HK1175782A1 - 作為α 烟碱型乙酰膽碱受體配體的雙環化合物 - Google Patents

作為α 烟碱型乙酰膽碱受體配體的雙環化合物

Info

Publication number
HK1175782A1
HK1175782A1 HK13103118.6A HK13103118A HK1175782A1 HK 1175782 A1 HK1175782 A1 HK 1175782A1 HK 13103118 A HK13103118 A HK 13103118A HK 1175782 A1 HK1175782 A1 HK 1175782A1
Authority
HK
Hong Kong
Prior art keywords
acetylcholine receptor
receptor ligands
nicotinic acetylcholine
bicyclic compounds
bicyclic
Prior art date
Application number
HK13103118.6A
Other languages
English (en)
Inventor
羅摩克里希納‧尼羅吉
阿卜杜勒‧拉希德‧穆罕默德
斯里尼瓦斯‧維拉馬拉
斯里尼瓦薩‧拉奥‧拉韋拉
伊什蒂雅克‧艾哈邁德
普拉迪普‧賈亞拉揚
阿尼爾‧卡巴里‧欣德
拉馬‧薩斯特里‧坎布漢普蒂
戈皮納德‧比拉普涅尼
文卡特斯瓦盧‧賈斯蒂
Original Assignee
蘇文生命科學有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 蘇文生命科學有限公司 filed Critical 蘇文生命科學有限公司
Publication of HK1175782A1 publication Critical patent/HK1175782A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK13103118.6A 2009-11-18 2013-03-13 作為α 烟碱型乙酰膽碱受體配體的雙環化合物 HK1175782A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2838CH2009 2009-11-18
PCT/IN2009/000758 WO2011061751A1 (en) 2009-11-18 2009-12-31 BICYCLIC COMPOUNDS AS α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

Publications (1)

Publication Number Publication Date
HK1175782A1 true HK1175782A1 (zh) 2013-07-12

Family

ID=42228992

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13103118.6A HK1175782A1 (zh) 2009-11-18 2013-03-13 作為α 烟碱型乙酰膽碱受體配體的雙環化合物

Country Status (24)

Country Link
US (1) US8735423B2 (zh)
EP (1) EP2513085B1 (zh)
JP (1) JP5536227B2 (zh)
KR (1) KR101376145B1 (zh)
CN (1) CN102741239B (zh)
CA (1) CA2773409C (zh)
CY (1) CY1118361T1 (zh)
DK (1) DK2513085T3 (zh)
EA (1) EA020506B1 (zh)
ES (1) ES2601905T3 (zh)
HK (1) HK1175782A1 (zh)
HR (1) HRP20161461T1 (zh)
HU (1) HUE033352T2 (zh)
IL (1) IL219637A (zh)
LT (1) LT2513085T (zh)
MX (1) MX2012005637A (zh)
NZ (1) NZ600536A (zh)
PL (1) PL2513085T3 (zh)
PT (1) PT2513085T (zh)
RS (1) RS55469B1 (zh)
SI (1) SI2513085T1 (zh)
SM (1) SMT201600444B (zh)
WO (1) WO2011061751A1 (zh)
ZA (1) ZA201203522B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9296710B2 (en) * 2011-06-17 2016-03-29 Eli Lilly And Company Bicyclo (3.1.0) hexane-2, 6-dicarboxylic acid derivatives as mGlu2 receptor agonist
JP6103240B2 (ja) 2013-11-18 2017-03-29 トヨタ紡織株式会社 ピッチ材料の調整方法及び調整装置
US10945771B2 (en) 2017-06-09 2021-03-16 Merck Sharp & Dohme Corp. Azabicyclo[4.1.0]heptane allosteric modulators of the M4 muscarinic acetylcholine receptor
WO2023135528A1 (en) 2022-01-11 2023-07-20 Suven Life Sciences Limited Heteroalicyclic derivatives and their use in the treatment of cns disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337341A (en) * 1976-11-02 1982-06-29 Eli Lilly And Company 4a-Aryl-octahydro-1H-2-pyrindines
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
AU7871498A (en) * 1996-12-20 1998-07-17 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
IL146288A0 (en) * 1999-06-30 2002-07-25 Daiichi Seiyaku Co Vla-4 inhibitor compounds
US20040192673A1 (en) 2001-05-05 2004-09-30 Pascale Gaillard N-aroyl cyclic amine derivatives as orexin receptor antagonists
FR2889187B1 (fr) 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI454262B (zh) 2006-11-02 2014-10-01 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺

