HK1202291A1 - 異喹啉和二氮雜萘衍生物 - Google Patents
異喹啉和二氮雜萘衍生物Info
- Publication number
- HK1202291A1 HK1202291A1 HK15102728.8A HK15102728A HK1202291A1 HK 1202291 A1 HK1202291 A1 HK 1202291A1 HK 15102728 A HK15102728 A HK 15102728A HK 1202291 A1 HK1202291 A1 HK 1202291A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- isoquinoline
- naphthyridine derivatives
- naphthyridine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261592443P | 2012-01-30 | 2012-01-30 | |
US201261593775P | 2012-02-01 | 2012-02-01 | |
US201261701916P | 2012-09-17 | 2012-09-17 | |
PCT/EP2013/051613 WO2013113669A1 (en) | 2012-01-30 | 2013-01-29 | Isoquinoline and naphthyridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1202291A1 true HK1202291A1 (zh) | 2015-09-25 |
Family
ID=47666117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102728.8A HK1202291A1 (zh) | 2012-01-30 | 2015-03-17 | 異喹啉和二氮雜萘衍生物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US9586956B2 (zh) |
EP (1) | EP2809652B1 (zh) |
JP (1) | JP6363020B2 (zh) |
KR (1) | KR20140117651A (zh) |
CN (1) | CN104334532B (zh) |
BR (1) | BR112014018670A8 (zh) |
CA (1) | CA2863132A1 (zh) |
HK (1) | HK1202291A1 (zh) |
MX (1) | MX353190B (zh) |
RU (1) | RU2014133390A (zh) |
WO (1) | WO2013113669A1 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016511237A (ja) * | 2013-02-01 | 2016-04-14 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | 選択的hdac3阻害剤 |
EP3233797B1 (en) * | 2015-01-18 | 2019-05-08 | SRI International Inc. | Map4k4 (hgk) inhibitors |
EP3694866A1 (en) * | 2017-10-13 | 2020-08-19 | Imperial College Of Science, Technology And Medicine | Map4k4 inhibitors |
GB201819839D0 (en) * | 2018-12-05 | 2019-01-23 | Imperial Innovations Ltd | MAP4K4 inhibitors |
CN110028432A (zh) * | 2019-05-22 | 2019-07-19 | 南京合巨药业有限公司 | 一种(3-氨基-氮杂环丁烷-1-基)-环丙基-甲酮的制备方法 |
CN110066259A (zh) * | 2019-05-22 | 2019-07-30 | 南京合巨药业有限公司 | 一种n-环戊基-1,1-二氧代-4-硫代吗啉甲酰胺的合成方法 |
GB201915829D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
GB201915831D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
CN117279896A (zh) * | 2021-04-07 | 2023-12-22 | 劲方医药科技(上海)有限公司 | 氨基取代的吡啶并环类化合物及其制法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE60009888T2 (de) * | 1999-04-21 | 2005-04-21 | Wyeth Corp | Substituierte 3-cyano-[1.7], [1.5] und [1.8]naphthyridininhibitoren von tyrosin kinasen |
PE20050952A1 (es) | 2003-09-24 | 2005-12-19 | Novartis Ag | Derivados de isoquinolina como inhibidores de b-raf |
RU2009122670A (ru) * | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
WO2010111527A1 (en) * | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
-
2013
- 2013-01-29 JP JP2014553751A patent/JP6363020B2/ja not_active Expired - Fee Related
- 2013-01-29 CA CA2863132A patent/CA2863132A1/en not_active Abandoned
- 2013-01-29 WO PCT/EP2013/051613 patent/WO2013113669A1/en active Application Filing
- 2013-01-29 MX MX2014009180A patent/MX353190B/es active IP Right Grant
- 2013-01-29 EP EP13702781.9A patent/EP2809652B1/en active Active
- 2013-01-29 RU RU2014133390A patent/RU2014133390A/ru not_active Application Discontinuation
- 2013-01-29 BR BR112014018670A patent/BR112014018670A8/pt not_active IP Right Cessation
- 2013-01-29 CN CN201380013877.8A patent/CN104334532B/zh not_active Expired - Fee Related
- 2013-01-29 KR KR1020147024093A patent/KR20140117651A/ko not_active Application Discontinuation
-
2014
- 2014-07-31 US US14/448,941 patent/US9586956B2/en active Active
-
2015
- 2015-03-17 HK HK15102728.8A patent/HK1202291A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20140343036A1 (en) | 2014-11-20 |
CA2863132A1 (en) | 2013-08-08 |
MX2014009180A (es) | 2014-10-13 |
BR112014018670A2 (zh) | 2017-06-20 |
MX353190B (es) | 2018-01-05 |
JP6363020B2 (ja) | 2018-07-25 |
BR112014018670A8 (pt) | 2017-07-11 |
CN104334532B (zh) | 2018-08-14 |
US9586956B2 (en) | 2017-03-07 |
JP2015509921A (ja) | 2015-04-02 |
WO2013113669A1 (en) | 2013-08-08 |
RU2014133390A (ru) | 2016-03-20 |
KR20140117651A (ko) | 2014-10-07 |
CN104334532A (zh) | 2015-02-04 |
EP2809652A1 (en) | 2014-12-10 |
EP2809652B1 (en) | 2019-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230131 |