HK1205506A1 - Protein kinase inhibitors - Google Patents

Protein kinase inhibitors

Info

Publication number
HK1205506A1
HK1205506A1 HK15106057.0A HK15106057A HK1205506A1 HK 1205506 A1 HK1205506 A1 HK 1205506A1 HK 15106057 A HK15106057 A HK 15106057A HK 1205506 A1 HK1205506 A1 HK 1205506A1
Authority
HK
Hong Kong
Prior art keywords
protein kinase
kinase inhibitors
inhibitors
protein
kinase
Prior art date
Application number
HK15106057.0A
Other languages
English (en)
Chinese (zh)
Inventor
Haihong Huang
Chunrong Yu
Dongfeng Zhang
Peng Li
Original Assignee
Astar Biotech Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astar Biotech Llc filed Critical Astar Biotech Llc
Publication of HK1205506A1 publication Critical patent/HK1205506A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
HK15106057.0A 2012-07-30 2015-06-25 Protein kinase inhibitors HK1205506A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/561,960 US8859553B2 (en) 2012-07-30 2012-07-30 Protein kinase inhibitors
PCT/CN2013/000897 WO2014019338A1 (en) 2012-07-30 2013-07-30 Protein kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1205506A1 true HK1205506A1 (en) 2015-12-18

Family

ID=49995471

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15106057.0A HK1205506A1 (en) 2012-07-30 2015-06-25 Protein kinase inhibitors
HK15106058.9A HK1205507A1 (en) 2012-07-30 2015-06-25 Protein kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15106058.9A HK1205507A1 (en) 2012-07-30 2015-06-25 Protein kinase inhibitors

Country Status (7)

Country Link
US (1) US8859553B2 (xx)
EP (1) EP2880038B1 (xx)
JP (2) JP2015523402A (xx)
CN (1) CN104470934B (xx)
ES (1) ES2673231T3 (xx)
HK (2) HK1205506A1 (xx)
WO (1) WO2014019338A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2477723C2 (ru) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
EP3186247B1 (en) * 2014-08-26 2021-03-03 Astar Biotech LLC Protein kinase inhibitors
CN104327083A (zh) * 2014-09-12 2015-02-04 辽宁大学 取代二氢茚酰胺类化合物及其药学上可接受的盐及制备方法和应用
CN106167491A (zh) * 2015-05-19 2016-11-30 重庆大学 一种有效抑制肺癌转移的化合物及其应用
CN107226809A (zh) * 2016-03-23 2017-10-03 浙江大德药业集团有限公司 酪氨酸激酶抑制剂
CN107353286A (zh) * 2016-05-10 2017-11-17 北京生命科学研究所 新型咪唑并[1,2-b]哒嗪酰胺类Bcr-Abl激酶抑制剂及其制备方法和应用
CN108456163A (zh) * 2017-02-20 2018-08-28 中国科学院上海药物研究所 含邻氨基杂芳环炔基的化合物及其制备方法和用途
EP3986559A1 (en) * 2019-06-24 2022-04-27 BenevolentAI Bio Limited New compounds and methods
BR112023019435A2 (pt) 2021-04-05 2023-10-24 Halia Therapeutics Inc Inibidores de nek7
AU2021440841A1 (en) * 2021-04-13 2023-10-19 Shenzhen Newdel Biotech Co., Ltd. Alkynylphenylbenzamide compound and use thereof
WO2022226182A1 (en) 2021-04-22 2022-10-27 Halia Therapeutics, Inc. Nek7 inhibitors
CN113666876B (zh) * 2021-07-05 2023-09-29 佛山市南海北沙制药有限公司 一种磺胺氯哒嗪的生产工艺

