HK1203302A1 - Humanized il-7 rodents il-7 - Google Patents

Humanized il-7 rodents il-7

Info

Publication number
HK1203302A1
HK1203302A1 HK15103801.6A HK15103801A HK1203302A1 HK 1203302 A1 HK1203302 A1 HK 1203302A1 HK 15103801 A HK15103801 A HK 15103801A HK 1203302 A1 HK1203302 A1 HK 1203302A1
Authority
HK
Hong Kong
Prior art keywords
rodents
humanized
Prior art date
Application number
HK15103801.6A
Other languages
English (en)
Chinese (zh)
Inventor
Andrew Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1203302A1 publication Critical patent/HK1203302A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
HK15103801.6A 2012-06-18 2015-04-20 Humanized il-7 rodents il-7 HK1203302A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents

Publications (1)

Publication Number Publication Date
HK1203302A1 true HK1203302A1 (en) 2015-10-30

Family

ID=49757275

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15103801.6A HK1203302A1 (en) 2012-06-18 2015-04-20 Humanized il-7 rodents il-7
HK15104315.3A HK1203761A1 (en) 2012-06-18 2015-05-06 Humanized il-7 rodents il-7

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15104315.3A HK1203761A1 (en) 2012-06-18 2015-05-06 Humanized il-7 rodents il-7

Country Status (26)

Country Link
US (7) US8962913B2 (fi)
EP (2) EP2859793B1 (fi)
JP (1) JP6174134B2 (fi)
KR (1) KR20150027752A (fi)
CN (2) CN105779467A (fi)
AU (1) AU2013277457B2 (fi)
BR (1) BR112014029892A2 (fi)
CA (1) CA2873134A1 (fi)
CY (1) CY1119071T1 (fi)
DK (1) DK2859793T3 (fi)
ES (1) ES2626965T3 (fi)
HK (2) HK1203302A1 (fi)
HR (1) HRP20170974T1 (fi)
HU (1) HUE034592T2 (fi)
IL (3) IL235773B (fi)
IN (1) IN2014DN10189A (fi)
LT (1) LT2859793T (fi)
MX (1) MX363540B (fi)
NZ (1) NZ702943A (fi)
PL (1) PL2859793T3 (fi)
PT (1) PT2859793T (fi)
RS (1) RS56039B1 (fi)
RU (1) RU2654565C2 (fi)
SG (3) SG10201609569PA (fi)
SI (1) SI2859793T1 (fi)
WO (1) WO2013192030A1 (fi)

Families Citing this family (30)

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PT2564695E (pt) 2009-07-08 2015-06-03 Kymab Ltd Modelos animais e moléculas terapêuticas
JP2014533930A (ja) 2011-09-19 2014-12-18 カイマブ・リミテッド 免疫グロブリン遺伝子多様性の操作およびマルチ抗体治療薬
US9271271B2 (en) * 2012-03-05 2016-02-23 Samsung Electronics Co., Ltd HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
ES2959333T3 (es) 2013-09-23 2024-02-23 Regeneron Pharma Animales no humanos que tienen un gen humanizado de la proteína reguladora de señales
CA2925723A1 (en) 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
DK3138397T3 (en) 2013-10-15 2019-04-15 Regeneron Pharma Humanized IL-15 animals
MX2016014504A (es) * 2014-05-05 2017-05-23 Regeneron Pharma Animales c5 y c3 humanizados.
NO2785538T3 (fi) * 2014-05-07 2018-08-04
KR102617691B1 (ko) 2014-12-05 2023-12-27 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
DK3282835T3 (da) * 2015-04-13 2023-06-26 Regeneron Pharma Humaniserede SIRP?-IL-15-knockin-mus og fremgangsmåder til anvendelse deraf
CN108779159B (zh) 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
RU2749715C2 (ru) 2016-02-29 2021-06-16 Регенерон Фармасьютикалз, Инк. Грызуны, характеризующиеся гуманизированным геном tmprss
AU2018338790B2 (en) 2017-09-29 2022-09-15 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized TTR locus and methods of use
SG11202011284RA (en) 2018-07-16 2020-12-30 Regeneron Pharma Non-human animal models of ditra disease and uses thereof
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
CN114206108B (zh) 2019-04-04 2023-09-29 瑞泽恩制药公司 包括人源化凝血因子12基因座的非人动物
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
SG11202111256XA (en) 2019-06-07 2021-11-29 Regeneron Pharma Non-human animals comprising a humanized albumin locus
WO2021027737A1 (en) * 2019-08-09 2021-02-18 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
AU2021212668A1 (en) * 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
KR102316506B1 (ko) 2020-02-26 2021-10-22 차의과학대학교 산학협력단 동물 면역계의 인간화 활성을 촉진하는 방법
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
KR20230124973A (ko) * 2020-12-21 2023-08-28 리제너론 파마슈티칼스 인코포레이티드 인간화 tslp 유전자, 인간화 tslp 수용체 유전자, 및/또는인간화 il7ra 유전자를 갖는 비인간 동물
CN114835798B (zh) * 2021-05-28 2024-02-23 百奥赛图(北京)医药科技股份有限公司 Cd36基因人源化非人动物的构建方法及应用
WO2024054904A1 (en) * 2022-09-08 2024-03-14 The Jackson Laboratory Humanized immunodeficient mouse models

