HK1183867A1 - Benzazole derivatives as histamine h4 receptor ligands h4 - Google Patents

Benzazole derivatives as histamine h4 receptor ligands h4

Info

Publication number
HK1183867A1
HK1183867A1 HK13111288.3A HK13111288A HK1183867A1 HK 1183867 A1 HK1183867 A1 HK 1183867A1 HK 13111288 A HK13111288 A HK 13111288A HK 1183867 A1 HK1183867 A1 HK 1183867A1
Authority
HK
Hong Kong
Prior art keywords
histamine
receptor ligands
benzazole derivatives
benzazole
derivatives
Prior art date
Application number
HK13111288.3A
Other languages
English (en)
Chinese (zh)
Inventor
Isabelle Berrebi-Bertrand
Xavier Billot
Thierry Calmels
Marc Capet
Denis Danvy
Stphane Krief
Olivier Labeeuw
Jeanne-Marie Lecomte
Nicolas Levoin
Xavier Ligneau
Philippe Robert
Jean-Charles Schwartz
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of HK1183867A1 publication Critical patent/HK1183867A1/xx

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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HK13111288.3A 2010-09-27 2013-10-04 Benzazole derivatives as histamine h4 receptor ligands h4 HK1183867A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20100306038 EP2447263A1 (fr) 2010-09-27 2010-09-27 Dérivés de benzazole en tant que ligands du récepteur H4
PCT/EP2011/066782 WO2012041860A1 (fr) 2010-09-27 2011-09-27 Utilisation de dérivés de benzazole en tant que ligands des récepteurs h4 de l'histamine

Publications (1)

Publication Number Publication Date
HK1183867A1 true HK1183867A1 (en) 2014-01-10

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HK13111288.3A HK1183867A1 (en) 2010-09-27 2013-10-04 Benzazole derivatives as histamine h4 receptor ligands h4

Country Status (17)

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US (2) US8802664B2 (fr)
EP (2) EP2447263A1 (fr)
JP (1) JP5922128B2 (fr)
CN (1) CN103228643B (fr)
CA (1) CA2812686C (fr)
CY (1) CY1117416T1 (fr)
DK (1) DK2621916T3 (fr)
ES (1) ES2571335T3 (fr)
HK (1) HK1183867A1 (fr)
HR (1) HRP20160398T1 (fr)
HU (1) HUE027252T2 (fr)
MX (1) MX339460B (fr)
PL (1) PL2621916T3 (fr)
RS (1) RS54737B1 (fr)
SI (1) SI2621916T1 (fr)
SM (1) SMT201600262B (fr)
WO (1) WO2012041860A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5991553B2 (ja) 2011-04-19 2016-09-14 サウジ ベーシック インダストリーズ コーポレイションＳａｕｄｉ Ｂａｓｉｃ Ｉｎｄｕｓｔｒｉｅｓ Ｃｏｒｐｏｒａｉｔｏｎ 炭素担持コバルト及びモリブデン触媒
PE20150623A1 (es) * 2012-05-04 2015-05-17 Novartis Ag Moduladores de la ruta del complemento y usos de los mismos
EP2671870A1 (fr) 2012-06-05 2013-12-11 Bioprojet Nouveaux dérivés d'éther (aza)benzhydryle, leur procédé de préparation et leur utilisation en tant que ligands du récepteur H4 pour applications thérapeutiques
JP6185574B2 (ja) 2012-06-08 2017-08-23 センソリオン 耳鳴りを治療するためのｈ４受容体阻害剤
CN104710341A (zh) * 2015-02-13 2015-06-17 佛山市赛维斯医药科技有限公司 一类含双酰肼和萘基结构的化合物、制备方法及其用途
WO2019051469A1 (fr) * 2017-09-11 2019-03-14 Krouzon Pharmaceuticals, Inc. Inhibiteurs allostériques octahydrocyclopenta[c]pyrrole de shp2
BR102018073582A2 (pt) * 2017-11-15 2020-07-07 Bioprojet Enantiômero, processo de preparação de um enantiômero, uso do enantiômero, composição farmacêutica e combinação
CN113278409B (zh) * 2021-06-22 2022-04-29 西南石油大学 一种高温酸化缓蚀剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI803127L (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterocykliska foereningar
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JPH05339266A (ja) * 1992-06-05 1993-12-21 Kaken Pharmaceut Co Ltd 新規なピペリジン誘導体
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
RU2325387C2 (ru) 2001-12-21 2008-05-27 Анормед Инк. Гетероциклические соединения с повышенной эффективностью, связывающиеся с рецептором хемокина
US20060127404A1 (en) * 2003-09-30 2006-06-15 Chichi Huang Hinge core mimetibodies, compositions, methods and uses
RU2006110561A (ru) * 2003-09-30 2007-10-10 Янссен Фармацевтика Н.В. (Be) Соединения бензоимидазола
EP1642577A1 (fr) * 2004-09-07 2006-04-05 Laboratorios del Dr. Esteve S.A. Des derives d'aryl(ou heteroaryl) azolylcarbinoles pour le traitement de la douleur neuropathique centrale
WO2006107784A1 (fr) 2005-04-05 2006-10-12 Eli Lilly And Company Composes d’imidazopyridazine
US8163901B2 (en) 2008-01-09 2012-04-24 Evotec Ag Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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CN103228643A (zh) 2013-07-31
HRP20160398T1 (hr) 2016-05-20
US20150004181A1 (en) 2015-01-01
SMT201600262B (it) 2016-08-31
SI2621916T1 (sl) 2016-06-30
DK2621916T3 (en) 2016-04-18
ES2571335T3 (es) 2016-05-24
EP2621916A1 (fr) 2013-08-07
MX2013003479A (es) 2013-06-24
US9029357B2 (en) 2015-05-12
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CN103228643B (zh) 2015-11-25
US20130231329A1 (en) 2013-09-05
CA2812686C (fr) 2019-04-02
MX339460B (es) 2016-05-27
JP5922128B2 (ja) 2016-05-24
EP2447263A1 (fr) 2012-05-02
CY1117416T1 (el) 2017-04-26
CA2812686A1 (fr) 2012-04-05
EP2621916B1 (fr) 2016-02-10
RS54737B1 (sr) 2016-10-31
US8802664B2 (en) 2014-08-12
JP2013537898A (ja) 2013-10-07
WO2012041860A1 (fr) 2012-04-05

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