HK1204610A1 - 作為治療增殖性病症的 調節劑的咪唑並 吡啶衍生物 - Google Patents

作為治療增殖性病症的 調節劑的咪唑並 吡啶衍生物

Info

Publication number
HK1204610A1
HK1204610A1 HK15105101.8A HK15105101A HK1204610A1 HK 1204610 A1 HK1204610 A1 HK 1204610A1 HK 15105101 A HK15105101 A HK 15105101A HK 1204610 A1 HK1204610 A1 HK 1204610A1
Authority
HK
Hong Kong
Prior art keywords
jak
alk
imidazo
modulators
treatment
Prior art date
Application number
HK15105101.8A
Other languages
English (en)
Inventor
Henry J Breslin
Matthew A Curry
Diane E Gingrich
Keith S Learn
Gregory R Ott
Jason C Wagner
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of HK1204610A1 publication Critical patent/HK1204610A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15105101.8A 2012-01-30 2015-05-28 作為治療增殖性病症的 調節劑的咪唑並 吡啶衍生物 HK1204610A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261592074P 2012-01-30 2012-01-30
PCT/US2013/023778 WO2013116291A1 (en) 2012-01-30 2013-01-30 Imidazo [4, 5 - b] pyridine derivatives as alk and jak modulators for the treatment of proliferative disorders

Publications (1)

Publication Number Publication Date
HK1204610A1 true HK1204610A1 (zh) 2015-11-27

Family

ID=47684060

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105101.8A HK1204610A1 (zh) 2012-01-30 2015-05-28 作為治療增殖性病症的 調節劑的咪唑並 吡啶衍生物

Country Status (5)

Country Link
US (1) US9238656B2 (zh)
EP (1) EP2809671B1 (zh)
ES (1) ES2567552T3 (zh)
HK (1) HK1204610A1 (zh)
WO (1) WO2013116291A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017009600A (es) * 2015-02-02 2017-11-22 Kancera Ab Derivados de 2-fenil-3h-imidazo[4,5-b]piridina utiles como inhibidores de actividad de receptor huerfano similar a tirosina cinasa (ror1) de tirosina cinasa de mamifero.
US11660303B2 (en) 2016-07-11 2023-05-30 Kancera Ab 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity
EP3481824B1 (en) * 2016-07-11 2021-10-20 Kancera AB 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ror1 activity
CN108570048B (zh) * 2017-03-10 2021-06-08 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
GB201717260D0 (en) * 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders
EP3907225A4 (en) * 2019-02-01 2022-09-14 Hanmi Pharm. Co., Ltd. COMPOUNDS DERIVED FROM IMIDAZOPYRIDINE AND THEIR USE
US20220098205A1 (en) * 2019-02-01 2022-03-31 Hanmi Pharm. Co., Ltd. Imidazopyridine derivative compounds and use of same
EP3976612A4 (en) * 2019-05-28 2023-04-26 Mankind Pharma Ltd NEW COMPOUNDS FOR INHIBITION OF JANUS KINASE 1

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732217B1 (fr) 1995-03-29 1997-06-06 Hesnard Xavier Forme d'administration solide a usage oral
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
SE0301373D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
DE602006014540D1 (en) * 2005-05-16 2010-07-08 Irm Llc Pyrrolopyridinderivate als proteinkinaseinhibitoren
US7541367B2 (en) * 2005-05-31 2009-06-02 Janssen Pharmaceutica, N.V. 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
CA2615291A1 (en) * 2005-07-14 2007-01-18 Astellas Pharma Inc. Heterocyclic janus kinase 3 inhibitors
EP2251341A1 (en) * 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
EP1963320A1 (en) * 2005-12-07 2008-09-03 OSI Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
US8088761B2 (en) * 2005-12-22 2012-01-03 Cancer Research Technology Limited Enzyme inhibitors
US20070208053A1 (en) * 2006-01-19 2007-09-06 Arnold Lee D Fused heterobicyclic kinase inhibitors
WO2009001021A1 (en) * 2007-06-26 2008-12-31 Chroma Therapeutics Ltd. Imidazopyridine derivatives useful as enzyme inhibitors for the treatment of cell proliferative and autoimmune diseases
ES2893580T3 (es) * 2007-11-28 2022-02-09 Dana Farber Cancer Inst Inc Inhibidores de miristato de moléculas pequeñas de Bcr-abl y métodos de uso
EA020302B1 (ru) * 2009-08-07 2014-10-30 Мерк Патент Гмбх Новые азагетероциклические соединения
WO2012097478A1 (en) * 2011-01-21 2012-07-26 Abbott Laboratories Bicyclic carboxamide inhibitors of kinases
US9527850B2 (en) * 2011-09-26 2016-12-27 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist

Also Published As

Publication number Publication date
EP2809671A1 (en) 2014-12-10
US9238656B2 (en) 2016-01-19
US20140350011A1 (en) 2014-11-27
EP2809671B1 (en) 2016-01-13
ES2567552T3 (es) 2016-04-25
WO2013116291A1 (en) 2013-08-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200127