment and method of use thereof
GB201421437D0 (en) Sleeping aid apparatus and method of its operation
GB201416570D0 (en) Materials and methods for treatment of pulmonary arterial hypertenion
GB201412822D0 (en) Filter apparatus and method of use thereof