HK1180012A1 - High-affinity nucleic acid aptamers against sclerostin protein - Google Patents

High-affinity nucleic acid aptamers against sclerostin protein

Info

Publication number
HK1180012A1
HK1180012A1 HK13107326.5A HK13107326A HK1180012A1 HK 1180012 A1 HK1180012 A1 HK 1180012A1 HK 13107326 A HK13107326 A HK 13107326A HK 1180012 A1 HK1180012 A1 HK 1180012A1
Authority
HK
Hong Kong
Prior art keywords
nucleic acid
acid aptamers
affinity nucleic
aptamers against
sclerostin protein
Prior art date
Application number
HK13107326.5A
Other languages
English (en)
Chinese (zh)
Inventor
Julian Alexander Tanner
Kato Shum
Szelai Celine Chan
Original Assignee
香港大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 香港大學 filed Critical 香港大學
Publication of HK1180012A1 publication Critical patent/HK1180012A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK13107326.5A 2010-05-27 2013-06-24 High-affinity nucleic acid aptamers against sclerostin protein HK1180012A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34905810P 2010-05-27 2010-05-27
PCT/CN2011/000879 WO2011147193A1 (en) 2010-05-27 2011-05-23 High-affinity nucleic acid aptamers against sclerostin protein

Publications (1)

Publication Number Publication Date
HK1180012A1 true HK1180012A1 (en) 2013-10-11

Family

ID=45003261

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13107326.5A HK1180012A1 (en) 2010-05-27 2013-06-24 High-affinity nucleic acid aptamers against sclerostin protein

Country Status (5)

Country Link
US (1) US8552166B2 (xx)
EP (1) EP2576786B1 (xx)
CN (1) CN102971424B (xx)
HK (1) HK1180012A1 (xx)
WO (1) WO2011147193A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2812453B1 (en) * 2012-02-09 2017-09-27 The University of Hong Kong Nucleic acid aptamers against plasmodium lactate dehydrogenase and histidine-rich protein ii and uses thereof for malaria diagnosis
CN104212800B (zh) * 2013-05-07 2017-01-18 南方医科大学 一种与人表皮生长因子受体iii型突变体特异性结合的核酸适配子及其应用
TWI482857B (zh) 2013-10-21 2015-05-01 Nat Univ Tsing Hua 針對糖化血紅素及血紅素具有高專一性的適合體及其應用
TWI480374B (zh) 2013-10-23 2015-04-11 Nat Univ Tsing Hua 針對ａ型流感ｈ１亞型病毒具有高專一性的適合體及其應用
CA2993652A1 (en) * 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
EP3754021A4 (en) * 2018-02-12 2021-11-10 Aptacure Therapeutics Limited APTAMER FOR SCLEROSTIN AND USE OF IT
WO2020163974A1 (zh) * 2019-02-11 2020-08-20 深圳欣沛生物医药技术服务有限公司 针对骨硬化蛋白的适体的诊断用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125542B2 (en) * 2000-02-10 2006-10-24 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
MEP2808A (xx) * 2003-06-16 2010-02-10 Celltech R & D Inc Antitijela specifična za sklerositin i metode za povećanje mineralizacije kostiju
US8367822B2 (en) * 2003-09-22 2013-02-05 Enzo Therapeutics, Inc. Compositions and methods for bone formation and remodeling
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
WO2006135734A2 (en) * 2005-06-10 2006-12-21 The Regents Of The University Of California Compositions and methods for altering bone density and bone patterning
CN101301478A (zh) * 2007-05-10 2008-11-12 贝勒医学院 以低氧诱导因子1-α(HIF1α)作为靶标的G-四合体寡核苷酸

Also Published As

Publication number Publication date
CN102971424B (zh) 2014-11-12
US20110294872A1 (en) 2011-12-01
EP2576786B1 (en) 2016-04-06
CN102971424A (zh) 2013-03-13
EP2576786A4 (en) 2014-11-26
EP2576786A1 (en) 2013-04-10
WO2011147193A1 (en) 2011-12-01
US8552166B2 (en) 2013-10-08

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