HK1172247A1 - 造血幹細胞在治療腎損傷中的用途 - Google Patents

造血幹細胞在治療腎損傷中的用途

Info

Publication number
HK1172247A1
HK1172247A1 HK12113028.5A HK12113028A HK1172247A1 HK 1172247 A1 HK1172247 A1 HK 1172247A1 HK 12113028 A HK12113028 A HK 12113028A HK 1172247 A1 HK1172247 A1 HK 1172247A1
Authority
HK
Hong Kong
Prior art keywords
treatment
stem cells
hematopoietic stem
kidney injury
kidney
Prior art date
Application number
HK12113028.5A
Other languages
English (en)
Inventor
David L Amrani
Delara Motlagh
Catherine M Hoff
Amy Cohen
Jeremy Duffield
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of HK1172247A1 publication Critical patent/HK1172247A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK12113028.5A 2009-10-02 2012-12-18 造血幹細胞在治療腎損傷中的用途 HK1172247A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24831609P 2009-10-02 2009-10-02
PCT/US2010/050812 WO2011041478A1 (en) 2009-10-02 2010-09-30 Hematopoietic stem cells for use in the treatment of a kidney injury

Publications (1)

Publication Number Publication Date
HK1172247A1 true HK1172247A1 (zh) 2013-04-19

Family

ID=43332272

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12113028.5A HK1172247A1 (zh) 2009-10-02 2012-12-18 造血幹細胞在治療腎損傷中的用途

Country Status (9)

Country Link
US (2) US20110091427A1 (zh)
EP (1) EP2482828B1 (zh)
JP (1) JP2013506681A (zh)
KR (1) KR20120100962A (zh)
CN (1) CN102573860A (zh)
AU (1) AU2010300611B2 (zh)
CA (1) CA2776452A1 (zh)
HK (1) HK1172247A1 (zh)
WO (1) WO2011041478A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013126590A2 (en) 2012-02-21 2013-08-29 Baxter International Inc. Pharmaceutical composition comprising cd34+ cells
US8894603B2 (en) 2012-03-20 2014-11-25 Sight Sciences, Inc. Ocular delivery systems and methods
CN104254602A (zh) * 2012-04-24 2014-12-31 克瑞奥埃斯塔麦诺健康与技术股份有限公司 用于心脏组织保护的干细胞的组合物和方法
US10780143B2 (en) 2012-09-19 2020-09-22 University Of Utah Research Foundation Compositions and methods of use for (pro)renin receptor antagonists
US9573976B2 (en) 2012-09-19 2017-02-21 University Of Utah Research Foundation Antagonist for (pro)renin receptor for the treatment of hypertension and diabetes
US9586995B2 (en) 2012-09-19 2017-03-07 University Of Utah Research Foundation Compositions and methods of use for (pro)renin receptor
WO2016019226A1 (en) * 2014-08-01 2016-02-04 University Of Utah Research Foundation Compositions and methods of use for (pro)renin receptor antagonists
JP6525889B2 (ja) * 2013-01-12 2019-06-05 セスカ セラピューティクス， インコーポレイテッド 自己骨髄由来の幹細胞の迅速な注入
US10662407B2 (en) 2015-01-26 2020-05-26 Industrial Cooperation Foundation Chonbuk National University Method for controlling differentiation of embryonic stem cells into adipocytes or kidney precursor cells by regulating SIRT1 expression
WO2016122166A1 (ko) * 2015-01-26 2016-08-04 전북대학교산학협력단 Sirt1 발현 조절을 통한 배아줄기세포로부터 지방세포 또는 신장전구세포로의 분화 조절 방법
JP6781973B2 (ja) * 2016-01-29 2020-11-11 学校法人東京女子医科大学 腎臓病進行抑制細胞シート組成物、その製造方法、及び、それを用いた腎臓病進行抑制方法
EP4378457A3 (en) 2016-11-21 2024-07-31 Saghmos Therapeutics, Inc. Prevention and/or treatment of contrast-induced acute kidney injury
CN108273063A (zh) * 2016-12-30 2018-07-13 国玺干细胞应用技术股份有限公司 用于治疗急性肾脏损伤的医药组合物
US20180190374A1 (en) * 2017-01-03 2018-07-05 Saghmos Therapeutics, Inc. Methods of improving patient compliance to treat contrast-induced injury
KR102311441B1 (ko) * 2020-05-29 2021-10-13 주식회사 로킷헬스케어 그물막을 이용한 신장 치료용 조성물, 이를 포함하는 신장 치료용 의료 키트, 및 이의 경화물을 포함하는 신장 치료용 필름

