HK1160835A1 - Nitric oxide donating prostamides - Google Patents

Nitric oxide donating prostamides

Info

Publication number
HK1160835A1
HK1160835A1 HK11113302.3A HK11113302A HK1160835A1 HK 1160835 A1 HK1160835 A1 HK 1160835A1 HK 11113302 A HK11113302 A HK 11113302A HK 1160835 A1 HK1160835 A1 HK 1160835A1
Authority
HK
Hong Kong
Prior art keywords
prostamides
nitric oxide
oxide donating
donating
nitric
Prior art date
Application number
HK11113302.3A
Other languages
English (en)
Chinese (zh)
Inventor
Francesca Benedini
Stefano Biondi
Valerio Chiroli
Wesley Kwan Mung Chong
Liming Dong
Achim Hans-Pter Krauss
Fabio Nicoli
Ganesh Prasanna
William Francois Vernier
Yi Yang
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of HK1160835A1 publication Critical patent/HK1160835A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK11113302.3A 2008-05-09 2011-12-08 Nitric oxide donating prostamides HK1160835A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5208408P 2008-05-09 2008-05-09
US13933308P 2008-12-19 2008-12-19
PCT/IB2009/005594 WO2009136281A1 (en) 2008-05-09 2009-05-11 Nitric oxide donating prostamides

Publications (1)

Publication Number Publication Date
HK1160835A1 true HK1160835A1 (en) 2012-08-17

Family

ID=41020929

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113302.3A HK1160835A1 (en) 2008-05-09 2011-12-08 Nitric oxide donating prostamides

Country Status (9)

Country Link
US (1) US8101658B2 (ru)
EP (1) EP2274279B1 (ru)
JP (1) JP5401540B2 (ru)
CN (1) CN102099330B (ru)
AR (1) AR076731A1 (ru)
CA (1) CA2723704C (ru)
ES (1) ES2428387T3 (ru)
HK (1) HK1160835A1 (ru)
WO (1) WO2009136281A1 (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011005505A2 (en) * 2009-06-22 2011-01-13 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
AU2012217922B2 (en) 2011-02-14 2017-05-04 Allergan, Inc. Ester derivatives of bimatoprost compositions and methods
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
WO2017042636A1 (en) 2015-09-09 2017-03-16 Advanced Inhalation Therapies (Ait) Ltd. Nitric oxide inhalation therapy for infants with bronchiolitis
CA3043000A1 (en) 2016-11-08 2018-05-17 Bausch & Lomb Incorporated Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma
HUE052204T2 (hu) * 2018-02-21 2021-04-28 Nicox Sa Eljárás nitrogén-monoxidot leadó prosztaglandin analógok elõállítására
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
PL3593788T3 (pl) * 2018-07-12 2021-05-31 Nicox S.A. Kompozycje oftalmologiczne zawierające prostamid uwalniający tlenek azotowy
EP3772511B1 (en) 2019-08-05 2023-11-08 Nicox S.A. Process for the preparation of a nitric oxide donating prostaglandin analogue
JP2024509051A (ja) 2021-02-03 2024-02-29 ニコックス エス．エー． 一酸化窒素供与プロスタグランジン類似体の調製のための方法
CA3232002A1 (en) 2021-09-20 2023-03-23 Nicox Sa Nitric oxide releasing prostamide as neuroprotective agent
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
EP4303211A1 (en) 2022-07-07 2024-01-10 Nicox S.A. Industrial process for the preparation of hexanoic acid, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenyl ethyl)-2-propen-1-yl ester and high pure product
CN115677549A (zh) * 2022-10-27 2023-02-03 神隆医药（常熟）有限公司 一种贝美前列素手性异构体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US6395787B1 (en) * 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
SI1480949T1 (sl) * 2002-03-01 2015-09-30 Allergan, Inc. Priprava prostamidov
GEP20094780B (en) * 2004-01-05 2009-09-25 Nicox Sa Prostaglandin nitrooxyderivatives
WO2007000641A2 (en) 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
US20070015838A1 (en) * 2005-07-14 2007-01-18 Allergan, Inc. Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure

Also Published As

Publication number Publication date
US8101658B2 (en) 2012-01-24
EP2274279A1 (en) 2011-01-19
ES2428387T3 (es) 2013-11-07
CN102099330B (zh) 2014-04-30
AR076731A1 (es) 2011-07-06
EP2274279B1 (en) 2013-07-31
WO2009136281A1 (en) 2009-11-12
CA2723704C (en) 2017-08-22
CN102099330A (zh) 2011-06-15
US20110092590A1 (en) 2011-04-21
CA2723704A1 (en) 2009-11-12
JP2011519910A (ja) 2011-07-14
JP5401540B2 (ja) 2014-01-29

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