HK1208861A1 - Phenyl amino pyrimidine bicyclic compounds and uses thereof - Google Patents
Phenyl amino pyrimidine bicyclic compounds and uses thereofInfo
- Publication number
- HK1208861A1 HK1208861A1 HK15109468.7A HK15109468A HK1208861A1 HK 1208861 A1 HK1208861 A1 HK 1208861A1 HK 15109468 A HK15109468 A HK 15109468A HK 1208861 A1 HK1208861 A1 HK 1208861A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- phenyl amino
- bicyclic compounds
- amino pyrimidine
- pyrimidine bicyclic
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261666725P | 2012-06-29 | 2012-06-29 | |
US13/830,152 US8809359B2 (en) | 2012-06-29 | 2013-03-14 | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
AU2013201780A AU2013201780B2 (en) | 2012-06-29 | 2013-03-21 | Phenyl Amino Pyrimidine Bicyclic Compounds And Uses Thereof |
PCT/AU2013/000687 WO2014000032A1 (fr) | 2012-06-29 | 2013-06-26 | Composés phénylamino-pyrimidine bicycliques et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1208861A1 true HK1208861A1 (en) | 2016-03-18 |
Family
ID=49778746
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109468.7A HK1208861A1 (en) | 2012-06-29 | 2015-09-25 | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
HK15109881.6A HK1209120A1 (en) | 2012-06-29 | 2015-10-09 | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109881.6A HK1209120A1 (en) | 2012-06-29 | 2015-10-09 | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US8809359B2 (fr) |
EP (1) | EP2867238B1 (fr) |
JP (2) | JP5931288B2 (fr) |
CN (1) | CN104583216A (fr) |
AU (1) | AU2013201780B2 (fr) |
CA (1) | CA2877923C (fr) |
ES (1) | ES2644606T3 (fr) |
HK (2) | HK1208861A1 (fr) |
NZ (1) | NZ703343A (fr) |
PT (1) | PT2867238T (fr) |
WO (1) | WO2014000032A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2152701T3 (en) | 2007-03-12 | 2016-02-15 | Ym Biosciences Australia Pty | Phenylaminopyrimidinforbindelser and uses thereof |
US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
TW202134236A (zh) | 2014-06-12 | 2021-09-16 | 美商西爾拉癌症醫學公司 | N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺 |
EP3255129B1 (fr) * | 2016-06-06 | 2024-01-24 | The Lubrizol Corporation | Adduits thiol-carboxyliques comme additifs de lubrification |
CN108707119A (zh) * | 2018-06-25 | 2018-10-26 | 抚顺大恒化工有限公司 | 一种Momelotinib的制备方法 |
CN111100076A (zh) * | 2019-12-30 | 2020-05-05 | 武汉九州钰民医药科技有限公司 | Jak抑制剂莫美洛替尼的制备方法 |
EP3944859A1 (fr) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Procédé de traitement des toxicités immunitaires induites par des inhibiteurs des points de contrôle immunitaire |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3481932A (en) | 1967-09-01 | 1969-12-02 | Searle & Co | 2-anilino-5-methyl-6-phenylpyrimidines and congeners |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
MXPA03008888A (es) | 2001-03-29 | 2005-03-07 | Vertex Pharma | Inhibidores de n-terminal c-jun cinasas (jnk) y otras proteinas cinasas. |
US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
DE60227538D1 (de) | 2001-09-12 | 2008-08-21 | Virexx Medical Corp | Festphasenmittel zur vaskulären okklusion mit immo |
WO2004016597A2 (fr) | 2002-08-14 | 2004-02-26 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la proteine kinase et leurs utilisations |
JP2006512314A (ja) | 2002-11-01 | 2006-04-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | Jakインヒビターおよび他のプロテインキナーゼインヒビターとしての組成物の使用 |
AU2003295396B2 (en) | 2002-11-04 | 2009-02-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl-pyramidine derivatives as JAK inhibitors |
