HK1206726A1 - 咪唑並三嗪酮化合物 - Google Patents

咪唑並三嗪酮化合物

Info

Publication number
HK1206726A1
HK1206726A1 HK15107211.1A HK15107211A HK1206726A1 HK 1206726 A1 HK1206726 A1 HK 1206726A1 HK 15107211 A HK15107211 A HK 15107211A HK 1206726 A1 HK1206726 A1 HK 1206726A1
Authority
HK
Hong Kong
Prior art keywords
imidazotriazinone compounds
imidazotriazinone
compounds
Prior art date
Application number
HK15107211.1A
Other languages
English (en)
Inventor
Amy Ripka
Gideon Shapiro
Andrew J Mcriner
Matthew Gregory Bursavich
Original Assignee
Forum Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forum Pharmaceuticals Inc filed Critical Forum Pharmaceuticals Inc
Publication of HK1206726A1 publication Critical patent/HK1206726A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15107211.1A 2012-03-19 2015-07-28 咪唑並三嗪酮化合物 HK1206726A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612866P 2012-03-19 2012-03-19
PCT/US2013/031516 WO2013142269A1 (en) 2012-03-19 2013-03-14 Imidazotriazinone compounds

Publications (1)

Publication Number Publication Date
HK1206726A1 true HK1206726A1 (zh) 2016-01-15

Family

ID=49223231

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107211.1A HK1206726A1 (zh) 2012-03-19 2015-07-28 咪唑並三嗪酮化合物

Country Status (4)

Country Link
US (2) US9725453B2 (zh)
EP (1) EP2828262A4 (zh)
HK (1) HK1206726A1 (zh)
WO (1) WO2013142269A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
IN2015DN02829A (zh) 2011-10-10 2015-09-11 Lundbeck & Co As H
WO2013142269A1 (en) 2012-03-19 2013-09-26 Envivo Pharmaceuticals, Inc. Imidazotriazinone compounds
TR201909606T4 (tr) 2014-07-31 2019-07-22 Basf Se Pi̇razollari hazirlamak i̇çi̇n i̇şlem
CN105439962A (zh) * 2014-09-19 2016-03-30 上海皓元生物医药科技有限公司 一种可工业化生产2-氯甲基嘧啶盐酸盐的方法
KR20230145498A (ko) 2015-05-11 2023-10-17 바스프 에스이 4-아미노-피리다진의 제조 방법
BR112018000254A2 (pt) 2015-07-07 2018-09-04 H Lundbeck As inibidores de pde9 com cadeia principal de imidazotriazinona e cadeia principal de imidazopirazinona para o tratamento de doenças periféricas
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
WO2019141131A1 (zh) * 2018-01-16 2019-07-25 中国科学院上海药物研究所 溴结构域抑制剂化合物及其用途
HUE065709T2 (hu) 2018-05-25 2024-06-28 Cardurion Pharmaceuticals Inc 6-[(3S,4S)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropirán-4-il-7H-imidazo[1,5-a] pirazin-8-on vegyület monohidrát és kristályos formái
KR20200068996A (ko) * 2018-12-06 2020-06-16 한국화학연구원 Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도
CN110563655A (zh) * 2019-09-24 2019-12-13 上海毕得医药科技有限公司 一种5-（2-溴乙基）嘧啶的制备方法
EP4153601A1 (en) * 2020-05-22 2023-03-29 Vanderbilt University Competitive and noncompetitive inhibitors of the muscarinic acetylcholine receptor m5
CN112724079A (zh) * 2021-02-04 2021-04-30 康化（上海）新药研发有限公司 一种6-甲氧基吡啶甲酸甲酯的合成方法
CN113072556B (zh) * 2021-03-30 2022-02-01 牡丹江医学院 一种用于治疗胶质瘤的药物及其制备方法
EP4173674A1 (en) * 2021-10-26 2023-05-03 Perha Pharmaceuticals Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
CN100430396C (zh) 1997-11-12 2008-11-05 拜耳医药保健股份公司 用作磷酸二酯酶抑制剂的2-苯基取代的咪唑并三嗪酮
US7087605B2 (en) * 2001-06-01 2006-08-08 Bayer Aktiengesellschaft 5-Ethyl-imidazotriazinones
CA2465632A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
DE10229778A1 (de) 2002-07-03 2004-01-29 Bayer Ag Neue Verwendung von Imidazotriazinonen
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
US20060264624A1 (en) * 2005-05-20 2006-11-23 Alexander Heim-Riether Methods for synthesizing imidazotriazinones
EP1896476A2 (en) * 2005-06-28 2008-03-12 Orchid Research Laboratories Limited Novel pyrazolopyrimidinone derivatives
KR101222330B1 (ko) 2007-05-11 2013-01-15 화이자 인코포레이티드 아미노-헤테로시클릭 화합물
EP2297133B1 (en) * 2008-06-25 2017-09-13 Forum Pharmaceuticals Inc. 1, 2 disubstituted heterocyclic compounds
RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
WO2013110768A1 (en) * 2012-01-26 2013-08-01 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone
WO2013142269A1 (en) 2012-03-19 2013-09-26 Envivo Pharmaceuticals, Inc. Imidazotriazinone compounds

Also Published As

Publication number Publication date
US20170327502A1 (en) 2017-11-16
US20150191476A1 (en) 2015-07-09
WO2013142269A1 (en) 2013-09-26
EP2828262A1 (en) 2015-01-28
US9969742B2 (en) 2018-05-15
US9725453B2 (en) 2017-08-08
EP2828262A4 (en) 2015-09-23

Similar Documents

Publication Publication Date Title
IL268013A (en) Tetrahydropyrazolopyrimidine compounds
HK1245780B (zh) 咪唑並吡咯烷酮化合物
IL237341A0 (en) Compounds that promote neurogenesis
GB201209138D0 (en) Compounds
GB201214750D0 (en) Compounds
GB201215357D0 (en) Compounds
EP2887803A4 (en) PRO-NEUROGENIC COMPOUNDS
HK1206726A1 (zh) 咪唑並三嗪酮化合物
GB201204985D0 (en) Compounds
GB201204125D0 (en) Compounds
PT2836495T (pt) Compostos de tetra-hidropirrolotiazina
HK1211283A1 (zh) 化合物
GB201209096D0 (en) Compounds
HK1206356A1 (zh) -取代的氰基吡唑化合物
GB201219820D0 (en) Compounds
GB201217310D0 (en) Compounds
GB201223429D0 (en) Compounds
GB201220029D0 (en) Compounds
GB201219819D0 (en) Compounds
GB201218799D0 (en) Compounds
GB201218758D0 (en) Compounds
GB201218774D0 (en) Compounds
GB201218776D0 (en) Compounds
GB201218018D0 (en) Compounds
GB201217290D0 (en) Compounds