HK1150839A1 - Compositions and methods of use for therapeutic antibodies - Google Patents

Compositions and methods of use for therapeutic antibodies

Info

Publication number
HK1150839A1
HK1150839A1 HK11104814.3A HK11104814A HK1150839A1 HK 1150839 A1 HK1150839 A1 HK 1150839A1 HK 11104814 A HK11104814 A HK 11104814A HK 1150839 A1 HK1150839 A1 HK 1150839A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
therapeutic antibodies
antibodies
therapeutic
Prior art date
Application number
HK11104814.3A
Other languages
English (en)
Chinese (zh)
Inventor
Christoph Heusser
Julia Neugebauer
Eveline Schaadt
Stefanie Urlinger
Maximilian Woisetschlaeger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41073830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1150839(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1150839A1 publication Critical patent/HK1150839A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK11104814.3A 2008-07-17 2011-05-17 Compositions and methods of use for therapeutic antibodies HK1150839A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08160671 2008-07-17
EP09160326 2009-05-15
PCT/EP2009/059030 WO2010007082A1 (en) 2008-07-17 2009-07-15 Compositions and methods of use for therapeutic antibodies

Publications (1)

Publication Number Publication Date
HK1150839A1 true HK1150839A1 (en) 2012-01-13

Family

ID=41073830

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11104814.3A HK1150839A1 (en) 2008-07-17 2011-05-17 Compositions and methods of use for therapeutic antibodies

Country Status (41)

Country Link
US (3) US8106163B2 (xx)
EP (1) EP2315780B8 (xx)
JP (2) JP5767109B2 (xx)
KR (2) KR101314369B1 (xx)
CN (1) CN102119174B (xx)
AR (1) AR072749A1 (xx)
AU (1) AU2009272771B2 (xx)
BR (1) BRPI0915928B8 (xx)
CA (1) CA2730063C (xx)
CL (1) CL2011000086A1 (xx)
CR (1) CR11863A (xx)
CU (1) CU23878B1 (xx)
CY (1) CY1116800T1 (xx)
DK (1) DK2315780T3 (xx)
DO (1) DOP2011000016A (xx)
EA (1) EA024492B1 (xx)
EC (1) ECSP11010761A (xx)
ES (1) ES2547270T3 (xx)
GE (1) GEP20146129B (xx)
HK (1) HK1150839A1 (xx)
HR (1) HRP20151227T1 (xx)
HU (1) HUE025778T2 (xx)
IL (1) IL210485A (xx)
JO (1) JO3149B1 (xx)
MA (1) MA32481B1 (xx)
MX (1) MX2011000616A (xx)
MY (1) MY158980A (xx)
NI (1) NI201100017A (xx)
NZ (1) NZ590057A (xx)
PE (1) PE20110563A1 (xx)
PL (1) PL2315780T3 (xx)
PT (1) PT2315780E (xx)
RS (1) RS54299B1 (xx)
SG (1) SG193805A1 (xx)
SI (1) SI2315780T1 (xx)
SM (1) SMP201100010B (xx)
SV (1) SV2011003807A (xx)
TW (1) TWI508742B (xx)
UY (1) UY31987A (xx)
WO (1) WO2010007082A1 (xx)
ZA (1) ZA201008952B (xx)

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US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
AU2008287426B2 (en) * 2007-08-10 2014-06-26 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US8680019B2 (en) * 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
EP2648750B1 (en) * 2010-12-10 2017-01-25 Novartis AG Antibody formulation
JP2012153788A (ja) * 2011-01-25 2012-08-16 Nitto Denko Corp 光学用粘着シート
US9216219B2 (en) 2012-06-12 2015-12-22 Novartis Ag Anti-BAFFR antibody formulation
WO2015100246A1 (en) 2013-12-24 2015-07-02 Ossianix, Inc. Baff selective binding compounds and related methods
BR112016014731A2 (pt) 2014-01-31 2017-09-19 Boehringer Ingelheim Int Anticorpos anti-baff
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
BR112017007379A2 (pt) 2014-10-14 2017-12-19 Dana Farber Cancer Inst Inc moléculas de anticorpo para pd-l1 e usos das mesmas
EP3328418A1 (en) 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
PL3317301T3 (pl) 2015-07-29 2021-11-15 Novartis Ag Terapie skojarzone zawierające cząsteczki przeciwciał przeciw lag-3
CN108495651A (zh) 2015-12-17 2018-09-04 诺华股份有限公司 抗pd-1的抗体分子及其用途
RS60477B1 (sr) 2016-02-10 2020-08-31 Novartis Ag Upotreba inhibitora aktivnosti ili funkcije pi3k za lečenje primarnog sjögren-ovog sindroma
JP7275446B2 (ja) * 2016-06-06 2023-05-18 シティ・オブ・ホープ Ｂａｆｆ－ｒ抗体及びその使用
US11197928B2 (en) 2017-01-13 2021-12-14 Board Of Regents, The University Of Texas System Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate
WO2018217918A2 (en) * 2017-05-24 2018-11-29 Als Therapy Development Institute Therapeutic anti-cd40 ligand antibodies
EP3642237A2 (en) * 2017-06-20 2020-04-29 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
KR20210032311A (ko) * 2018-07-20 2021-03-24 테네오바이오, 인코포레이티드 Cd19에 결합하는 중쇄 항체
TW202102540A (zh) * 2019-03-29 2021-01-16 日商中外製藥股份有限公司 包含抗il-6受體抗體之bbb功能低下之抑制劑
EP4055047A1 (en) 2019-11-06 2022-09-14 Novartis AG Treatment for sjögren's syndrome
CN112813099A (zh) * 2019-11-15 2021-05-18 上海细胞治疗集团有限公司 一种在活化的t细胞中具有高活性的启动子
KR20230042377A (ko) 2020-08-04 2023-03-28 노파르티스 아게 Cll 치료
TW202221033A (zh) 2020-08-04 2022-06-01 瑞士商諾華公司 Ｂ細胞惡性腫瘤的治療
CN114149504B (zh) * 2020-09-07 2024-01-12 白先宏 Baff-r结合分子及其应用
IL302412A (en) 2020-11-06 2023-06-01 Novartis Ag Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies
CN115073598B (zh) * 2021-03-15 2024-02-20 盛禾(中国)生物制药有限公司 一种抗baffr抗体及其应用
KR20240004760A (ko) 2021-05-04 2024-01-11 노파르티스 아게 항-baffr 항체를 사용한 루푸스 신염의 치료
JP2024516019A (ja) 2021-05-04 2024-04-11 ノバルティス アーゲー 抗ｂａｆｆｒ抗体を使用する全身性エリテマトーデスのための治療

