HK1166794A1 - Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitor - Google Patents
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitorInfo
- Publication number
- HK1166794A1 HK1166794A1 HK12107498.8A HK12107498A HK1166794A1 HK 1166794 A1 HK1166794 A1 HK 1166794A1 HK 12107498 A HK12107498 A HK 12107498A HK 1166794 A1 HK1166794 A1 HK 1166794A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- heteroaromatic
- lipase inhibitor
- monoacylglycerol lipase
- amides
- aromatic
- Prior art date
Links
- 229940122357 Monoacylglycerol lipase inhibitor Drugs 0.000 title 1
- -1 aromatic piperazinyl azetidinyl amides Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17166009P | 2009-04-22 | 2009-04-22 | |
| PCT/US2010/032098 WO2010124121A1 (en) | 2009-04-22 | 2010-04-22 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1166794A1 true HK1166794A1 (en) | 2012-11-09 |
Family
ID=42224827
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12107498.8A HK1166794A1 (en) | 2009-04-22 | 2012-07-31 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitor |
| HK12111003.8A HK1170239A1 (en) | 2009-04-22 | 2012-11-01 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12111003.8A HK1170239A1 (en) | 2009-04-22 | 2012-11-01 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8815839B2 (ru) |
| EP (1) | EP2421852B9 (ru) |
| JP (1) | JP2012524809A (ru) |
| KR (1) | KR20120014154A (ru) |
| CN (1) | CN102548983B (ru) |
| AR (1) | AR076375A1 (ru) |
| AU (1) | AU2010238745A1 (ru) |
| BR (1) | BRPI1014888A2 (ru) |
| CA (1) | CA2759714A1 (ru) |
| DK (1) | DK2421852T3 (ru) |
| ES (1) | ES2486674T3 (ru) |
| HK (2) | HK1166794A1 (ru) |
| IL (1) | IL215796A (ru) |
| PT (1) | PT2421852E (ru) |
| RU (1) | RU2558141C2 (ru) |
| TW (1) | TWI495637B (ru) |
| WO (1) | WO2010124121A1 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012524807A (ja) | 2009-04-22 | 2012-10-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | モノアシルグリセロールリパーゼ阻害剤としてのアゼチジニルジアミド |
| CN103068798A (zh) * | 2010-09-03 | 2013-04-24 | 詹森药业有限公司 | 作为单酰甘油脂肪酶抑制剂的二-氮杂环丁烷二酰胺 |
| EP2621918A1 (en) * | 2010-09-27 | 2013-08-07 | Janssen Pharmaceutica, N.V. | Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors |
| US8513423B2 (en) | 2010-10-22 | 2013-08-20 | Janssen Pharmaceutica, Nv | Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors |
| WO2012054721A1 (en) | 2010-10-22 | 2012-04-26 | Janssen Pharmaceutical Nv | Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors |
| US9624170B2 (en) | 2013-12-26 | 2017-04-18 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors |
| AU2015264336B2 (en) | 2014-05-19 | 2018-08-30 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds |
| US10106556B2 (en) | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3331536A4 (en) * | 2015-08-03 | 2019-03-27 | The Regents of The University of California | COMPOSITIONS AND METHODS FOR MODULATING ABHD2 ACTIVITY |
| US10463753B2 (en) | 2016-02-19 | 2019-11-05 | Lundbeck La Jolla Research Center, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
| CA3019298C (en) | 2016-03-31 | 2023-08-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2017170830A1 (ja) | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3689879A4 (en) | 2017-09-29 | 2021-07-14 | Takeda Pharmaceutical Company Limited | HETEROCYCLIC CONNECTION |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| ES2282731T3 (es) * | 2002-12-23 | 2007-10-16 | Janssen Pharmaceutica N.V. | Derivados de 1-piperidin-4-il-4-azetidin-3-il-piperazina sustituida y su uso como antagonistas de neuroquininas. |
| EP1702916A1 (en) * | 2005-03-18 | 2006-09-20 | Santhera Pharmaceuticals (Schweiz) GmbH | DPP-IV inhibitors |
| FR2915199B1 (fr) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique. |
| WO2009132260A1 (en) * | 2008-04-25 | 2009-10-29 | Janssen Pharmaceutica Nv | Protein engineering of monoacylglycerol lipase (mgll) |
| JP5715945B2 (ja) * | 2008-04-25 | 2015-05-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | モノアシルグリセロールリパーゼ（ｍｇｌｌ）の結晶構造 |
| EP2180048B1 (en) * | 2008-10-09 | 2014-12-17 | Janssen Pharmaceutica N.V. | Alternative crystal form of monoacylglycerol lipase (MGLL) |
| US8435977B2 (en) * | 2009-04-22 | 2013-05-07 | Janssen Pharmaceutica, Nv | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
