HK1205453A1 - Methods of diagnosing and treating motor neuron diseases - Google Patents

Methods of diagnosing and treating motor neuron diseases

Info

Publication number
HK1205453A1
HK1205453A1 HK15105895.8A HK15105895A HK1205453A1 HK 1205453 A1 HK1205453 A1 HK 1205453A1 HK 15105895 A HK15105895 A HK 15105895A HK 1205453 A1 HK1205453 A1 HK 1205453A1
Authority
HK
Hong Kong
Prior art keywords
diagnosing
methods
motor neuron
neuron diseases
treating motor
Prior art date
Application number
HK15105895.8A
Other languages
English (en)
Chinese (zh)
Inventor
Eran Hornstein
Anna M Emde
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of HK1205453A1 publication Critical patent/HK1205453A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15105895.8A 2012-07-31 2015-06-19 Methods of diagnosing and treating motor neuron diseases HK1205453A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261677494P 2012-07-31 2012-07-31
PCT/IL2013/050655 WO2014020608A1 (en) 2012-07-31 2013-07-31 Methods of diagnosing and treating motor neuron diseases

Publications (1)

Publication Number Publication Date
HK1205453A1 true HK1205453A1 (en) 2015-12-18

Family

ID=49085064

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105895.8A HK1205453A1 (en) 2012-07-31 2015-06-19 Methods of diagnosing and treating motor neuron diseases

Country Status (6)

Country Link
US (1) US10159670B2 (de)
EP (1) EP2879678B1 (de)
JP (1) JP6340366B2 (de)
CN (1) CN104684558A (de)
HK (1) HK1205453A1 (de)
WO (1) WO2014020608A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3613852A3 (de) 2011-07-22 2020-04-22 President and Fellows of Harvard College Beurteilung und verbesserung einer nukleasespaltungsspezifität
JP6340366B2 (ja) 2012-07-31 2018-06-06 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 運動ニューロン疾患を診断および処置する方法
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
CN106459995B (zh) 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
US20150166984A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting alpha-antitrypsin point mutations
CN111500569A (zh) * 2014-03-05 2020-08-07 国立大学法人神户大学 特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
WO2016030899A1 (en) * 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
WO2016138287A1 (en) 2015-02-25 2016-09-01 Washington University METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
EP4218771A1 (de) 2015-03-27 2023-08-02 Yeda Research and Development Co. Ltd Verfahren zur behandlung von motoneuronenerkrankungen
JP6666002B2 (ja) * 2015-10-07 2020-03-13 国立大学法人京都大学 Ｔｄｐ−４３プロテノパシーの予防又は治療用組成物
IL258821B (en) 2015-10-23 2022-07-01 Harvard College Nucleobase editors and their uses
CN105663129B (zh) * 2015-12-29 2020-05-15 山东大学 用于治疗肌萎缩侧索硬化和额颞叶痴呆的化合物与应用
SG11201900907YA (en) 2016-08-03 2019-02-27 Harvard College Adenosine nucleobase editors and uses thereof
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
CN106620721B (zh) * 2016-09-30 2020-05-26 武汉大风生物科技有限公司 单核细胞趋化蛋白-1诱导蛋白1（Mcpip1）在肝缺血再灌注损伤中的应用
GB2573062A (en) 2016-10-14 2019-10-23 Harvard College AAV delivery of nucleobase editors
CN106377761A (zh) * 2016-10-27 2017-02-08 武汉大学 单核细胞趋化蛋白‑1诱导蛋白1在治疗脂肪肝和ⅱ型糖尿病中的功能和应用
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (de) 2017-03-09 2020-01-15 President and Fellows of Harvard College Unterdrückung von schmerzen durch geneditierung
WO2018165629A1 (en) 2017-03-10 2018-09-13 President And Fellows Of Harvard College Cytosine to guanine base editor
CA3057192A1 (en) 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
US10980780B2 (en) 2017-06-20 2021-04-20 Neurosense Therapeutics Ltd. Methods and compositions of anti-inflammatory drug and dicer activator for treatment of neuronal diseases
EP3641820B1 (de) * 2017-06-20 2022-12-28 Neurosense Therapeutics Ltd. Zusammensetzungen mit einem entzündungshemmer und einem dicer-aktivator zur verwendung bei der behandlung von nervenerkrankungen
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
US11795443B2 (en) 2017-10-16 2023-10-24 The Broad Institute, Inc. Uses of adenosine base editors
US20210269780A1 (en) * 2018-07-13 2021-09-02 The Trustees Of Princeton University System and method for modulating stress granule assembly
JP2022511317A (ja) * 2018-10-15 2022-01-31 マックスプランク－ゲセルシャフト・ツール・フェーデルング・デル・ヴィッセンシャフテン・エー・ファウ 疾患の治療のための化合物およびこれをスクリーニングする方法
EP3870699A4 (de) * 2018-10-26 2022-08-03 The Jackson Laboratory Behandlungen für morbus charcot-marie-tooth
WO2020191153A2 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
EP3969619A1 (de) 2019-05-13 2022-03-23 Yeda Research and Development Co. Ltd Zellfreie mirna-biomarker zur prognose und diagnose neurodegenerativer erkrankungen
US11851462B2 (en) * 2019-07-22 2023-12-26 University Of South Carolina Targeting G3BP aggregation to prevent neurodegeneration
WO2021178448A1 (en) * 2020-03-02 2021-09-10 Motor Life Sciences, Llc Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity
EP4114938A1 (de) * 2020-03-04 2023-01-11 The Trustees of Indiana University Verfahren zum erneuten greifen eines fötalen wundheilungswegs für hautreparatur bei erwachsenen
KR20230019843A (ko) 2020-05-08 2023-02-09 더 브로드 인스티튜트, 인코퍼레이티드 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물
CN112043721B (zh) * 2020-09-04 2022-01-28 南通大学 miR-132-5p在制备神经再生药物或材料中的应用
KR20220035693A (ko) * 2020-09-14 2022-03-22 주식회사 제너로스 표적화된 유전자 전달을 위한 아데노-부속 바이러스 벡터

