HK1159157A1 - Organ-on-a-chip-device - Google Patents

Organ-on-a-chip-device

Info

Publication number
HK1159157A1
HK1159157A1 HK11113717.2A HK11113717A HK1159157A1 HK 1159157 A1 HK1159157 A1 HK 1159157A1 HK 11113717 A HK11113717 A HK 11113717A HK 1159157 A1 HK1159157 A1 HK 1159157A1
Authority
HK
Hong Kong
Prior art keywords
organ
chip
Prior art date
Application number
HK11113717.2A
Other languages
English (en)
Chinese (zh)
Inventor
Uwe Marx
Original Assignee
Uwe Marx
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uwe Marx filed Critical Uwe Marx
Publication of HK1159157A1 publication Critical patent/HK1159157A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
HK11113717.2A 2008-06-04 2011-12-20 Organ-on-a-chip-device HK1159157A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5876608P 2008-06-04 2008-06-04
PCT/EP2009/004008 WO2009146911A2 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device

Publications (1)

Publication Number Publication Date
HK1159157A1 true HK1159157A1 (en) 2012-07-27

Family

ID=41398604

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113717.2A HK1159157A1 (en) 2008-06-04 2011-12-20 Organ-on-a-chip-device

Country Status (11)

Country Link
US (2) US20110086382A1 (xx)
EP (3) EP2730645A3 (xx)
JP (1) JP5774477B2 (xx)
CN (1) CN102257124B (xx)
AU (1) AU2009254177B2 (xx)
CA (1) CA2727003C (xx)
DK (1) DK2335370T3 (xx)
HK (1) HK1159157A1 (xx)
RU (1) RU2517046C2 (xx)
SG (1) SG193829A1 (xx)
WO (1) WO2009146911A2 (xx)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2672201T3 (es) 2008-07-16 2018-06-13 Children's Medical Center Corporation Dispositivo de imitación de órganos con microcanales y métodos de uso
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
SG189192A1 (en) * 2010-09-30 2013-05-31 Nat Univ Corp Tokyo Med & Dent Method and device for myocardial cell evaluation and myocardial toxicity inspection
WO2014081840A1 (en) * 2012-11-21 2014-05-30 Vanderbilt University Organ on chip integration and applications of the same
US10023832B2 (en) 2013-07-16 2018-07-17 Vanderbilt University Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
EP2625425A2 (en) 2010-10-07 2013-08-14 Vanderbilt University Peristaltic micropump and related systems and methods
KR101957923B1 (ko) 2011-02-28 2019-03-14 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 배양 시스템
RU2631807C2 (ru) * 2011-06-02 2017-09-26 Президент Энд Феллоуз Ов Харвард Колледж Способы и применение систем культуры ткани ex vivo
US9725687B2 (en) * 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
EP2634251A1 (en) 2012-02-29 2013-09-04 Technische Universität Berlin 3D in vitro bi-phasic cartilage-bone construct
EP2633870B1 (en) * 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom
SG11201406732XA (en) * 2012-04-26 2014-11-27 Tissuse Gmbh Methods for determining and/or monitoring conditions of a three dimensional cell culture system and optical sensor device for conducting said methods
DK2712918T3 (en) 2012-09-28 2015-02-16 Tissuse Gmbh Multi-organ-chip with improved lifetime and homeostasis
US9267938B2 (en) 2013-03-14 2016-02-23 The Trustees Of The Stevens Institute Of Technology Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma
WO2015013332A1 (en) 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
US11119093B2 (en) 2013-12-20 2021-09-14 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
CN103981096B (zh) * 2014-05-27 2015-11-18 东南大学 一种两层细胞培养体系器官芯片及其制备方法