-
2010
- 2010-04-22 RU RU2011147203/04A patent/RU2558141C2/ru not_active IP Right Cessation
- 2010-04-22 AR ARP100101336A patent/AR076375A1/es not_active Application Discontinuation
- 2010-04-22 ES ES10719479.7T patent/ES2486674T3/es active Active
- 2010-04-22 PT PT107194797T patent/PT2421852E/pt unknown
- 2010-04-22 AU AU2010238745A patent/AU2010238745A1/en not_active Abandoned
- 2010-04-22 KR KR1020117027425A patent/KR20120014154A/ko not_active Application Discontinuation
- 2010-04-22 CN CN201080028748.2A patent/CN102548983B/zh not_active Expired - Fee Related
- 2010-04-22 DK DK10719479.7T patent/DK2421852T3/da active
- 2010-04-22 TW TW099112744A patent/TWI495637B/zh not_active IP Right Cessation
- 2010-04-22 CA CA2759714A patent/CA2759714A1/en not_active Abandoned
- 2010-04-22 WO PCT/US2010/032098 patent/WO2010124121A1/en active Application Filing
- 2010-04-22 JP JP2012507394A patent/JP2012524809A/ja active Pending
- 2010-04-22 BR BRPI1014888A patent/BRPI1014888A2/pt not_active IP Right Cessation
- 2010-04-22 EP EP10719479.7A patent/EP2421852B9/en active Active
-
2011
- 2011-10-23 IL IL215796A patent/IL215796A/en not_active IP Right Cessation
-
2012
- 2012-07-31 HK HK12107498.8A patent/HK1166794A1/xx not_active IP Right Cessation
- 2012-11-01 HK HK12111003.8A patent/HK1170239A1/xx not_active IP Right Cessation
-
2013
- 2013-03-04 US US13/784,036 patent/US8815839B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2421852A1 (en) | 2012-02-29 |
| DK2421852T3 (da) | 2014-08-18 |
| RU2011147203A (ru) | 2013-05-27 |
| RU2558141C2 (ru) | 2015-07-27 |
| AU2010238745A1 (en) | 2011-11-10 |
| CA2759714A1 (en) | 2010-10-28 |
| CN102548983B (zh) | 2014-09-17 |
| AR076375A1 (es) | 2011-06-08 |
| EP2421852B9 (en) | 2015-07-01 |
| IL215796A0 (en) | 2012-01-31 |
| IL215796A (en) | 2015-04-30 |
| BRPI1014888A2 (pt) | 2019-09-24 |
| US20130184251A1 (en) | 2013-07-18 |
| ES2486674T3 (es) | 2014-08-19 |
| JP2012524809A (ja) | 2012-10-18 |
| US8815839B2 (en) | 2014-08-26 |
| WO2010124121A1 (en) | 2010-10-28 |
| WO2010124121A8 (en) | 2012-03-08 |
| EP2421852B1 (en) | 2014-05-21 |
| TW201103917A (en) | 2011-02-01 |
| HK1170239A1 (en) | 2013-02-22 |
| TWI495637B (zh) | 2015-08-11 |
| PT2421852E (pt) | 2014-07-31 |
| CN102548983A (zh) | 2012-07-04 |
| KR20120014154A (ko) | 2012-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1166794A1 (en) | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitor | |
| IL215797A0 (en) | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors | |
| HK1170228A1 (en) | Azetidinyl diamides as monoacylglycerol lipase inhibitors | |
| IL225769A0 (en) | Piperidine-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors | |
| EP2456757A4 (en) | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | |
| HK1192879A1 (zh) | 取代的 -苄基環烷基羧酸及其用途 | |
| ZA201204700B (en) | Optimized endonucleases and uses thereof | |
| HK1189587A1 (en) | Bromodomain inhibitors and uses thereof | |
| EP2508600A4 (en) | MUTANT ENZYME AND ITS APPLICATION | |
| IL225815A0 (en) | Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors | |
| SG10201500041XA (en) | Superhydrophilic and water-capturing surfaces | |
| PL2192907T3 (pl) | Kompozycje erytropoetyny i fibronektyny do zastosowań terapeutycznych | |
| GB0921001D0 (en) | Products and uses | |
| IL215835A (en) | Carboxamide compounds and their use as a drug | |
| IL214720A0 (en) | Pyridocarbazole type compounds and applications thereof | |
| IL201254A0 (en) | 5 - oxo - isoxazoles as inhibitors of lipases and phospholipases | |
| AP3650A (en) | Apolipoprotein l-i variants and their use | |
| EP2445895A4 (en) | DITHIOCTATE OF PIPERAZINE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | |
| GB201012950D0 (en) | Stabiliser and assembly | |
| PL2491021T3 (pl) | Nowe acylopiperazynony i ich zastosowanie jako środki farmaceutyczne | |
| EP2427766A4 (en) | HUMAN GENE FG01 AND ITS APPLICATIONS | |
| IL214333A0 (en) | Carbamoylphosphonates as inhibitors and uses thereof | |
| PL388613A1 (pl) | Nowa 7-O-n-pentylo-5-O-metylo-8-prenylonaringenina oraz sposób jej otrzymywania | |
| ZA201003753B (en) | Combustible composition and product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180422 |