HK1200439A1 - Derivatives of 1-(2-halo-biphenyl-4-yl)-alkanecarboxylic acids for the treatment of neurodegenerative diseases 1-(2---4-)- - Google Patents

Derivatives of 1-(2-halo-biphenyl-4-yl)-alkanecarboxylic acids for the treatment of neurodegenerative diseases 1-(2---4-)-

Info

Publication number
HK1200439A1
HK1200439A1 HK15100809.4A HK15100809A HK1200439A1 HK 1200439 A1 HK1200439 A1 HK 1200439A1 HK 15100809 A HK15100809 A HK 15100809A HK 1200439 A1 HK1200439 A1 HK 1200439A1
Authority
HK
Hong Kong
Prior art keywords
biphenyl
halo
derivatives
treatment
neurodegenerative diseases
Prior art date
Application number
HK15100809.4A
Other languages
English (en)
Chinese (zh)
Inventor
‧茵碧波
‧拉維基裡亞
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of HK1200439A1 publication Critical patent/HK1200439A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK15100809.4A 2012-04-04 2015-01-23 Derivatives of 1-(2-halo-biphenyl-4-yl)-alkanecarboxylic acids for the treatment of neurodegenerative diseases 1-(2---4-)- HK1200439A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12163074 2012-04-04
PCT/EP2013/057025 WO2013150072A1 (en) 2012-04-04 2013-04-03 Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
HK1200439A1 true HK1200439A1 (en) 2015-08-07

Family

ID=48227176

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100809.4A HK1200439A1 (en) 2012-04-04 2015-01-23 Derivatives of 1-(2-halo-biphenyl-4-yl)-alkanecarboxylic acids for the treatment of neurodegenerative diseases 1-(2---4-)-

Country Status (10)

Country Link
US (1) US8835494B2 (ko)
EP (1) EP2834214A1 (ko)
KR (1) KR20140144178A (ko)
CN (1) CN104169251A (ko)
AR (1) AR090581A1 (ko)
BR (1) BR112014023670A8 (ko)
CA (1) CA2869418A1 (ko)
HK (1) HK1200439A1 (ko)
RU (1) RU2014139971A (ko)
WO (1) WO2013150072A1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015181094A1 (en) * 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409176T1 (de) 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
PT1778623E (pt) 2004-08-03 2008-09-29 Chiesi Farma Spa Derivados dos ácidos 1-fenilalcanocarboxílicos para o tratamento de doenças neurodegenerativas
EP2133322A1 (en) 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
CN102596879B (zh) 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法

Also Published As

Publication number Publication date
WO2013150072A1 (en) 2013-10-10
US8835494B2 (en) 2014-09-16
RU2014139971A (ru) 2016-04-20
CA2869418A1 (en) 2013-10-10
AR090581A1 (es) 2014-11-19
KR20140144178A (ko) 2014-12-18
BR112014023670A2 (ko) 2017-06-20
CN104169251A (zh) 2014-11-26
US20130267592A1 (en) 2013-10-10
BR112014023670A8 (pt) 2017-07-25
EP2834214A1 (en) 2015-02-11

Similar Documents

Publication Publication Date Title
HRP20190491T1 (hr) Spojevi 1-arilkarbonil-4-oksi-piperidina korisni za liječenje neurodegenerativnih bolesti
IL235767A0 (en) Converted pyrrolidines as factor xia inhibitors for the treatment of thromboembolic diseases
IL239368A0 (en) Sparing–ppar thiazolidinediones and combinations for the treatment of neurodegenerative diseases of the nervous system
GB201021103D0 (en) New compounds for the treatment of neurodegenerative diseases
EP2906583A4 (en) PEPTIDES FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
HK1205502A1 (en) Compounds for the treatment of mtor pathway related diseases mtor
EP3013824B8 (en) Carboline compounds usable in the treatment of neurodegenerative diseases
HK1216504A1 (zh) 疾病的治療方法
ZA201309554B (en) Compounds and pharmaceutical combinations for the treatment of neurodegenerative and ischemic brain diseases
IL238592B (en) Compounds for the treatment of liver diseases
ZA201603117B (en) Withanolides useful for the treatment of neurodegenerative diseases
EP2925755A4 (en) NEUROPROTECTIVE AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
EP2739304A4 (en) PARTICLES FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
IL234796B (en) Compounds for the treatment of diseases related to ischemia-reperfusion
HK1208454A1 (zh) 治療細菌性疾病的嘧啶衍生物
HK1200439A1 (en) Derivatives of 1-(2-halo-biphenyl-4-yl)-alkanecarboxylic acids for the treatment of neurodegenerative diseases 1-(2---4-)-
PL395469A1 (pl) Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
PL2692355T3 (pl) Apolaktoferyna do zastosowania w leczeniu chorób związanych z akumulacją żelaza
GB201317550D0 (en) Use of Enalaprilat for treatment of neurodegenerative diseases