AU2015267148B2 (en) 2014-05-28 2021-07-29 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
GB2546424A (en) 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
EP3188775A4 (en) * 2014-09-03 2018-09-05 NewSouth Innovations Pty Limited Microfluidic devices and fabrication
WO2016054288A1 (en) * 2014-09-30 2016-04-07 Taylor Lansing D A human liver microphysiology platform and self assembly liver acinus model and methods of their use
EP3207123A1 (en) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
RU2584598C1 (ru) * 2015-03-27 2016-05-20 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Микрофлюидный чип для создания клеточных моделей органов млекопитающих
WO2016158233A1 (ja) * 2015-04-03 2016-10-06 国立研究開発法人産業技術総合研究所 細胞培養装置および細胞培養方法
NL2014840B1 (en) 2015-05-21 2017-01-31 Intecrypt B V Microfluidic device for in vitro 3D cell culture experimentation.
RU2592687C1 (ru) * 2015-06-30 2016-07-27 Евгений Александрович Тоневицкий Устройство пневматического управления клапанами микрофлюидной системы
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
CN105170205B (zh) * 2015-09-19 2017-01-25 大连理工大学 一种基于微流控芯片技术构建的仿生芯片
EP3190172A3 (en) * 2016-01-07 2017-08-30 Vanderbilt University Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
RU171690U1 (ru) * 2016-03-24 2017-06-09 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Микрофлюидный чип для создания клеточных моделей органов млекопитающих
KR102378100B1 (ko) * 2016-04-06 2022-03-23 플루이딕 애널리틱스 리미티드 유동 균형의 향상 또는 이와 관련된 향상
RU2612904C1 (ru) * 2016-04-15 2017-03-13 Евгений Александрович Тоневицкий Способ и микрофлюидный чип для культивирования клеток или клеточной модели
WO2017192997A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
US11629319B2 (en) 2016-06-15 2023-04-18 Mimetas, B.V. Cell culture device and methods
AU2017326179B2 (en) 2016-09-13 2022-12-08 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
KR102026329B1 (ko) 2016-11-10 2019-09-27 울산대학교 산학협력단 마이크로유체칩
CA3043708A1 (en) * 2016-11-17 2018-05-24 Cleveland State University Chip platforms for microarray 3d bioprinting
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
RU2671476C2 (ru) * 2016-12-28 2018-10-31 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) Устройство для двухсторонней децеллюляризации сосудистых графтов различного диаметра и способ оптимизации его работы (варианты)
WO2018208332A2 (en) 2017-02-17 2018-11-15 Koniku, Inc. Systems for detection
US11826757B2 (en) * 2017-08-02 2023-11-28 Wake Forest University Health Sciences Niches-on-a-chip
WO2019060680A1 (en) 2017-09-22 2019-03-28 The Regents Of The University Of Colorado, A Body Corporate MICROPHYSIOLOGICAL ORGAN-ON-CHIP SYSTEM
DE102017222261B4 (de) 2017-12-08 2019-08-29 Technische Universität Braunschweig Herstellungsverfahren für Organ-on-a-Chip Systeme
CN108004144B (zh) * 2017-12-18 2021-04-06 清华大学深圳研究生院 一种含管道网络的器官芯片单元
WO2019157464A1 (en) 2018-02-09 2019-08-15 The Regents Of The University Of Colorado, A Body Corporate Bioprinter and methods of manufacturing an organomimetic device
CN110305787A (zh) * 2018-03-27 2019-10-08 华东理工大学 一种体内力学环境模拟装置
US11480560B2 (en) 2018-06-11 2022-10-25 The Regents Of The University Of Colorado, A Body Corporate Delivery of aerosolized respiratory pathogens
CN109576155B (zh) * 2018-12-18 2021-12-07 大连理工大学 通用神经系统芯片
CN110283724B (zh) * 2019-07-09 2022-07-29 汇芯(北京)科技有限公司 一种高通量类器官表型筛查系统和方法
CN111657861B (zh) * 2020-06-04 2022-02-25 浙江大学 基于双光子显微镜技术的溶栓药效评价方法