CA2507406A1 (fr) | 2002-11-05 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Composes utiles comme inhibiteurs de proteines jak et autres proteines kinase |
GB0317841D0 (en) | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
AU2004261484A1 (en) | 2003-07-30 | 2005-02-10 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
AR051387A1 (es) | 2004-10-13 | 2007-01-10 | Wyeth Corp | Analogos de anilino-pirimidina |
US7593820B2 (en) | 2005-05-12 | 2009-09-22 | Cytopia Research Pty Ltd | Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof |
JP2009525337A (ja) | 2006-01-30 | 2009-07-09 | エクセリクシス, インク. | Jak−2調節因子としての4−アリール−2−アミノ−ピリミジン類又は4−アリール−2−アミノアルキル−ピリミジン類と使用方法 |
WO2007101232A2 (fr) | 2006-02-28 | 2007-09-07 | Cytopia Research Pty, Ltd. | Inhibition de jak2 pour traiter l'hypertension artérielle pulmonaire |
FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
DK2152701T3 (en) * | 2007-03-12 | 2016-02-15 | Ym Biosciences Australia Pty | Phenylaminopyrimidinforbindelser and uses thereof |
PT2200436E (pt) | 2007-09-04 | 2015-04-29 | Scripps Research Inst | Pirimidinilaminas substituídas como inibidoras da proteína quinase |
WO2009029998A1 (fr) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Composés rétrométaboliques |
US8309718B2 (en) * | 2007-11-16 | 2012-11-13 | Incyte Corporation | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
CA2715658C (fr) * | 2008-02-15 | 2016-07-19 | Rigel Pharmaceuticals, Inc. | Composes de pyrimidine-2-amine et leur utilisation en tant qu'inhibiteurs des kinases jak |
BRPI0917575A2 (pt) | 2008-08-05 | 2019-09-24 | Targegen Inc | métodos de tratamento de talassemia |
CN102869359A (zh) * | 2010-03-17 | 2013-01-09 | 弗·哈夫曼-拉罗切有限公司 | 咪唑并吡啶和嘌呤化合物、组合物和使用方法 |
NZ611654A (en) | 2010-12-03 | 2015-08-28 | Ym Biosciences Australia Pty | Treatment of jak2-mediated conditions |
BR112013028420A2 (pt) | 2011-05-02 | 2017-01-24 | Ym Biosciences Australia Pty | tratamento de mieloma múltiplo |
US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
-
2013
- 2013-03-14 US US13/830,152 patent/US8809359B2/en active Active
- 2013-03-21 AU AU2013201780A patent/AU2013201780B2/en not_active Ceased
- 2013-06-26 JP JP2015518724A patent/JP5931288B2/ja not_active Expired - Fee Related
- 2013-06-26 WO PCT/AU2013/000687 patent/WO2014000032A1/fr active Application Filing
- 2013-06-26 ES ES13809739.9T patent/ES2644606T3/es active Active
- 2013-06-26 EP EP13809739.9A patent/EP2867238B1/fr active Active
- 2013-06-26 CN CN201380041191.XA patent/CN104583216A/zh active Pending
- 2013-06-26 CA CA2877923A patent/CA2877923C/fr not_active Expired - Fee Related
- 2013-06-26 PT PT138097399T patent/PT2867238T/pt unknown
- 2013-06-26 NZ NZ703343A patent/NZ703343A/en not_active IP Right Cessation
-
2015
- 2015-09-10 JP JP2015178970A patent/JP6153980B2/ja not_active Expired - Fee Related
- 2015-09-25 HK HK15109468.7A patent/HK1208861A1/xx unknown
- 2015-10-09 HK HK15109881.6A patent/HK1209120A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2867238A1 (fr) | 2015-05-06 |
AU2013201780B2 (en) | 2015-04-02 |
CN104583216A (zh) | 2015-04-29 |
US20140005161A1 (en) | 2014-01-02 |
JP6153980B2 (ja) | 2017-06-28 |
NZ703343A (en) | 2015-12-24 |
CA2877923C (fr) | 2017-07-25 |
HK1209120A1 (en) | 2016-03-24 |
CA2877923A1 (fr) | 2014-01-03 |
EP2867238B1 (fr) | 2017-08-09 |
WO2014000032A1 (fr) | 2014-01-03 |
JP5931288B2 (ja) | 2016-06-08 |
JP2015525738A (ja) | 2015-09-07 |
PT2867238T (pt) | 2017-10-30 |
AU2013201780A1 (en) | 2014-01-16 |
ES2644606T3 (es) | 2017-11-29 |
JP2016028076A (ja) | 2016-02-25 |
US8809359B2 (en) | 2014-08-19 |
EP2867238A4 (fr) | 2015-05-06 |
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