HK1210154A1 - Highly selective c-met inhibitors as anticancer agents c-met - Google Patents

Highly selective c-met inhibitors as anticancer agents c-met

Info

Publication number
HK1210154A1
HK1210154A1 HK15110897.6A HK15110897A HK1210154A1 HK 1210154 A1 HK1210154 A1 HK 1210154A1 HK 15110897 A HK15110897 A HK 15110897A HK 1210154 A1 HK1210154 A1 HK 1210154A1
Authority
HK
Hong Kong
Prior art keywords
met
anticancer agents
highly selective
inhibitors
met inhibitors
Prior art date
Application number
HK15110897.6A
Other languages
English (en)
Chinese (zh)
Inventor
Boyu Zhong
Chuan Shih
Hongbin Yuan
Feng Zhou
Original Assignee
Crown Bioscience Inc Taicang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crown Bioscience Inc Taicang filed Critical Crown Bioscience Inc Taicang
Publication of HK1210154A1 publication Critical patent/HK1210154A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15110897.6A 2012-09-03 2015-11-04 Highly selective c-met inhibitors as anticancer agents c-met HK1210154A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012103223591A CN103122000B (zh) 2012-09-03 2012-09-03 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
PCT/CN2013/080598 WO2014032498A1 (fr) 2012-09-03 2013-08-01 Inhibiteurs hautement sélectifs de c-met utilisés comme agents anticancéreux

Publications (1)

Publication Number Publication Date
HK1210154A1 true HK1210154A1 (en) 2016-04-15

Family

ID=48453178

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110897.6A HK1210154A1 (en) 2012-09-03 2015-11-04 Highly selective c-met inhibitors as anticancer agents c-met

Country Status (6)

Country Link
US (1) US9695175B2 (fr)
EP (1) EP2892904B1 (fr)
JP (1) JP6106899B2 (fr)
CN (1) CN103122000B (fr)
HK (1) HK1210154A1 (fr)
WO (1) WO2014032498A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105326793A (zh) * 2014-08-06 2016-02-17 中美冠科生物技术（太仓）有限公司 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途
CN106924260B (zh) * 2015-12-31 2018-05-25 北京浦润奥生物科技有限责任公司 化合物在制备用于治疗脑胶质瘤的药物中的用途
CN109206357A (zh) * 2017-07-04 2019-01-15 浙江九洲药业股份有限公司 一种格列齐特中间体的通式化合物及其制备方法和应用
CN112424222A (zh) * 2018-02-17 2021-02-26 冠科美博有限公司 使用中性粒细胞调节剂与免疫检查点调节剂的组合的癌症治疗
WO2020124060A1 (fr) * 2018-12-14 2020-06-18 Beta Pharma, Inc. Composés substitués par organophosphoré en tant qu'inhibiteurs de c-met et leurs utilisations thérapeutiques
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114599978A (zh) * 2019-06-06 2022-06-07 浙江冠科美博生物科技有限公司 使用c-met抑制剂治疗癌症患者的方法
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
US20230338294A1 (en) * 2020-04-26 2023-10-26 Apollomics Inc. Novel pharmaceutical formulation for c-met inhibitor
CN113105436B (zh) * 2021-04-20 2022-07-01 西格莱(苏州)生物医药有限公司 吡唑类化合物的制备方法及其中间体
CN116283997A (zh) * 2022-09-08 2023-06-23 药康众拓(江苏)医药科技有限公司 氘代hgfr抑制剂药物及用途
WO2024068947A1 (fr) 2022-09-30 2024-04-04 Syngenta Crop Protection Ag Dérivés de pyrazole microbiocides
WO2024068950A1 (fr) 2022-09-30 2024-04-04 Syngenta Crop Protection Ag Dérivés de pyrazole microbiocides
WO2024115512A1 (fr) 2022-11-30 2024-06-06 Syngenta Crop Protection Ag Dérivés de tétrahydroisoquinoline microbiocides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101412675B1 (ko) * 2005-12-21 2014-07-03 얀센 파마슈티카 엔.브이. 티로신 키나제 모듈레이터로서의 트리아졸로피리다진
PE20080403A1 (es) * 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
CN101553490A (zh) * 2006-10-23 2009-10-07 Sgx药品公司 用作蛋白激酶调节剂的二环三唑类化合物
KR101083177B1 (ko) * 2006-10-23 2011-11-11 에스지엑스 파마슈티컬스, 인코포레이티드 트리아졸로-피리다진 단백질 키나제 조정제
DK2084162T3 (da) * 2006-10-23 2012-10-01 Sgx Pharmaceuticals Inc Bicykliske triazoler som proteinkinasemodulatorer
PE20091468A1 (es) * 2008-02-28 2009-10-22 Novartis Ag DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA
AR085183A1 (es) * 2010-07-30 2013-09-18 Lilly Co Eli Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer

Also Published As

Publication number Publication date
EP2892904B1 (fr) 2018-10-17
US20150218171A1 (en) 2015-08-06
JP2015526486A (ja) 2015-09-10
WO2014032498A1 (fr) 2014-03-06
JP6106899B2 (ja) 2017-04-05
CN103122000A (zh) 2013-05-29
US9695175B2 (en) 2017-07-04
EP2892904A1 (fr) 2015-07-15
EP2892904A4 (fr) 2016-04-06
CN103122000B (zh) 2013-12-25

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