HK1202549A1 - 多奈哌齊雙羥萘酸鹽、製備方法及其應用 - Google Patents

多奈哌齊雙羥萘酸鹽、製備方法及其應用

Info

Publication number
HK1202549A1
HK1202549A1 HK15103237.0A HK15103237A HK1202549A1 HK 1202549 A1 HK1202549 A1 HK 1202549A1 HK 15103237 A HK15103237 A HK 15103237A HK 1202549 A1 HK1202549 A1 HK 1202549A1
Authority
HK
Hong Kong
Prior art keywords
preparation
donepezil pamoate
donepezil
pamoate
Prior art date
Application number
HK15103237.0A
Other languages
English (en)
Inventor
Ziqiang Gu
Original Assignee
Ziqiang Gu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ziqiang Gu filed Critical Ziqiang Gu
Publication of HK1202549A1 publication Critical patent/HK1202549A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HK15103237.0A 2011-11-29 2015-03-31 多奈哌齊雙羥萘酸鹽、製備方法及其應用 HK1202549A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2011/083117 WO2013078608A1 (en) 2011-11-29 2011-11-29 Donepezil pamoate and methods of making and using the same
PCT/CN2012/085534 WO2013079007A1 (en) 2011-11-29 2012-11-29 Donepezil pamoate, preparation methode and its use

Publications (1)

Publication Number Publication Date
HK1202549A1 true HK1202549A1 (zh) 2015-10-02

Family

ID=48534596

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103237.0A HK1202549A1 (zh) 2011-11-29 2015-03-31 多奈哌齊雙羥萘酸鹽、製備方法及其應用

Country Status (5)

Country Link
US (5) US9353059B2 (zh)
EP (1) EP2785691B1 (zh)
ES (1) ES2702541T3 (zh)
HK (1) HK1202549A1 (zh)
WO (2) WO2013078608A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0917862A2 (pt) * 2008-09-30 2015-11-24 Teikoku Pharma Usa Inc composições transdérmicas de donepezil com distribuição prolongada e métodos para usar as mesmas
KR101811797B1 (ko) * 2013-04-03 2017-12-22 동국제약 주식회사 도네페질을 포함하는 비경구투여용 약제학적 조성물
WO2018153315A1 (zh) 2017-02-23 2018-08-30 上海华汇拓医药科技有限公司 一种多奈哌齐半帕莫酸盐的粉针剂、包含其的组合物及它们的制备方法
CN108976163B (zh) * 2017-06-05 2023-08-11 上海奥博生物医药股份有限公司 一种多奈哌齐双羟萘酸盐新的制备方法
US11234961B2 (en) 2017-08-17 2022-02-01 Zi-Qiang Gu Pamoate salt of monoamine anti-Parkinson's agents, method of preparation and use thereof
WO2019045355A1 (ko) * 2017-08-29 2019-03-07 대원제약 주식회사 리바스티그민 파모산염의 제조방법
CN111818914A (zh) 2017-12-13 2020-10-23 考里安公司 透皮药物递送期间创建储库的方法
CA3143471C (en) * 2019-07-12 2023-10-31 Heeyong Lee Long-lasting formulation containing rivastigmine, and method for preparing same
KR102593114B1 (ko) * 2020-05-11 2023-10-24 주식회사 아울바이오 약물 봉입률과 지속방출능력이 향상된 미립구 및 이의 제조방법
KR20210158232A (ko) * 2020-06-23 2021-12-30 주식회사 아울바이오 치매치료를 위한 장기지속형 주사제
KR102227100B1 (ko) * 2020-08-14 2021-03-12 주식회사 종근당 도네페질 에테르 팔미테이트 또는 이의 약제학적으로 허용가능한 염
CN114014763A (zh) * 2021-09-30 2022-02-08 天津大学 一种美金刚双羟萘酸盐晶体及其制备方法和应用
CN113831251A (zh) * 2021-09-30 2021-12-24 江南大学 一种美金刚双羟萘酸盐晶体及其制备方法和应用
CN113861039A (zh) * 2021-09-30 2021-12-31 江南大学 一种美金刚双羟萘酸盐晶体及其制备方法和应用
CN113845429A (zh) * 2021-09-30 2021-12-28 天津大学 一种美金刚双羟萘酸盐晶体及其制备方法和应用
WO2023249461A1 (ko) * 2022-06-23 2023-12-28 주식회사 지투지바이오 도네페질과 파모산을 함유하는 서방성 미립구
WO2023249464A1 (ko) * 2022-06-23 2023-12-28 주식회사 지투지바이오 약물과 파모산을 함유하는 서방성 미립구

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CN1204319A (zh) 1995-12-15 1999-01-06 辉瑞大药厂 制备1－苄基－4－(5,6－二甲氧基－1－二氢化茚酮)－2－基)甲基哌啶的方法和中间体
JP3066083B2 (ja) * 1995-12-15 2000-07-17 ファイザー インク． １―ベンジル―４―（（５，６―ジメトキシ―１―インダノン）―２―イル）メチルピペリジンを調製する方法及びそのための中間物質
CA2304568C (en) * 1997-09-30 2008-08-12 Eli Lilly And Company Olanzapine pamoate formulations
EP1595535A2 (en) * 2002-12-23 2005-11-16 Osmotica Costa Rica Sociedad Anonima Delivery device containing venlafaxine and memantine and use method thereof
US20050232990A1 (en) * 2003-12-31 2005-10-20 Garth Boehm Donepezil formulations
HUP0401850A3 (en) 2004-09-15 2008-03-28 Egis Gyogyszergyar Nyilvanosan Donepezil salts for producing pharmaceutical composition
US20080171736A1 (en) * 2004-12-23 2008-07-17 Gregory Christopher W Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists
CN101090737B (zh) 2004-12-27 2010-09-08 卫材R&D管理有限公司 稳定抗痴呆药物的方法
US20080090808A1 (en) * 2006-10-17 2008-04-17 Franklin Volvovitz Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
BRPI0917862A2 (pt) 2008-09-30 2015-11-24 Teikoku Pharma Usa Inc composições transdérmicas de donepezil com distribuição prolongada e métodos para usar as mesmas
CN101708164A (zh) 2009-12-18 2010-05-19 苏州大学 一种卡巴拉汀缓释微球及其制备方法
US20110218216A1 (en) 2010-01-29 2011-09-08 Kumaravel Vivek Extended release pharmaceutical composition of donepezil
CN102552218A (zh) * 2010-12-31 2012-07-11 无锡万全医药技术有限公司 一种盐酸美金刚胶囊缓释剂及其制备方法
US20140243278A1 (en) * 2011-07-05 2014-08-28 Sunil Sadanand Nadkarni Acid Addition Salt of Donepezil and Pharmaceutical Composition Thereof

Also Published As

Publication number Publication date
US20190274955A1 (en) 2019-09-12
US20140315952A1 (en) 2014-10-23
EP2785691B1 (en) 2018-09-26
US20200129423A1 (en) 2020-04-30
ES2702541T3 (es) 2019-03-01
EP2785691A1 (en) 2014-10-08
WO2013079007A1 (en) 2013-06-06
US9353059B2 (en) 2016-05-31
WO2013078608A1 (en) 2013-06-06
US20180104179A1 (en) 2018-04-19
US10272031B2 (en) 2019-04-30
EP2785691A4 (en) 2015-09-30
US10478395B2 (en) 2019-11-19
US10952958B2 (en) 2021-03-23
US20160310411A1 (en) 2016-10-27

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