HK1153731A1 - Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)] - Google Patents
Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]Info
- Publication number
- HK1153731A1 HK1153731A1 HK11108635.1A HK11108635A HK1153731A1 HK 1153731 A1 HK1153731 A1 HK 1153731A1 HK 11108635 A HK11108635 A HK 11108635A HK 1153731 A1 HK1153731 A1 HK 1153731A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hydroxybenzoyl
- caprylate
- monosodium
- amino
- polymorphic forms
- Prior art date
Links
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56947604P | 2004-05-06 | 2004-05-06 | |
| US61941804P | 2004-10-15 | 2004-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1153731A1 true HK1153731A1 (en) | 2012-04-05 |
Family
ID=35320672
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK11108635.1A HK1153731A1 (en) | 2004-05-06 | 2011-08-16 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)] |
| HK11108634.2A HK1153730A1 (en) | 2004-05-06 | 2011-08-16 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111870.9A HK1157318A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111869.2A HK1157317A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111873.6A HK1157737A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK11108634.2A HK1153730A1 (en) | 2004-05-06 | 2011-08-16 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111870.9A HK1157318A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111869.2A HK1157317A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
| HK11111873.6A HK1157737A1 (en) | 2004-05-06 | 2011-11-03 | Crystalline polymorphic forms of monosodium n-[8-(2- hydroxybenzoyl)amino]caprylate n-[8-(2-)]- |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US8636996B2 (es) |
| EP (3) | EP3058944B1 (es) |
| JP (1) | JP4903690B2 (es) |
| CN (6) | CN102001962B (es) |
| AU (1) | AU2005240213B8 (es) |
| BR (1) | BRPI0510231A (es) |
| CA (2) | CA2897225C (es) |
| EA (1) | EA013518B1 (es) |
| ES (3) | ES2729825T3 (es) |
| HK (5) | HK1153731A1 (es) |
| IL (1) | IL178677A (es) |
| MX (1) | MXPA06012842A (es) |
| NZ (1) | NZ550890A (es) |
| SG (1) | SG153039A1 (es) |
| WO (1) | WO2005107462A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030271B2 (en) | 2005-07-05 | 2011-10-04 | Emisphere Technologies, Inc. | Compositions and methods for buccal delivery of human growth hormone |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| JP5475443B2 (ja) * | 2006-06-28 | 2014-04-16 | エミスフェアー・テクノロジーズ・インク | 硝酸ガリウム製剤 |
| US9345722B2 (en) * | 2006-07-24 | 2016-05-24 | Emisphere Technologies, Inc. | Pharmaceutical formulations for the treatment of alzheimer's disease |
| CN101506147B (zh) | 2006-09-07 | 2012-03-21 | 霍夫曼-拉罗奇有限公司 | 用于制备snac（n-（8-[2-羟基苯甲酰基]-氨基）辛酸钠）的方法 |
| PL2215047T3 (pl) | 2007-11-02 | 2014-05-30 | Emisphere Tech Inc | Sposób leczenia niedoborów witaminy b12 |
| JP5985985B2 (ja) * | 2009-08-03 | 2016-09-06 | エミスフィアー テクノロジーズ インコーポレイテッドＥｍｉｓｐｈｅｒｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ，Ｉｎｃ． | 胃腸への影響が減少した即効型ナプロキセン組成物 |
| KR20130026429A (ko) * | 2010-02-24 | 2013-03-13 | 에미스페어 테크놀로지스, 인코포레이티드 | 경구 ｂ12 치료요법 |
| DK3326620T3 (da) | 2010-12-16 | 2020-05-25 | Novo Nordisk As | Faste sammensætninger omfattende en glp-1-agonist og et salt af n-(8-(2- hydroxybenzoyl)amino)caprylsyre |
| KR101972836B1 (ko) | 2011-04-12 | 2019-04-29 | 노보 노르디스크 에이/에스 | 이중 아실화된 ｇｌｐ-1 유도체 |
| DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
| HUE062740T2 (hu) | 2012-03-22 | 2023-12-28 | Novo Nordisk As | GLP-1 peptidek készítményei és elõállításuk |
| ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
| WO2014046983A1 (en) | 2012-09-21 | 2014-03-27 | Intensity Therapeutic | Method of treating cancer |
| US10954824B2 (en) | 2016-12-19 | 2021-03-23 | General Electric Company | Systems and methods for controlling drum levels using flow |
| CN111683676B (zh) | 2018-02-02 | 2024-06-18 | 诺和诺德股份有限公司 | 包含glp-1激动剂、n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐和润滑剂的固体组合物 |
| CN111517980B (zh) * | 2020-05-14 | 2021-02-09 | 台州浦凯医药科技有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸一钾晶型化合物、制备方法及用途 |
