HK1170504A1 - The stable polyethylene glycol conjugate of interferon alpha, represented by one positional isomer - Google Patents
The stable polyethylene glycol conjugate of interferon alpha, represented by one positional isomerInfo
- Publication number
- HK1170504A1 HK1170504A1 HK12111241.0A HK12111241A HK1170504A1 HK 1170504 A1 HK1170504 A1 HK 1170504A1 HK 12111241 A HK12111241 A HK 12111241A HK 1170504 A1 HK1170504 A1 HK 1170504A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- represented
- polyethylene glycol
- interferon alpha
- positional isomer
- glycol conjugate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010129824/10A RU2447083C1 (en) | 2010-07-20 | 2010-07-20 | NOVEL FUNCTIONALLY ACTIVE, HIGHLY PURE, STABLE CONJUGATE OF INTERFERON α WITH POLYETHYLENE GLYCOL, REPRESENTED BY ONE PEG- NαH-IFN POSITIONAL ISOMER, WITH IMPROVED IMMUNOGENICITY, WITH PROLONGED BIOLOGICAL ACTION, SUITABLE FOR MEDICAL APPLICATION, AND IMMUNOLOGICAL AGENT BASED THEREON |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1170504A1 true HK1170504A1 (en) | 2013-03-01 |
Family
ID=45497062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12111241.0A HK1170504A1 (en) | 2010-07-20 | 2012-11-07 | The stable polyethylene glycol conjugate of interferon alpha, represented by one positional isomer |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR101586372B1 (en) |
| CN (1) | CN102617736B (en) |
| AR (1) | AR087227A1 (en) |
| BR (1) | BRPI1101565A2 (en) |
| CO (1) | CO6680611A2 (en) |
| CR (1) | CR20130021A (en) |
| CU (1) | CU24193B1 (en) |
| DO (1) | DOP2013000002A (en) |
| EA (1) | EA020257B1 (en) |
| EC (1) | ECSP13012398A (en) |
| HK (1) | HK1170504A1 (en) |
| MX (1) | MX2011007458A (en) |
| MY (1) | MY168784A (en) |
| NI (1) | NI201300008A (en) |
| PE (1) | PE20131034A1 (en) |
| RU (1) | RU2447083C1 (en) |
| SG (1) | SG187117A1 (en) |
| UA (1) | UA99766C2 (en) |
| UY (1) | UY33525A (en) |
| WO (1) | WO2012011836A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2515913C1 (en) * | 2013-03-22 | 2014-05-20 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | HYBRID PROTEIN HAVING PROLONGED ACTION, BASED ON RECOMBINANT HUMAN INTERFERON ALPHA-2 (VARIANTS), METHOD OF ITS PRODUCTION AND STRAIN OF Saccharomyces cerevisiae FOR IMPLEMENTING THIS METHOD (VERSIONS) |
| EA021643B1 (en) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Monopegylated interferon-alpha of linear structure and a pharmaceutical composition for preparing a medicament having interferon-alpha activity |
| EA021610B1 (en) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Liquid antiviral formulation |
| CN103463623B (en) * | 2013-09-03 | 2015-09-09 | 长春海伯尔生物技术有限责任公司 | A kind of Peg-IFN alpha-2b injection and preparation method thereof |
| RU2554761C1 (en) * | 2014-05-13 | 2015-06-27 | Закрытое акционерное общество "Сибирский центр фармакологии и биотехнологии" | Anti-enteroviral and immunostimulating agent |
| RU2572800C1 (en) * | 2014-09-22 | 2016-01-20 | Закрытое Акционерное Общество "Биокад" | New formulation containing polyethylene glycol (peg) conjugated interferon alpha-2beta characterised by less painful administration |
| EA029498B1 (en) * | 2015-11-24 | 2018-04-30 | Учреждение Белорусского государственного университета "Научно-исследовательский институт физико-химических проблем" (НИИ ФХП БГУ) | ANTI-TUMOUR DRUG BASED ON RECOMBINANT INTERFERON ALPHA-2b IN THE FORM OF MICROPARTICLES FOR PARENTERAL ADMINISTRATION |
| RU2678332C1 (en) | 2017-09-08 | 2019-01-28 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") | Pegylated interferon lambda with high bioaccessability in oral use and method for production thereof |
| AU2021258734A1 (en) * | 2020-04-20 | 2023-01-05 | Altum Pharmaceuticals Inc. | Recombinant interferon |