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US6756369B2 (en) 1997-05-06 2004-06-29 Vanderbilt University Diagnosis and management of infection caused by Chlamydia
FR2801217B1 (fr) * 1999-11-24 2002-12-06 Aventis Pharma Sa Association de riluzole et de gabapentine et son utilisation comme medicament
KR20050115231A (ko) 2003-02-10 2005-12-07 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 포유동물 세포의 조절
CN1475215A (zh) * 2003-05-16 2004-02-18 海口康力元制药有限公司 注射用依诺沙星及其制作方法
EP2281888B1 (de) 2004-11-12 2015-01-07 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNA und miRNA-inhibitorischen Molekülen verbunden sind
US20090306035A1 (en) 2005-08-26 2009-12-10 Emory University Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
WO2008073961A2 (en) 2006-12-12 2008-06-19 Emory University Compounds and methods for modulating the silencing of a polynucleotide of interest
CN101390854A (zh) * 2007-09-21 2009-03-25 北京德众万全药物技术开发有限公司 一种含有利鲁唑的药用组合物
CA2718520C (en) 2008-03-17 2020-01-07 The Board Of Regents Of The University Of Texas System Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
US9976302B2 (en) 2008-07-14 2018-05-22 François Delaney Self-supporting pier for a retractable roof system for a large building structure
EP2633854B1 (de) * 2008-12-05 2015-09-16 Yeda Research And Development Co. Ltd. miRNA-9 or miRNA-9* zur Verwendung in der Behandlung von ALS
US9867837B2 (en) * 2011-03-01 2018-01-16 Pharnext Compositions for treating neurological disorders
CA2836791A1 (en) 2011-05-20 2012-11-29 Benjamin Wolozin Identification of compounds that disperse tdp-43 inclusions
US20140348857A1 (en) 2011-10-27 2014-11-27 Massachusetts Institute Of Technology Methods of diagnosis and treatment of endoplasmic reticulum (er) stress-related conditions
JP6340366B2 (ja) 2012-07-31 2018-06-06 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 運動ニューロン疾患を診断および処置する方法

Also Published As

Publication number Publication date
US10159670B2 (en) 2018-12-25
CN104684558A (zh) 2015-06-03
JP6340366B2 (ja) 2018-06-06
EP2879678B1 (de) 2023-03-01
WO2014020608A1 (en) 2014-02-06
EP2879678A1 (de) 2015-06-10
US20150164891A1 (en) 2015-06-18
JP2015523410A (ja) 2015-08-13

Similar Documents

Publication Publication Date Title
HK1205453A1 (en) Methods of diagnosing and treating motor neuron diseases
IL260714B (en) Methods for the treatment and diagnosis of blinding eye diseases
EP2890815A4 (de) Verfahren zur diagnose und behandlung von krebs
EP2874647A4 (de) Verfahren zur diagnose und behandlung
HK1211474A1 (en) Treatment of immune-related and inflammatory diseases
IL239368A0 (en) Sparing–ppar thiazolidinediones and combinations for the treatment of neurodegenerative diseases of the nervous system
EP2863949A4 (de) Verfahren zur behandlung oder verhinderung von parodontitis und mit parodontitis assoziierten erkrankungen
EP3084000A4 (de) Verfahren zur diagnose und behandlung
IL265717A (en) Lingo-2 antagonists for the treatment of conditions involving motor neurons
IL284969A (en) Diagnosis and treatment of autoimmune diseases
HK1215173A1 (zh) 治療金黃色葡萄球菌相關疾病的方法
EP2906295A4 (de) Verfahren zur behandlung von augenkrankheiten
HK1216504A1 (zh) 疾病的治療方法
EP2934543A4 (de) Stimulierung und verstärkung der geweberegeneration
EP2854784A4 (de) Verfahren zur behandlung von hautentzündungserkrankungen
EP2928460A4 (de) Verfahren zur vorbeugung und behandlung entzündlicher hauterkrankungen
IL236505A0 (en) Methods for diagnosis and treatment of motor neuron diseases
AU2012903104A0 (en) Method of diagnosis and treatment
EP2911662A4 (de) Verfahren zur behandlung von krankheiten
AU2013904912A0 (en) Method of Diagnosis and Treatment
GB201208505D0 (en) Treatment of skin condition
GB201216740D0 (en) Methods of treatment
GB201206324D0 (en) Methods of treatment
GB201206325D0 (en) Methods of treatment
GB201206326D0 (en) Methods of treatment