HK1201835A1 - 可溶性環氧化物水解酶的酰基哌啶抑制劑 - Google Patents

可溶性環氧化物水解酶的酰基哌啶抑制劑

Info

Publication number
HK1201835A1
HK1201835A1 HK15102406.7A HK15102406A HK1201835A1 HK 1201835 A1 HK1201835 A1 HK 1201835A1 HK 15102406 A HK15102406 A HK 15102406A HK 1201835 A1 HK1201835 A1 HK 1201835A1
Authority
HK
Hong Kong
Prior art keywords
epoxide hydrolase
soluble epoxide
acyl piperidine
inhibitors
piperidine inhibitors
Prior art date
Application number
HK15102406.7A
Other languages
English (en)
Inventor
‧哈莫克
‧李
‧莫里西佑
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HK1201835A1 publication Critical patent/HK1201835A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y303/00—Hydrolases acting on ether bonds (3.3)
    • C12Y303/02—Ether hydrolases (3.3.2)
    • C12Y303/0201—Soluble epoxide hydrolase (3.3.2.10)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15102406.7A 2012-02-01 2015-03-10 可溶性環氧化物水解酶的酰基哌啶抑制劑 HK1201835A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261593805P 2012-02-01 2012-02-01
PCT/US2013/024396 WO2013116690A1 (en) 2012-02-01 2013-02-01 Acyl piperidine inhibitors of soluble epoxide hydrolase

Publications (1)

Publication Number Publication Date
HK1201835A1 true HK1201835A1 (zh) 2015-09-11

Family

ID=48905886

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102406.7A HK1201835A1 (zh) 2012-02-01 2015-03-10 可溶性環氧化物水解酶的酰基哌啶抑制劑

Country Status (5)

Country Link
US (1) US9034903B2 (zh)
EP (1) EP2809650B1 (zh)
CN (1) CN104093708B (zh)
HK (1) HK1201835A1 (zh)
WO (1) WO2013116690A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016021641A2 (pt) * 2014-03-27 2017-08-15 Eicosis Llc Potentes inibidores da epóxido hidrolase solúveis
WO2015188060A1 (en) * 2014-06-06 2015-12-10 The Scripps Research Institute FLUOROSULFONYL sEH INHIBITORS
US10813894B2 (en) 2015-02-20 2020-10-27 The Regents Of The University Of California Methods of inhibiting pain
EP3584236A1 (en) * 2018-06-20 2019-12-25 Universitat de Barcelona Polycyclic compounds soluble epoxide hydrolase inhibitors
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain
CN116589606B (zh) * 2022-12-01 2024-05-28 中国药科大学 一种丁酰化酵母葡聚糖及其制备方法、应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US5445956A (en) 1993-08-13 1995-08-29 The Regents Of The University Of California Recombinant soluble epoxide hydrolase
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US6150415A (en) 1996-08-13 2000-11-21 The Regents Of The University Of California Epoxide hydrolase complexes and methods therewith
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
CA2340652C (en) 1998-08-20 2013-09-24 Cook Incorporated Coated implantable medical device comprising paclitaxel
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6156373A (en) 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6290722B1 (en) 2000-03-13 2001-09-18 Endovascular Technologies, Inc. Tacky attachment method of covered materials on stents
CA2584342C (en) 2004-10-20 2013-04-30 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
AU2007309117A1 (en) * 2006-10-20 2008-05-02 Arete Therapeutics, Inc. Phenylurea compounds as soluble epoxide hydrolase inhibitors
CN101535259A (zh) * 2006-10-20 2009-09-16 亚瑞特医疗公司 作为可溶性环氧化物水解酶抑制剂的苯基脲化合物
EA200901240A1 (ru) * 2007-03-13 2010-02-26 Эрет Терэпьютикс, Инк. Соединения 4-пиперидинилмочевины (варианты), фармацевтическая композиция на их основе (варианты) и способ лечения заболевания, опосредованного растворимой эпоксидгидролазой, посредством названных соединений (варианты)
US20090247521A1 (en) 2007-12-28 2009-10-01 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors for the treatment of endothelial dysfunction
US20090270452A1 (en) 2008-04-18 2009-10-29 Arete Therapeutics, Inc. Use of soluble epoxide hydrolase inhibitors in the treatment of smooth muscle disorders
US20100063583A1 (en) 2008-08-29 2010-03-11 Arete Therapeutics, Inc. Use of soluble epoxide hydrolase inhibitors in the treatment of inflammatory vascular diseases
US9296693B2 (en) * 2010-01-29 2016-03-29 The Regents Of The University Of California Acyl piperidine inhibitors of soluble epoxide hydrolase
EP2809314A4 (en) * 2012-02-01 2015-07-08 Univ California TREATMENT OF NEUROPATHIC PAIN WITH SEH INHIBITORS

Also Published As

Publication number Publication date
EP2809650A4 (en) 2015-08-19
US20150011586A1 (en) 2015-01-08
CN104093708A (zh) 2014-10-08
CN104093708B (zh) 2016-11-09
US9034903B2 (en) 2015-05-19
EP2809650A1 (en) 2014-12-10
WO2013116690A1 (en) 2013-08-08
EP2809650B1 (en) 2018-04-11

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