| EP4159712A4 (en) * | 2020-05-29 | 2023-12-20 | Sciwind Biosciences Co., Ltd. | CRYSTALLINE POLYMORPH OF N-[8-(2-HYDROXYBENZOYL)AMINO]POTASSIUM OCTANOATE, PREPARATION METHOD AND USE THEREOF |
| JP2022094481A (ja) * | 2020-12-15 | 2022-06-27 | 大阪瓦斯株式会社 | ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体 |
| KR20240035495A (ko) | 2021-07-16 | 2024-03-15 | 노보 노르디스크 에이/에스 | 나트륨 n-(8-(2-하이드록시벤조일)아미노)카프릴레이트 다형체 형태 a |
| CN115108936A (zh) * | 2022-07-29 | 2022-09-27 | 成都普康唯新生物科技有限公司 | 无水体系制备8-(2-羟基苯甲酰胺基)辛酸钠无水晶型的方法 |
| CN117466765B (zh) * | 2023-12-27 | 2024-03-15 | 成都道合尔医药技术有限公司 | 8-(2-羟基苯甲酰胺基)辛酸钠及其合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| CN1151836C (zh) * | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
| US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ATE288415T1 (de) * | 1999-04-05 | 2005-02-15 | Emisphere Tech Inc | Dinatrium-salze, monohydrate und ethanol-solvate |
| JP4707931B2 (ja) * | 2000-08-18 | 2011-06-22 | エミスフェアー・テクノロジーズ・インク | 活性剤デリバリー用化合物および組成物 |
| WO2002016309A1 (en) * | 2000-08-18 | 2002-02-28 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AU2002254082B2 (en) * | 2001-03-01 | 2007-05-24 | Emisphere Technologies, Inc. | Compositions for delivering bisphosphonates |
| JP2002332231A (ja) * | 2001-03-06 | 2002-11-22 | Jiro Takada | γ−ＣＥＨＣ送達剤 |
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2005
- 2005-05-06 CA CA2897225A patent/CA2897225C/en not_active Expired - Fee Related
- 2005-05-06 CN CN2010105934921A patent/CN102001962B/zh active Active
- 2005-05-06 US US11/568,753 patent/US8636996B2/en active Active
- 2005-05-06 AU AU2005240213A patent/AU2005240213B8/en not_active Ceased
- 2005-05-06 MX MXPA06012842A patent/MXPA06012842A/es active IP Right Grant
- 2005-05-06 CA CA2563681A patent/CA2563681C/en not_active Expired - Fee Related
- 2005-05-06 CN CN2010105934599A patent/CN102040536B/zh active Active
- 2005-05-06 WO PCT/US2005/016126 patent/WO2005107462A2/en active Application Filing
- 2005-05-06 CN CN2010105935750A patent/CN102040537A/zh active Pending
- 2005-05-06 CN CN2010105934391A patent/CN102040535B/zh active Active
- 2005-05-06 EP EP16161529.9A patent/EP3058944B1/en active Active
- 2005-05-06 JP JP2007511696A patent/JP4903690B2/ja active Active
- 2005-05-06 ES ES05748026T patent/ES2729825T3/es active Active
- 2005-05-06 ES ES16161529T patent/ES2739500T3/es active Active
- 2005-05-06 SG SG200903067-7A patent/SG153039A1/en unknown
- 2005-05-06 CN CN201010593589.2A patent/CN102001963B/zh active Active
- 2005-05-06 NZ NZ550890A patent/NZ550890A/en not_active IP Right Cessation
- 2005-05-06 BR BRPI0510231-6A patent/BRPI0510231A/pt not_active Application Discontinuation
- 2005-05-06 EA EA200602066A patent/EA013518B1/ru unknown
- 2005-05-06 ES ES19180925T patent/ES2879880T3/es active Active
- 2005-05-06 CN CN2010105936039A patent/CN102040538B/zh active Active
- 2005-05-06 EP EP05748026.1A patent/EP1773351B1/en active Active
- 2005-05-06 EP EP19180925.0A patent/EP3572086B1/en active Active
-
2006
- 2006-10-17 IL IL178677A patent/IL178677A/en active IP Right Grant
-
2011
- 2011-08-16 HK HK11108635.1A patent/HK1153731A1/xx not_active IP Right Cessation
- 2011-08-16 HK HK11108634.2A patent/HK1153730A1/xx not_active IP Right Cessation
- 2011-11-03 HK HK11111870.9A patent/HK1157318A1/xx not_active IP Right Cessation
- 2011-11-03 HK HK11111869.2A patent/HK1157317A1/xx not_active IP Right Cessation
- 2011-11-03 HK HK11111873.6A patent/HK1157737A1/xx not_active IP Right Cessation
-
2013
- 2013-12-23 US US14/138,787 patent/US9321719B2/en active Active
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2016
- 2016-02-22 US US15/049,313 patent/US9750710B2/en active Active
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2017
- 2017-08-03 US US15/668,236 patent/US10188621B2/en active Active
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2018
- 2018-12-06 US US16/212,428 patent/US10744105B2/en active Active
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2020
- 2020-07-30 US US16/943,558 patent/US11395809B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230508 |