HK1177749A1 - 空間構象改變的重組干擾素的晶體、其三維結構及應用 - Google Patents
空間構象改變的重組干擾素的晶體、其三維結構及應用Info
- Publication number
- HK1177749A1 HK1177749A1 HK13104725.9A HK13104725A HK1177749A1 HK 1177749 A1 HK1177749 A1 HK 1177749A1 HK 13104725 A HK13104725 A HK 13104725A HK 1177749 A1 HK1177749 A1 HK 1177749A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dimensional structure
- spatial configuration
- recombinant interferon
- altered spatial
- crystalline recombinant
- Prior art date
Links
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- G—PHYSICS
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- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102593392A CN102101886A (zh) | 2009-12-18 | 2009-12-18 | 构象改变的重组干扰素晶体、其三维结构及应用 |
PCT/CN2010/002055 WO2011072487A1 (zh) | 2009-12-18 | 2010-12-16 | 空间构象改变的重组干扰素的晶体、其三维结构及应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1177749A1 true HK1177749A1 (zh) | 2013-08-30 |
Family
ID=44154975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13104725.9A HK1177749A1 (zh) | 2009-12-18 | 2013-04-18 | 空間構象改變的重組干擾素的晶體、其三維結構及應用 |
Country Status (12)
Country | Link |
---|---|
US (3) | US8846025B2 (zh) |
EP (1) | EP2514761B1 (zh) |
JP (2) | JP2013514279A (zh) |
KR (1) | KR20120108985A (zh) |
CN (2) | CN102101886A (zh) |
AU (1) | AU2010333574B2 (zh) |
CA (1) | CA2784624C (zh) |
ES (1) | ES2631028T3 (zh) |
HK (1) | HK1177749A1 (zh) |
MY (1) | MY169650A (zh) |
SG (1) | SG181785A1 (zh) |
WO (1) | WO2011072487A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102101886A (zh) | 2009-12-18 | 2011-06-22 | 四川辉阳生命工程股份有限公司 | 构象改变的重组干扰素晶体、其三维结构及应用 |
TWI726291B (zh) | 2013-01-07 | 2021-05-01 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
US9830422B1 (en) * | 2013-07-22 | 2017-11-28 | The Curators Of The University Of Missouri | In silico biological and pharmaceutical modeling |
WO2015103643A2 (en) | 2014-01-06 | 2015-07-09 | The General Hospital Corporation | Integrin antagonists |
AU2016260845B2 (en) * | 2015-05-12 | 2021-01-28 | Superlab Far East Limited | Methods of determining interferon having direct inhibitory effects on tumors and uses thereof |
US11562806B2 (en) * | 2018-05-09 | 2023-01-24 | Shenzhen Jingtai Technology Co., Ltd. | Drug crystal structure landscape analysis system and landscape analysis method thereof |
CN111508568B (zh) * | 2020-04-20 | 2023-08-29 | 腾讯科技(深圳)有限公司 | 分子生成方法、装置及计算机可读存储介质和终端设备 |
CN113223631B (zh) * | 2021-05-06 | 2024-05-24 | 吉林大学 | 一种晶体结构解析方法及系统 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4672108A (en) | 1981-12-07 | 1987-06-09 | Hoffmann-La Roche Inc. | Crystalline human leukocyte interferon |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
US5441734A (en) | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
JP2758154B2 (ja) | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
US5480640A (en) | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
US5972331A (en) | 1995-12-22 | 1999-10-26 | Schering Corporation | Crystalline interferon alpha for pulmonary delivery and method for producing the same |
WO1999045389A2 (en) | 1998-03-06 | 1999-09-10 | Abbott Lab | Ligand screening and design by x-ray crystallography |
CN1062565C (zh) | 1998-06-29 | 2001-02-28 | 深圳九先生物工程有限公司 | 重组人α型复合干扰素及其制备方法和用途 |
US6833256B1 (en) * | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
EP2292652A2 (en) | 2000-11-03 | 2011-03-09 | Pestka Biomedical Laboratories, Inc. | Interferons uses and compositions related thereto |
WO2002044197A2 (en) * | 2000-12-01 | 2002-06-06 | Fish Eleanor N | Cytokine receptor binding peptides |
CN1245215C (zh) * | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
US20060035327A1 (en) | 2001-02-28 | 2006-02-16 | Guangwen Wei | Recombinant super-compound interferon and uses thereof |
