HK1207624A1 - 3-o-heteroaryl-ingenol 3-o-- - Google Patents
3-o-heteroaryl-ingenol 3-o--Info
- Publication number
- HK1207624A1 HK1207624A1 HK15108129.0A HK15108129A HK1207624A1 HK 1207624 A1 HK1207624 A1 HK 1207624A1 HK 15108129 A HK15108129 A HK 15108129A HK 1207624 A1 HK1207624 A1 HK 1207624A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ingenol
- heteroaryl
- Prior art date
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Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- Chemical & Material Sciences (AREA)
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- Gerontology & Geriatric Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261664398P | 2012-06-26 | 2012-06-26 | |
US201361763206P | 2013-02-11 | 2013-02-11 | |
PCT/EP2013/062995 WO2014001215A2 (en) | 2012-06-26 | 2013-06-21 | 3-o-heteroaryl-ingenol |
Publications (1)
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HK1207624A1 true HK1207624A1 (en) | 2016-02-05 |
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HK15108129.0A HK1207624A1 (en) | 2012-06-26 | 2015-08-21 | 3-o-heteroaryl-ingenol 3-o-- |
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US (1) | US9422309B2 (es) |
EP (1) | EP2864290B1 (es) |
JP (1) | JP6216781B2 (es) |
KR (1) | KR20150024928A (es) |
CN (1) | CN104411685B (es) |
AU (1) | AU2013283511B2 (es) |
BR (1) | BR112014032244A2 (es) |
CA (1) | CA2875461A1 (es) |
DK (1) | DK2864290T3 (es) |
ES (1) | ES2640612T3 (es) |
HK (1) | HK1207624A1 (es) |
IL (1) | IL235925A0 (es) |
IN (1) | IN2014DN11023A (es) |
MX (1) | MX2014015497A (es) |
MY (1) | MY169215A (es) |
NZ (1) | NZ702835A (es) |
PL (1) | PL2864290T3 (es) |
PT (1) | PT2864290T (es) |
RU (1) | RU2015102095A (es) |
SG (1) | SG11201408016XA (es) |
WO (1) | WO2014001215A2 (es) |
ZA (1) | ZA201409022B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20150119434A1 (en) * | 2013-10-25 | 2015-04-30 | Leo Laboratories Limited | Method for Topically Treating Actinic Keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate) |
WO2016191835A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-5,20-acetonida, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0] heptano-2-carbaldeído, método de preparação do composto 2,2-dimetil-4-etinil-5 -trifenilfosforanilideno-1,3-dioxano e composto intermediário |
WO2017089300A1 (en) * | 2015-11-27 | 2017-06-01 | Leo Laboratories Limited | 3-alkylamido-3-deoxy-ingenols |
US10583140B2 (en) | 2016-01-27 | 2020-03-10 | Glaxosmithkline Intellectual Property Development Limited | Ingenol analogs, pharmaceutical compositions and methods of use thereof |
WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
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DE2902506A1 (de) * | 1979-01-23 | 1980-07-24 | Deutsches Krebsforsch | Verwendung von nicht oder nur gering irritierenden und/oder promovierenden diterpenalkoholen und von derivaten davon als antineoplastische mittel |
AUPO864097A0 (en) | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
US8106092B2 (en) * | 2004-12-13 | 2012-01-31 | Leo Laboratories Limited | Treatment of solid cancers |
JP2009517345A (ja) * | 2005-11-25 | 2009-04-30 | ペプリン リサーチ プロプライエタリー リミティッド | 創傷治癒の方法 |
GB0525680D0 (en) | 2005-12-16 | 2006-01-25 | Peplin Ltd | Therapeutic compositions |
US9895334B2 (en) * | 2007-04-30 | 2018-02-20 | Leo Laboratories Limited | Treatment of virally induced lesions |
EP2146780A1 (en) | 2007-05-11 | 2010-01-27 | Sonneborn Inc. | Petrolatums having silicone-like properties |
CA2822312A1 (en) | 2010-12-22 | 2012-06-28 | Gunnar Grue-Sorensen | 3-acyl-ingenols ii |
BR112013015855A2 (pt) * | 2010-12-22 | 2018-06-05 | Leo Laboratories Ltd | composto, uso de um composto, métodos de prevenção, tratamento, melhora ou profilaxia de distúrbios fisiológicos ou doenças, e de tratamento ou melhora de indicações cosméticas, e, composição farmacêutica. |
US9388124B2 (en) | 2010-12-22 | 2016-07-12 | Leo Laboratories Limited | Ingenol-3-acylates I |
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2013
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- 2013-06-21 CA CA2875461A patent/CA2875461A1/en not_active Abandoned
- 2013-06-21 PT PT137416814T patent/PT2864290T/pt unknown
- 2013-06-21 NZ NZ702835A patent/NZ702835A/en not_active IP Right Cessation
- 2013-06-21 MX MX2014015497A patent/MX2014015497A/es unknown
- 2013-06-21 SG SG11201408016XA patent/SG11201408016XA/en unknown
- 2013-06-21 KR KR1020157002108A patent/KR20150024928A/ko not_active Application Discontinuation
- 2013-06-21 DK DK13741681.4T patent/DK2864290T3/en active
- 2013-06-21 WO PCT/EP2013/062995 patent/WO2014001215A2/en active Application Filing
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- 2013-06-21 ES ES13741681.4T patent/ES2640612T3/es active Active
- 2013-06-21 US US14/409,374 patent/US9422309B2/en not_active Expired - Fee Related
- 2013-06-21 AU AU2013283511A patent/AU2013283511B2/en not_active Ceased
- 2013-06-21 RU RU2015102095A patent/RU2015102095A/ru not_active Application Discontinuation
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- 2013-06-21 PL PL13741681T patent/PL2864290T3/pl unknown
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2014
- 2014-11-26 IL IL235925A patent/IL235925A0/en unknown
- 2014-12-09 ZA ZA2014/09022A patent/ZA201409022B/en unknown
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2015
- 2015-08-21 HK HK15108129.0A patent/HK1207624A1/xx not_active IP Right Cessation
Also Published As
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SG11201408016XA (en) | 2015-03-30 |
US9422309B2 (en) | 2016-08-23 |
DK2864290T3 (en) | 2017-10-02 |
CA2875461A1 (en) | 2014-01-03 |
AU2013283511A1 (en) | 2014-12-18 |
NZ702835A (en) | 2017-05-26 |
IL235925A0 (en) | 2015-02-01 |
PT2864290T (pt) | 2017-09-19 |
BR112014032244A2 (pt) | 2017-06-27 |
EP2864290A2 (en) | 2015-04-29 |
WO2014001215A2 (en) | 2014-01-03 |
EP2864290B1 (en) | 2017-06-14 |
JP2015521639A (ja) | 2015-07-30 |
KR20150024928A (ko) | 2015-03-09 |
US20150175622A1 (en) | 2015-06-25 |
IN2014DN11023A (es) | 2015-09-25 |
ES2640612T3 (es) | 2017-11-03 |
MY169215A (en) | 2019-03-18 |
PL2864290T3 (pl) | 2017-11-30 |
RU2015102095A (ru) | 2016-08-10 |
CN104411685A (zh) | 2015-03-11 |
MX2014015497A (es) | 2015-03-06 |
JP6216781B2 (ja) | 2017-10-18 |
AU2013283511B2 (en) | 2017-10-26 |
ZA201409022B (en) | 2016-03-30 |
CN104411685B (zh) | 2017-03-29 |
WO2014001215A3 (en) | 2014-02-27 |
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