HK1201560A1 - Reduced genome bacteria with improved genetic stability - Google Patents

Reduced genome bacteria with improved genetic stability

Info

Publication number
HK1201560A1
HK1201560A1 HK15102152.3A HK15102152A HK1201560A1 HK 1201560 A1 HK1201560 A1 HK 1201560A1 HK 15102152 A HK15102152 A HK 15102152A HK 1201560 A1 HK1201560 A1 HK 1201560A1
Authority
HK
Hong Kong
Prior art keywords
genetic stability
improved genetic
reduced genome
genome bacteria
bacteria
Prior art date
Application number
HK15102152.3A
Other languages
English (en)
Chinese (zh)
Inventor
Frederick R Blattner
Balint Csorgo
Gyorgy Posfai
Original Assignee
Scarab Genomics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scarab Genomics Llc filed Critical Scarab Genomics Llc
Publication of HK1201560A1 publication Critical patent/HK1201560A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/08—Reducing the nucleic acid content
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK15102152.3A 2011-10-20 2015-03-04 Reduced genome bacteria with improved genetic stability HK1201560A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549375P 2011-10-20 2011-10-20
PCT/US2012/061027 WO2013059595A1 (en) 2011-10-20 2012-10-19 Reduced genome bacteria with improved genetic stability

Publications (1)

Publication Number Publication Date
HK1201560A1 true HK1201560A1 (en) 2015-09-04

Family

ID=47178310

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102152.3A HK1201560A1 (en) 2011-10-20 2015-03-04 Reduced genome bacteria with improved genetic stability

Country Status (9)

Country Link
US (1) US9340791B2 (xx)
EP (1) EP2768943B1 (xx)
JP (2) JP6151704B2 (xx)
KR (1) KR102043891B1 (xx)
CN (1) CN104024398B (xx)
AU (1) AU2012325917B2 (xx)
CA (1) CA2850842C (xx)
HK (1) HK1201560A1 (xx)
WO (1) WO2013059595A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012325917B2 (en) * 2011-10-20 2018-04-12 Scarab Genomics, Llc Reduced genome bacteria with improved genetic stability
EP3068887B1 (en) * 2013-11-14 2019-10-30 Scarab Genomics LLC Bacteria with improved metabolic capacity
EP3113800B1 (en) * 2014-03-03 2024-06-19 Scarab Genomics, LLC Enhanced production of recombinant crm197 in e. coli
CA2981583C (en) * 2015-04-02 2022-11-15 Scarab Genomics, Llc Continuous fermentation process for production of biological product using reduced genome escherichia coli
CN108587992B (zh) * 2018-04-10 2022-03-15 安徽大学 一种高效分泌表达抗VEGF-Fab抗体片段的高产菌株及其构建方法
CN111019877B (zh) * 2019-12-31 2022-04-19 浙江工业大学 一种产l-半胱氨酸的基因工程菌、构建方法及应用
WO2022256427A1 (en) * 2021-06-01 2022-12-08 University Of Virginia Patent Foundation Minicells from highly genome reduced escherichia coli: cytoplasmic and surface expression of recombinant proteins and incorporation in the minicells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578464A (en) 1989-10-31 1996-11-26 Schering Corporation E. coli secretory strains
US5747662A (en) 1995-03-01 1998-05-05 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6022952A (en) 1998-04-01 2000-02-08 University Of Alberta Compositions and methods for protein secretion
US20060270043A1 (en) 2002-01-23 2006-11-30 Blattner Frederick R Bacteria with reduced genome
US8119365B2 (en) * 2002-01-23 2012-02-21 Wisconsin Alumni Research Foundation Insertion sequence-free bacteria
US8039243B2 (en) 2002-01-23 2011-10-18 Wisconsin Alumni Research Foundation Insertion sequence-free bacteria
US6989265B2 (en) 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
CA2626900C (en) 2005-08-20 2013-07-23 Scarab Genomics, Llc Reduced genome e. coli
WO2010093708A1 (en) * 2009-02-12 2010-08-19 Scarab Genomics Llc Compositions comprising reduced genome bacteria for use in treatment of sepsis
AU2012325917B2 (en) * 2011-10-20 2018-04-12 Scarab Genomics, Llc Reduced genome bacteria with improved genetic stability

Also Published As

Publication number Publication date
CN104024398A (zh) 2014-09-03
JP2014530625A (ja) 2014-11-20
CN104024398B (zh) 2016-10-05
WO2013059595A1 (en) 2013-04-25
EP2768943A1 (en) 2014-08-27
JP2017169582A (ja) 2017-09-28
CA2850842C (en) 2021-06-08
AU2012325917B2 (en) 2018-04-12
CA2850842A1 (en) 2013-04-25
US9340791B2 (en) 2016-05-17
JP6539691B2 (ja) 2019-07-03
JP6151704B2 (ja) 2017-06-21
US20140302555A1 (en) 2014-10-09
EP2768943B1 (en) 2017-06-21
KR102043891B1 (ko) 2019-11-12
AU2012325917A1 (en) 2014-04-17
KR20140076628A (ko) 2014-06-20

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