HK1206718A1 - Azaindolines - Google Patents

Azaindolines

Info

Publication number
HK1206718A1
HK1206718A1 HK15107147.0A HK15107147A HK1206718A1 HK 1206718 A1 HK1206718 A1 HK 1206718A1 HK 15107147 A HK15107147 A HK 15107147A HK 1206718 A1 HK1206718 A1 HK 1206718A1
Authority
HK
Hong Kong
Prior art keywords
azaindolines
Prior art date
Application number
HK15107147.0A
Other languages
English (en)
Chinese (zh)
Inventor
Joan Heather Hogg
Yan Lou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1206718A1 publication Critical patent/HK1206718A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
HK15107147.0A 2012-10-11 2015-07-27 Azaindolines HK1206718A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712330P 2012-10-11 2012-10-11
PCT/EP2013/070877 WO2014056867A1 (en) 2012-10-11 2013-10-08 Azaindolines

Publications (1)

Publication Number Publication Date
HK1206718A1 true HK1206718A1 (en) 2016-01-15

Family

ID=49326661

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107147.0A HK1206718A1 (en) 2012-10-11 2015-07-27 Azaindolines

Country Status (11)

Country Link
US (1) US9340573B2 (ko)
EP (1) EP2906560B1 (ko)
JP (1) JP6333267B2 (ko)
KR (1) KR20150064736A (ko)
CN (1) CN104640860B (ko)
BR (1) BR112015005627A2 (ko)
CA (1) CA2879870A1 (ko)
HK (1) HK1206718A1 (ko)
MX (1) MX2015004469A (ko)
RU (1) RU2015113961A (ko)
WO (1) WO2014056867A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590656A1 (ru) * 2012-10-11 2015-07-30 Ф. Хоффманн-Ля Рош Аг Азаиндолины
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2573644A1 (en) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
CN102171209A (zh) * 2008-08-02 2011-08-31 健泰科生物技术公司 Iap抑制剂
EP2493879B1 (en) * 2009-10-28 2014-05-14 Joyant Pharmaceuticals, Inc. Dimeric smac mimetics
USRE47009E1 (en) * 2011-02-01 2018-08-28 The Children's Hospital Of Philadelphia HDAC inhibitors and therapeutic methods using the same

Also Published As

Publication number Publication date
CN104640860A (zh) 2015-05-20
JP2015534569A (ja) 2015-12-03
BR112015005627A2 (pt) 2017-08-08
CA2879870A1 (en) 2014-04-17
US9340573B2 (en) 2016-05-17
KR20150064736A (ko) 2015-06-11
US20150252072A1 (en) 2015-09-10
EP2906560A1 (en) 2015-08-19
EP2906560B1 (en) 2017-02-22
MX2015004469A (es) 2015-07-14
WO2014056867A1 (en) 2014-04-17
RU2015113961A (ru) 2016-12-10
JP6333267B2 (ja) 2018-05-30
CN104640860B (zh) 2017-05-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20211010