| CN114392237B (en) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | Freeze-dried virus preparation and preparation method thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| JP2758154B2 (en) * | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | Liquid preparations containing interferon |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| RS20050202A (en) * | 2002-09-09 | 2007-08-03 | Nektar Therapeuticals Al.Corporation, | Water-soluble polymer alkanals |
| RU2311930C2 (en) * | 2004-04-30 | 2007-12-10 | Закрытое акционерное общество "ВЕРОФАРМ" | Pagylated interferon against viral infection |
| CA2572751A1 (en) * | 2004-06-30 | 2006-01-12 | Egen Corporation | Pegylated interferon alpha-1b |
| US7872082B2 (en) * | 2005-07-19 | 2011-01-18 | Nektar Therapeutics | Method for preparing polymer maleimides |
| JP2009541333A (en) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | Modified ribonuclease |
| CN101491682A (en) * | 2008-04-30 | 2009-07-29 | 北京凯正生物工程发展有限责任公司 | PEG-IFN omega conjugate and preparation technique thereof |
| CN101591387A (en) * | 2008-05-28 | 2009-12-02 | 中国人民解放军军事医学科学院微生物流行病研究所 | PEG-IFN omega conjugate |
| CN101514229B (en) * | 2009-04-03 | 2012-05-09 | 海南四环心脑血管药物研究院有限公司 | Human interferon alpha derivative and polyethylene glycol modified substance thereof |
-
2010
- 2010-07-20 RU RU2010129824/10A patent/RU2447083C1/en active
- 2010-09-24 MY MYPI2013000216A patent/MY168784A/en unknown
- 2010-09-24 WO PCT/RU2010/000529 patent/WO2012011836A1/en active Application Filing
- 2010-09-24 SG SG2013003801A patent/SG187117A1/en unknown
- 2010-09-24 KR KR1020137001858A patent/KR101586372B1/en not_active IP Right Cessation
- 2010-09-24 PE PE2013000084A patent/PE20131034A1/en not_active Application Discontinuation
- 2010-09-24 CU CUP2013000013A patent/CU24193B1/en active IP Right Grant
- 2010-12-15 UA UAA201015114A patent/UA99766C2/en unknown
-
2011
- 2011-04-01 BR BRPI1101565-9A patent/BRPI1101565A2/en not_active IP Right Cessation
- 2011-06-21 EA EA201100809A patent/EA020257B1/en not_active IP Right Cessation
- 2011-07-12 MX MX2011007458A patent/MX2011007458A/en active IP Right Grant
- 2011-07-19 CN CN201110214149.6A patent/CN102617736B/en not_active Expired - Fee Related
- 2011-07-19 AR ARP110102606A patent/AR087227A1/en unknown
- 2011-07-20 UY UY0001033525A patent/UY33525A/en unknown
-
2012
- 2012-11-07 HK HK12111241.0A patent/HK1170504A1/en not_active IP Right Cessation
-
2013
- 2013-01-04 DO DO2013000002A patent/DOP2013000002A/en unknown
- 2013-01-18 EC ECSP13012398 patent/ECSP13012398A/en unknown
- 2013-01-18 CO CO13009157A patent/CO6680611A2/en unknown
- 2013-01-18 CR CR20130021A patent/CR20130021A/en unknown
- 2013-01-18 NI NI201300008A patent/NI201300008A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CU20130013A7 (en) | 2013-04-19 |
| EA020257B1 (en) | 2014-09-30 |
| KR101586372B1 (en) | 2016-01-18 |
| MX2011007458A (en) | 2012-01-19 |
| KR20130056885A (en) | 2013-05-30 |
| BRPI1101565A2 (en) | 2012-12-04 |
| ECSP13012398A (en) | 2013-05-31 |
| SG187117A1 (en) | 2013-02-28 |
| CN102617736B (en) | 2015-11-25 |
| CN102617736A (en) | 2012-08-01 |
| CR20130021A (en) | 2013-02-20 |
| WO2012011836A1 (en) | 2012-01-26 |
| RU2010129824A (en) | 2012-01-27 |
| DOP2013000002A (en) | 2013-09-15 |
| PE20131034A1 (en) | 2013-09-27 |
| AR087227A1 (en) | 2014-03-12 |
| CO6680611A2 (en) | 2013-05-31 |
| NI201300008A (en) | 2014-05-26 |
| UY33525A (en) | 2012-02-29 |
| CU24193B1 (en) | 2016-09-30 |
| MY168784A (en) | 2018-12-04 |
| RU2447083C1 (en) | 2012-04-10 |
| UA99766C2 (en) | 2012-09-25 |
| EA201100809A1 (en) | 2012-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200717 |