US20240110137A1 (en) 2021-02-26 2024-04-04 Universidade Do Minho Multiorgan-on-a-chip device with integrated microbiosensors, methods and uses thereof
EP4071234A1 (en) 2021-04-06 2022-10-12 Julius-Maximilians-Universität Würzburg Decive for fabricating a perfusable three-dimensional tissue construct
CN113186162B (zh) * 2021-04-19 2023-08-15 西安交通大学 一种结构仿生的三维活性类脑组织生物芯片
WO2022260653A1 (en) * 2021-06-08 2022-12-15 Hewlett-Packard Development Company, L.P. Interface device for digital microfluidics
TWI769861B (zh) * 2021-06-15 2022-07-01 國立清華大學 三維細胞培養與藥物測試篩選的陣列平台
CN114369532B (zh) * 2021-12-31 2023-10-03 中国科学院苏州纳米技术与纳米仿生研究所 一种模拟滤过泡的微流控细胞培养装置及其应用
WO2023186302A1 (en) 2022-03-30 2023-10-05 Infinite D.O.O. A method for predictive testing of agents to assess triggering and suppressing adverse outcomes and/or diseases
EP4289929A1 (en) * 2022-06-06 2023-12-13 Finnadvance Oy Membrane structure for stimulating and sensing biological materials, and cell culture plate and microfluidic device both using the same
CN115322904B (zh) * 2022-10-12 2023-01-31 成都诺医德医学检验实验室有限公司 一种模拟膀胱结构的类器官培养装置及其应用
CN115671397B (zh) * 2022-11-10 2023-10-13 上海大学 一种多肽和双生长因子梯度分布的含细胞骨软骨支架及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709869B2 (en) * 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6840999B2 (en) * 2000-07-25 2005-01-11 Board Of Regents The University Of Texas System In situ regrowth and purification of crystalline thin films
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
WO2003085379A2 (en) * 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
EP1702052A4 (en) * 2003-12-19 2009-02-18 Univ Waterloo CELL CELL AND METHOD AND APPARATUS FOR CELL CULTURE
US7407799B2 (en) * 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
CA2557549A1 (en) * 2004-02-27 2005-09-09 Board Of Regents, The University Of Texas System System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements
PT1773978E (pt) * 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
JP4812271B2 (ja) * 2004-08-30 2011-11-09 一般社団法人オンチップ・セロミクス・コンソーシアム 心筋拍動細胞を用いた細胞バイオアッセイチップおよびこれを用いるバイオアッセイ
RU45733U1 (ru) * 2004-11-23 2005-05-27 Давыдов Владимир Николаевич Установка для осуществления микробиологических процессов
US7344739B2 (en) * 2004-12-28 2008-03-18 Council Of Scientific And Industrial Research Anti-allergic herbal formulation
DE102006030068A1 (de) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
US7763456B2 (en) * 2006-09-28 2010-07-27 University Of Washington 3D micro-scale engineered tissue model systems
US20100159590A1 (en) * 2006-10-05 2010-06-24 Nanopoint, Inc. Systems and methods for active microfluidic cell handling
CA2720261C (en) * 2008-04-08 2020-09-22 Massachusetts Institute Of Technology Three-dimensional microfluidic platforms and methods of use thereof

Also Published As

Publication number Publication date
CA2727003A1 (en) 2009-12-10
US20140302549A1 (en) 2014-10-09
CN102257124B (zh) 2014-12-03
US20110086382A1 (en) 2011-04-14
RU2010154493A (ru) 2012-07-20
EP2730644A2 (en) 2014-05-14
EP2335370A2 (en) 2011-06-22
EP2730644A3 (en) 2014-10-22
EP2335370B1 (en) 2014-03-19
JP5774477B2 (ja) 2015-09-09
WO2009146911A2 (en) 2009-12-10
CN102257124A (zh) 2011-11-23
RU2517046C2 (ru) 2014-05-27
WO2009146911A3 (en) 2011-09-15
EP2730645A2 (en) 2014-05-14
SG193829A1 (en) 2013-10-30
AU2009254177A1 (en) 2009-12-10
JP2011528653A (ja) 2011-11-24
AU2009254177B2 (en) 2014-09-11
CA2727003C (en) 2018-09-18
EP2730645A3 (en) 2014-10-22
DK2335370T3 (da) 2014-05-26

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