HK1177749A1 - 空間構象改變的重組干擾素的晶體、其三維結構及應用 - Google Patents

空間構象改變的重組干擾素的晶體、其三維結構及應用

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Publication number
HK1177749A1
HK1177749A1 HK13104725.9A HK13104725A HK1177749A1 HK 1177749 A1 HK1177749 A1 HK 1177749A1 HK 13104725 A HK13104725 A HK 13104725A HK 1177749 A1 HK1177749 A1 HK 1177749A1
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HK
Hong Kong
Prior art keywords
dimensional structure
spatial configuration
recombinant interferon
altered spatial
crystalline recombinant
Prior art date
Application number
HK13104725.9A
Other languages
English (en)
Inventor
魏光文
王大成
Original Assignee
Sichuan Huiyang Life Science & Technology Corp
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Publication date
Application filed by Sichuan Huiyang Life Science & Technology Corp filed Critical Sichuan Huiyang Life Science & Technology Corp
Publication of HK1177749A1 publication Critical patent/HK1177749A1/zh

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30Drug targeting using structural data; Docking or binding prediction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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HK13104725.9A 2009-12-18 2013-04-18 空間構象改變的重組干擾素的晶體、其三維結構及應用 HK1177749A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2009102593392A CN102101886A (zh) 2009-12-18 2009-12-18 构象改变的重组干扰素晶体、其三维结构及应用
PCT/CN2010/002055 WO2011072487A1 (zh) 2009-12-18 2010-12-16 空间构象改变的重组干扰素的晶体、其三维结构及应用

Publications (1)

Publication Number Publication Date
HK1177749A1 true HK1177749A1 (zh) 2013-08-30

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HK13104725.9A HK1177749A1 (zh) 2009-12-18 2013-04-18 空間構象改變的重組干擾素的晶體、其三維結構及應用

Country Status (12)

Country Link
US (3) US8846025B2 (zh)
EP (1) EP2514761B1 (zh)
JP (2) JP2013514279A (zh)
KR (1) KR20120108985A (zh)
CN (2) CN102101886A (zh)
AU (1) AU2010333574B2 (zh)
CA (1) CA2784624C (zh)
ES (1) ES2631028T3 (zh)
HK (1) HK1177749A1 (zh)
MY (1) MY169650A (zh)
SG (1) SG181785A1 (zh)
WO (1) WO2011072487A1 (zh)

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CN102101886A (zh) 2009-12-18 2011-06-22 四川辉阳生命工程股份有限公司 构象改变的重组干扰素晶体、其三维结构及应用
TWI726291B (zh) 2013-01-07 2021-05-01 英屬維爾京群島商遠東超級實驗室有限公司 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物
US9830422B1 (en) * 2013-07-22 2017-11-28 The Curators Of The University Of Missouri In silico biological and pharmaceutical modeling
WO2015103643A2 (en) 2014-01-06 2015-07-09 The General Hospital Corporation Integrin antagonists
AU2016260845B2 (en) * 2015-05-12 2021-01-28 Superlab Far East Limited Methods of determining interferon having direct inhibitory effects on tumors and uses thereof
US11562806B2 (en) * 2018-05-09 2023-01-24 Shenzhen Jingtai Technology Co., Ltd. Drug crystal structure landscape analysis system and landscape analysis method thereof
CN111508568B (zh) * 2020-04-20 2023-08-29 腾讯科技(深圳)有限公司 分子生成方法、装置及计算机可读存储介质和终端设备
CN113223631B (zh) * 2021-05-06 2024-05-24 吉林大学 一种晶体结构解析方法及系统

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US6833256B1 (en) * 1999-06-22 2004-12-21 University Of Maryland Interferon tau mutants and methods for making them
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CN102101886A (zh) 2009-12-18 2011-06-22 四川辉阳生命工程股份有限公司 构象改变的重组干扰素晶体、其三维结构及应用
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CA2784624A1 (en) 2011-06-23
CN102770447B (zh) 2015-03-11
WO2011072487A1 (zh) 2011-06-23
CN102770447A (zh) 2012-11-07
JP2013514279A (ja) 2013-04-25
CA2784624C (en) 2021-05-04
EP2514761A4 (en) 2013-08-28
US9273109B2 (en) 2016-03-01
KR20120108985A (ko) 2012-10-05
US20120308520A1 (en) 2012-12-06
CN102101886A (zh) 2011-06-22
AU2010333574B2 (en) 2017-03-09
JP2016128507A (ja) 2016-07-14
MY169650A (en) 2019-04-25
US8415151B2 (en) 2013-04-09
EP2514761B1 (en) 2016-11-23
EP2514761A1 (en) 2012-10-24
US20140356324A1 (en) 2014-12-04
EP2514761A9 (en) 2013-02-06
ES2631028T3 (es) 2017-08-25
US8846025B2 (en) 2014-09-30
AU2010333574A1 (en) 2012-07-19
US20110158941A1 (en) 2011-06-30
SG181785A1 (en) 2012-07-30

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