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US5532341A (en) 1985-03-28 1996-07-02 Sloan-Kettering Institute For Cancer Research Human pluripotent hematopoietic colony stimulating factor
US7144731B2 (en) 1989-10-16 2006-12-05 Amgen Inc. SCF antibody compositions and methods of using the same
US5423778A (en) * 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
US6933286B2 (en) * 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
DE69221484T2 (de) 1991-04-25 1998-02-19 Univ Brown Res Found Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
US6012450A (en) 1993-01-29 2000-01-11 Aradigm Corporation Intrapulmonary delivery of hematopoietic drug
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
DK0952792T3 (da) * 1994-06-06 2003-12-08 Osiris Therapeutics Inc Biomatrix til vævsregeneration
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5840576A (en) * 1994-07-20 1998-11-24 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
DE69636289T2 (de) * 1995-12-18 2007-05-10 Angiodevice International Gmbh Vernetzten polymerisatmassen und verfahren für ihre verwendung
EP2311471A3 (en) * 1996-04-19 2013-05-15 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
US5824084A (en) 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
US6569147B1 (en) 1996-07-26 2003-05-27 Kensey Nash Corporation Systems and methods of use for delivering beneficial agents for revascularizing stenotic bypass grafts and other occluded blood vessels and for other purposes
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow
SE9700983D0 (sv) 1997-03-18 1997-03-18 Ascendia Ab Stimulering, odling och preservation av pankreas- och andra celler
US6638308B2 (en) 1997-10-10 2003-10-28 John D. Corbitt, Jr. Bioabsorbable breast implant
US7031775B2 (en) 1997-11-07 2006-04-18 Medtronic, Inc. Method and system for myocardial infarction repair
US6368612B1 (en) * 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US6232287B1 (en) * 1998-03-13 2001-05-15 The Burnham Institute Molecules that home to various selected organs or tissues
US6514522B2 (en) * 1998-04-08 2003-02-04 Chondros, Inc. Polymer constructs
US6886568B2 (en) 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6352555B1 (en) * 1998-07-10 2002-03-05 The Brigham And Womens Hospital, Inc. Methods for implanting cells
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6884427B1 (en) 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US7097832B1 (en) * 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
WO2000063268A1 (en) * 1999-04-16 2000-10-26 Wm. Marsh Rice University Poly(propylene fumarate) cross linked with poly(ethylene glycol)
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
US6551338B1 (en) * 1999-09-01 2003-04-22 Mcgill University Method and device for myogenesis and angiogenesis of the heart
US6599274B1 (en) 2000-01-20 2003-07-29 John Kucharczyk Cell delivery catheter and method
WO2001055212A2 (en) * 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US7011828B2 (en) * 2000-03-14 2006-03-14 Es Cell International Pte. Ltd. Implanting neural progenitor cells derived for human embryonic stem cells
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
WO2002000171A2 (en) 2000-06-26 2002-01-03 Rxkinetix, Inc. Composition for delivery of hematopoietic growth factor
WO2002018546A2 (en) * 2000-09-01 2002-03-07 Virginia Commonwealth University Intellectual Property Foundation Plasma-derived-fibrin-based matrices and tissue
US6534052B1 (en) * 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
US6736799B1 (en) 2000-10-24 2004-05-18 Vita Licensing, Inc. Delivery device for biological composites and method of preparation thereof
US6852534B2 (en) 2000-11-03 2005-02-08 Kourion Therapeutics Gmbh Method to determine an engrafting cell dose of hematopoietic stem cell transplant units
WO2002043477A1 (en) 2000-12-01 2002-06-06 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6659950B2 (en) 2001-03-02 2003-12-09 Syde Taheri Percutaneous epicardial injection
US6719795B1 (en) 2001-04-25 2004-04-13 Macropore Biosurgery, Inc. Resorbable posterior spinal fusion system
US6607501B2 (en) * 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
US6648849B2 (en) * 2001-06-27 2003-11-18 Ethicon, Inc. Medicinal implant and device and method for loading and delivering implants containing drugs and cells
US6790455B2 (en) 2001-09-14 2004-09-14 The Research Foundation At State University Of New York Cell delivery system comprising a fibrous matrix and cells
US6805860B1 (en) 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
US7452532B2 (en) * 2001-09-30 2008-11-18 Scicotec Gmbh Transluminal application of adult stem cells for body organ tissue repair
CA2465476A1 (en) * 2001-11-08 2003-05-15 The Regents Of The University Of California Methods and compositions for correction of cardiac conduction disturbances
US6758828B2 (en) * 2001-12-10 2004-07-06 Regents Of The University Of Minnesota Catheter for cell delivery in tissue
US6949590B2 (en) * 2002-01-10 2005-09-27 University Of Washington Hydrogels formed by non-covalent linkages
US7033345B2 (en) * 2002-05-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Deflectable microimplant delivery system
US7049348B2 (en) 2002-07-06 2006-05-23 Kensey Nash Corporation Resorbable structure for treating and healing of tissue defects
US7097833B2 (en) 2002-07-19 2006-08-29 Boston Scientific Scimed, Inc. Selected cell delivery for heart failure
US7070582B2 (en) * 2002-08-09 2006-07-04 Boston Scientific Scimed, Inc. Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents
US7135172B1 (en) 2002-09-04 2006-11-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Bucky paper as a support membrane in retinal cell transplantation
US6918869B2 (en) * 2002-12-02 2005-07-19 Scimed Life Systems System for administering a combination of therapies to a body lumen
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
DE602004029337D1 (de) * 2003-04-01 2010-11-11 Us Dept Of Veteran S Affaires Auf stammzellen, vorläuferzellen oder targetzellen basierende behandlung von multiorganversagen.
US20050271657A1 (en) * 2004-06-08 2005-12-08 Australian Stem Cell Centre Ltd. Intermittent treatment regime for organ failure
JP2009509540A (ja) * 2005-09-30 2009-03-12 オクラホマ・メディカル・リサーチ・ファウンデーション 幹細胞におけるＴｏｌｌ様受容体の調節

Also Published As

Publication number Publication date
AU2010300611B2 (en) 2015-12-10
JP2013506681A (ja) 2013-02-28
CA2776452A1 (en) 2011-04-07
EP2482828B1 (en) 2014-12-17
WO2011041478A1 (en) 2011-04-07
WO2011041478A8 (en) 2014-10-09
EP2482828A1 (en) 2012-08-08
US20110091427A1 (en) 2011-04-21
AU2010300611A1 (en) 2012-05-03
CN102573860A (zh) 2012-07-11
US20130302290A1 (en) 2013-11-14
AU2010300611A8 (en) 2015-06-18
KR20120100962A (ko) 2012-09-12

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CHRG Changes in the register

Free format text: CORRECTION OF THE NAME OF THE INVENTOR FROM MOTILAGH, DELARA TO MOTLAGH, DELARA

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191003