Also Published As

Publication number Publication date
EP2513085A1 (en) 2012-10-24
US20130072518A1 (en) 2013-03-21
EP2513085B1 (en) 2016-09-28
ZA201203522B (en) 2013-01-31
EA201290344A1 (ru) 2012-10-30
MX2012005637A (es) 2012-06-13
HRP20161461T1 (hr) 2017-01-27
DK2513085T3 (en) 2016-12-05
RS55469B1 (sr) 2017-04-28
AU2009355487A8 (en) 2012-07-12
CA2773409C (en) 2015-06-16
CN102741239A (zh) 2012-10-17
ES2601905T3 (es) 2017-02-16
NZ600536A (en) 2013-05-31
US8735423B2 (en) 2014-05-27
LT2513085T (lt) 2016-12-27
CA2773409A1 (en) 2011-05-26
JP5536227B2 (ja) 2014-07-02
PL2513085T3 (pl) 2017-09-29
SI2513085T1 (sl) 2017-02-28
EA020506B1 (ru) 2014-11-28
HUE033352T2 (en) 2017-11-28
AU2009355487A1 (en) 2012-05-31
CY1118361T1 (el) 2017-06-28
WO2011061751A1 (en) 2011-05-26
SMT201600444B (it) 2017-01-10
IL219637A (en) 2015-10-29
KR101376145B1 (ko) 2014-03-19
AU2009355487B2 (en) 2013-10-10
KR20120049943A (ko) 2012-05-17
JP2013510901A (ja) 2013-03-28
PT2513085T (pt) 2016-11-14
IL219637A0 (en) 2012-07-31
CN102741239B (zh) 2015-06-24

Similar Documents

Publication Publication Date Title
ZA201007527B (en) Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
HK1197233A1 (zh) 螺－羥吲哚化合物的合成方法
HK1177458A1 (zh) 取代的咪唑並吡啶基-氨基吡啶化合物
HK1154856A1 (en) Morphinan compounds
HK1155170A1 (zh) 吡啶化合物
EP2351743A4 (en) BICYCLIC CONNECTION
IL220299A0 (en) ??4??2 neuronal nicotinic acetylcholine receptor ligands
HK1176606A1 (zh) -吡啶酮化合物
EP2246486A4 (en) DECORATIVE COVER STRUCTURE FOR A CONSTRUCTION MACHINE
ZA201204143B (en) 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
IL218525A0 (en) 1,2-dihydro-2-oxoquinoline compounds as 5-ht4 receptor ligands
HK1149205A1 (en) Methods for inhibiting angiogenesis using egfl8 antagonists
IL200801A0 (en) Pyrimidinyl-piperazines useful as d3/d2 receptor ligands
IL219366A0 (en) Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
ZA201007988B (en) Quinuclidine derivatives as muscarinic m3 receptor antagonists
HK1175782A1 (zh) 作為α 烟碱型乙酰膽碱受體配體的雙環化合物
EP2301922A4 (en) pyridone
ZA201100805B (en) Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
TH106311B (th) สารประกอบควินูคลีดีนในฐานะเป็นลิแกนด์ของตัวรับแอลฟา-7 นิโคทินิค แอเซทิลโคลีน
TH1201002302B (th) สารประกอบไบไซคลิกในฐานะเป็นลิแกนด์ของตัวรับ อัลฟา4 เบตา2 นิโคทินิกแอซีทิลโคลีน
SI2321312T1 (sl) Postopek za pripravo paliperidona