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH504505A (de) * 1966-08-15 1971-03-15 Ciba Geigy Ag Verwendung von neuen Tolanderivaten als optische Aufhellmittel ausserhalb der Textilindustrie
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US5455260A (en) * 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
JP3990061B2 (ja) * 1998-01-05 2007-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 プリン誘導体および糖尿病の予防・治療剤としてのアデノシンａ２受容体拮抗剤
JP2006520794A (ja) * 2003-03-21 2006-09-14 スミスクライン ビーチャム コーポレーション 化合物
TW200530368A (en) * 2003-10-01 2005-09-16 Ube Industries Heterocyclic ring substituded phenylacetylene compound, method for producing the same and organic electroluminescence element using the same
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
AU2006324144A1 (en) * 2005-01-28 2007-08-02 Merck Sharp & Dohme Corp. Inhibitors of checkpoint kinases
CA2594657A1 (en) * 2005-02-08 2006-08-17 Merck & Co., Inc. Inhibitors of checkpoint kinases
US7745641B2 (en) * 2005-04-19 2010-06-29 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
GB0520164D0 (en) * 2005-10-04 2005-11-09 Novartis Ag Organic compounds
EP1960382A1 (en) * 2005-11-03 2008-08-27 ChemBridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
KR101436303B1 (ko) * 2005-12-23 2014-09-02 어리어드 파마슈티칼스, 인코포레이티드 비시클릭 헤테로아릴 화합물
GB0602178D0 (en) * 2006-02-03 2006-03-15 Merck Sharp & Dohme Therapeutic treatment
EP2108642A1 (en) * 2006-10-17 2009-10-14 Kyowa Hakko Kirin Co., Ltd. Jak inhibitor
CN101743237A (zh) * 2007-07-16 2010-06-16 先正达参股股份有限公司 稠合的邻氨基苯甲酰胺杀虫剂
EP2234486A4 (en) * 2007-12-19 2011-09-14 Scripps Research Inst BENZIMIDAZOLE AND ANALOGUE AS RHO-KINASEHEMMER
CA2784807C (en) * 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
JP2013526539A (ja) * 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用なピラジン
CN101885722B (zh) * 2010-07-01 2013-07-24 中国科学院广州生物医药与健康研究院 杂环炔苯类化合物及其药用组合物和应用
CN103370324B (zh) * 2010-12-27 2016-05-18 孙树萍 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途
RU2477723C2 (ru) * 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
CN102584830A (zh) * 2011-12-30 2012-07-18 北京赛林泰医药技术有限公司 二氢化茚酰胺化合物、其药物组合物及其用途
EP2841062A4 (en) * 2012-04-25 2015-11-25 Ariad Pharma Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY RAF KINASE
CN102775411A (zh) * 2012-08-17 2012-11-14 浙江大德药业集团有限公司 作为蛋白激酶抑制剂的芳乙炔基苯甲酰胺类化合物

Also Published As

Publication number Publication date
HK1205507A1 (en) 2015-12-18
US8859553B2 (en) 2014-10-14
JP2017039765A (ja) 2017-02-23
CN104470934B (zh) 2017-08-04
EP2880038A4 (en) 2016-03-09
ES2673231T3 (es) 2018-06-20
EP2880038B1 (en) 2018-05-16
JP6308504B2 (ja) 2018-04-11
US20140031354A1 (en) 2014-01-30
WO2014019338A1 (en) 2014-02-06
JP2015523402A (ja) 2015-08-13
CN104470934A (zh) 2015-03-25
EP2880038A1 (en) 2015-06-10

Similar Documents

Publication Publication Date Title
HK1215577A1 (zh) 蛋白激酶抑制劑
HK1217198A1 (zh) 蛋白激酶抑制劑
HK1200451A1 (zh) 蛋白激酶抑制劑
HK1210775A1 (en) Imidazotriazinecarbonitriles useful as kinase inhibitors
HK1208442A1 (en) Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk
EP2694517A4 (en) PROTEIN KINASE INHIBITORS
HK1200828A1 (en) Kinase inhibitors
HUE048834T2 (hu) Kináz inhibitorok
ZA201306855B (en) Protein kinase inhibitors
HK1209726A1 (en) Protein kinase inhibitors
HK1205506A1 (en) Protein kinase inhibitors
HK1218119A1 (zh) 蛋白激酶抑制劑
EP2833889A4 (en) PROTEIN KINASE C HEMMER AND USES THEREOF
IL229028A0 (en) Kinase inhibitors
HK1208460A1 (en) Protein kinase inhibitors
HK1199873A1 (en) Kinase inhibitors
SG11201500973WA (en) Amino-quinolines as kinase inhibitors
IL230504A0 (en) Selective protein kinase inhibitors
EP2879679A4 (en) ANTIBACTERIAL PROTEIN KINASE INHIBITORS
HK1210036A1 (en) Aminoisoquinoline derivatives as protein kinase inhibitors