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MXPA02001665A (es) * 1999-08-17 2003-07-14 Biogen Inc Receptor de baff (bcma) como agente inmunorregulador.
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
EA200701211A1 (ru) 2004-12-31 2007-12-28 Дженентек, Инк. Полипептиды, которые связываются с br3, и их применение
WO2008008482A2 (en) 2006-07-13 2008-01-17 Genentech, Inc. Altered br3-binding polypeptides

Also Published As

Publication number Publication date
GEP20146129B (en) 2014-08-11
HUE025778T2 (en) 2016-05-30
MY158980A (en) 2016-11-30
AU2009272771A1 (en) 2010-01-21
CA2730063A1 (en) 2010-01-21
US9382326B2 (en) 2016-07-05
SV2011003807A (es) 2011-03-23
US9340620B2 (en) 2016-05-17
SI2315780T1 (sl) 2015-11-30
JP2011527896A (ja) 2011-11-10
EA201100191A1 (ru) 2011-08-30
CL2011000086A1 (es) 2011-07-01
CU20110013A7 (es) 2012-06-21
UY31987A (es) 2010-02-26
JP5767109B2 (ja) 2015-08-19
CN102119174B (zh) 2015-01-21
PL2315780T3 (pl) 2016-01-29
EP2315780B8 (en) 2015-09-23
JO3149B1 (ar) 2017-09-20
TWI508742B (zh) 2015-11-21
CN102119174A (zh) 2011-07-06
NZ590057A (en) 2012-08-31
AR072749A1 (es) 2010-09-15
PE20110563A1 (es) 2011-08-29
CR11863A (es) 2011-02-11
SG193805A1 (en) 2013-10-30
ECSP11010761A (es) 2011-02-28
IL210485A (en) 2015-03-31
DOP2011000016A (es) 2011-02-15
BRPI0915928B1 (pt) 2020-10-20
BRPI0915928A2 (pt) 2015-11-03
CY1116800T1 (el) 2017-03-15
ZA201008952B (en) 2012-01-25
ES2547270T3 (es) 2015-10-05
US8106163B2 (en) 2012-01-31
NI201100017A (es) 2012-08-17
KR101545795B1 (ko) 2015-08-19
MA32481B1 (fr) 2011-07-03
KR20130098432A (ko) 2013-09-04
IL210485A0 (en) 2011-03-31
EP2315780A1 (en) 2011-05-04
AU2009272771B2 (en) 2012-09-20
HRP20151227T1 (hr) 2015-12-18
US20100021452A1 (en) 2010-01-28
DK2315780T3 (en) 2015-10-19
SMAP201100010A (it) 2011-05-06
US20120183529A1 (en) 2012-07-19
PT2315780E (pt) 2015-11-30
EP2315780B1 (en) 2015-08-19
CU23878B1 (es) 2013-04-19
WO2010007082A1 (en) 2010-01-21
SMP201100010B (it) 2011-09-09
TW201006493A (en) 2010-02-16
CA2730063C (en) 2017-04-18
JP6077587B2 (ja) 2017-02-08
EA024492B1 (ru) 2016-09-30
US20120195913A1 (en) 2012-08-02
KR20110020914A (ko) 2011-03-03
JP2015133983A (ja) 2015-07-27
RS54299B1 (en) 2016-02-29
BRPI0915928B8 (pt) 2021-05-25
MX2011000616A (es) 2011-02-24
KR101314369B1 (ko) 2013-10-10

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