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ZA887773B (en) * 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
CA2382383A1 (en) 1999-08-31 2001-03-08 Genencor International, Inc. Transgenic mammal capable of facilitating production of donor-specific functional immunity
US7759541B2 (en) 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
GB2434578A (en) 2006-01-26 2007-08-01 Univ Basel Transgenic animals
CN101302517B (zh) * 2008-02-03 2010-11-03 中国科学院广州生物医药与健康研究院 人白细胞介素7在真核宿主中表达的方法
DK3417701T3 (da) * 2009-10-06 2022-03-14 Regeneron Pharma Genmodificerede mus og indpodning
EP4233537A3 (en) 2011-02-15 2023-09-13 Regeneron Pharmaceuticals, Inc. Humanized m-csf mice and uses thereof
CN108866101A (zh) 2011-10-28 2018-11-23 瑞泽恩制药公司 人源化il-6和il-6受体
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents

Also Published As

Publication number Publication date
US20160052986A1 (en) 2016-02-25
RS56039B1 (sr) 2017-09-29
HRP20170974T1 (hr) 2017-09-22
KR20150027752A (ko) 2015-03-12
US10314298B2 (en) 2019-06-11
NZ702943A (en) 2017-07-28
US8962913B2 (en) 2015-02-24
CA2873134A1 (en) 2013-12-27
AU2013277457B2 (en) 2018-03-15
CY1119071T1 (el) 2018-01-10
RU2014148107A (ru) 2016-08-10
US20190343093A1 (en) 2019-11-14
SG10201609576YA (en) 2016-12-29
WO2013192030A1 (en) 2013-12-27
US20130340104A1 (en) 2013-12-19
IL235773A0 (en) 2015-01-29
EP2861063A1 (en) 2015-04-22
US20180360007A1 (en) 2018-12-20
US9974291B2 (en) 2018-05-22
JP2015523863A (ja) 2015-08-20
US9232776B2 (en) 2016-01-12
BR112014029892A2 (pt) 2017-07-25
EP2859793B1 (en) 2017-04-05
MX363540B (es) 2019-03-27
US20170064932A1 (en) 2017-03-09
IL260250B (en) 2019-08-29
CN104378976A (zh) 2015-02-25
IL235773B (en) 2018-07-31
RU2654565C2 (ru) 2018-05-21
CN105779467A (zh) 2016-07-20
AU2013277457A1 (en) 2015-01-22
SI2859793T1 (sl) 2017-07-31
IL268674A (en) 2019-10-31
US20150082469A1 (en) 2015-03-19
HUE034592T2 (en) 2018-02-28
US9737059B2 (en) 2017-08-22
CN104378976B (zh) 2016-03-23
SG11201407370QA (en) 2014-12-30
LT2859793T (lt) 2017-07-10
PT2859793T (pt) 2017-07-06
PL2859793T3 (pl) 2017-09-29
DK2859793T3 (en) 2017-06-19
SG10201609569PA (en) 2016-12-29
ES2626965T3 (es) 2017-07-26
IN2014DN10189A (fi) 2015-08-21
MX2014015679A (es) 2015-04-08
JP6174134B2 (ja) 2017-08-02
HK1203761A1 (en) 2015-11-06
EP2859793A1 (en) 2015-04-15
US20170311581A1 (en) 2017-11-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210613