FR2823764B1 (fr) * | 2001-04-24 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides du gene ifn alpha-17 |
SI2325202T1 (sl) | 2003-08-28 | 2015-02-27 | Superlab Far East Limited | Uporabe interferonov s spremenjeno prostorsko strukturo |
US7585647B2 (en) * | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
CN1910195A (zh) * | 2003-08-28 | 2007-02-07 | 辉阳科技美国公司 | 通过空间构象调节蛋白质功能 |
KR20060130009A (ko) * | 2003-08-28 | 2006-12-18 | 휴이양테크 (유에스에이), 인크. | 변경된 공간 구조를 갖는 인터페론의 용도 |
WO2005067963A1 (en) | 2003-12-23 | 2005-07-28 | Intermune, Inc. | Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens |
CN1740197B (zh) * | 2004-08-26 | 2010-05-12 | 辉阳科技美国公司 | 具有全新空间构象且功效增强的重组干扰素、其制备方法及应用 |
JP2006083126A (ja) * | 2004-09-17 | 2006-03-30 | Institute Of Physical & Chemical Research | タンパク質の結晶化試薬キット及び試薬キットを利用した結晶化スクリーニング方法 |
CA2597317C (en) * | 2005-03-09 | 2018-01-02 | Guangwen Wei | Uses of recombinant super-compound interferons |
CN1710197B (zh) * | 2005-06-17 | 2011-06-22 | 徐州师范大学 | 可变色彩色纤维防伪纸 |
JP4744979B2 (ja) * | 2005-08-24 | 2011-08-10 | 独立行政法人理化学研究所 | ゼオライトを用いたタンパク質結晶化方法 |
JP2008050225A (ja) * | 2006-08-25 | 2008-03-06 | National Institute Of Advanced Industrial & Technology | たんぱく質の合理的な結晶化条件探索法 |
CN102101886A (zh) | 2009-12-18 | 2011-06-22 | 四川辉阳生命工程股份有限公司 | 构象改变的重组干扰素晶体、其三维结构及应用 |
US20130184437A9 (en) | 2011-06-08 | 2013-07-18 | Guangwen Wei | Design and use of new recombinant interferons with altered spatial configuration and three-dimensional structure |
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2009
- 2009-12-18 CN CN2009102593392A patent/CN102101886A/zh active Pending
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2010
- 2010-12-16 EP EP10836926.5A patent/EP2514761B1/en active Active
- 2010-12-16 CA CA2784624A patent/CA2784624C/en active Active
- 2010-12-16 MY MYPI2012002756A patent/MY169650A/en unknown
- 2010-12-16 US US13/516,947 patent/US8846025B2/en active Active
- 2010-12-16 ES ES10836926.5T patent/ES2631028T3/es active Active
- 2010-12-16 JP JP2012543445A patent/JP2013514279A/ja active Pending
- 2010-12-16 WO PCT/CN2010/002055 patent/WO2011072487A1/zh active Application Filing
- 2010-12-16 AU AU2010333574A patent/AU2010333574B2/en active Active
- 2010-12-16 KR KR1020127017945A patent/KR20120108985A/ko not_active Application Discontinuation
- 2010-12-16 CN CN201080057897.1A patent/CN102770447B/zh active Active
- 2010-12-16 SG SG2012044889A patent/SG181785A1/en unknown
- 2010-12-17 US US12/971,956 patent/US8415151B2/en active Active
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2013
- 2013-04-18 HK HK13104725.9A patent/HK1177749A1/zh unknown
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2014
- 2014-08-15 US US14/461,360 patent/US9273109B2/en active Active
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2016
- 2016-03-23 JP JP2016058155A patent/JP2016128507A/ja active Pending
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CA2784624A1 (en) | 2011-06-23 |
CN102770447B (zh) | 2015-03-11 |
WO2011072487A1 (zh) | 2011-06-23 |
CN102770447A (zh) | 2012-11-07 |
JP2013514279A (ja) | 2013-04-25 |
CA2784624C (en) | 2021-05-04 |
EP2514761A4 (en) | 2013-08-28 |
US9273109B2 (en) | 2016-03-01 |
KR20120108985A (ko) | 2012-10-05 |
US20120308520A1 (en) | 2012-12-06 |
CN102101886A (zh) | 2011-06-22 |
AU2010333574B2 (en) | 2017-03-09 |
JP2016128507A (ja) | 2016-07-14 |
MY169650A (en) | 2019-04-25 |
US8415151B2 (en) | 2013-04-09 |
EP2514761B1 (en) | 2016-11-23 |
EP2514761A1 (en) | 2012-10-24 |
US20140356324A1 (en) | 2014-12-04 |
EP2514761A9 (en) | 2013-02-06 |
ES2631028T3 (es) | 2017-08-25 |
US8846025B2 (en) | 2014-09-30 |
AU2010333574A1 (en) | 2012-07-19 |
US20110158941A1 (en) | 2011-06-30 |
SG181785A1 (en) | 2012-07-30 |
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