HK1137426A1 - Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate - Google Patents

Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate

Info

Publication number
HK1137426A1
HK1137426A1 HK10100929.4A HK10100929A HK1137426A1 HK 1137426 A1 HK1137426 A1 HK 1137426A1 HK 10100929 A HK10100929 A HK 10100929A HK 1137426 A1 HK1137426 A1 HK 1137426A1
Authority
HK
Hong Kong
Prior art keywords
positively charged
skin penetration
penetration rate
charged water
soluble prodrugs
Prior art date
Application number
HK10100929.4A
Other languages
English (en)
Chinese (zh)
Inventor
于崇曦
徐麗娜
Original Assignee
于崇曦
上海泰飛爾生化技術有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 于崇曦, 上海泰飛爾生化技術有限公司 filed Critical 于崇曦
Publication of HK1137426A1 publication Critical patent/HK1137426A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10100929.4A 2006-09-03 2010-01-28 Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate HK1137426A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/053090 WO2008029199A1 (fr) 2006-09-03 2006-09-03 Promédicaments hydrosolubles positivement chargés d'acides n-arylanthraniliques à vitesse de pénétration cutanée très élevée

Publications (1)

Publication Number Publication Date
HK1137426A1 true HK1137426A1 (en) 2010-07-30

Family

ID=39156867

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100929.4A HK1137426A1 (en) 2006-09-03 2010-01-28 Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate

Country Status (6)

Country Link
EP (2) EP2084132B1 (fr)
CN (1) CN101506168B (fr)
ES (2) ES2694685T3 (fr)
HK (1) HK1137426A1 (fr)
PL (2) PL2623495T3 (fr)
WO (1) WO2008029199A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CA2665081C (fr) 2006-10-02 2015-12-01 Techfields Biochem Co. Ltd Promedicaments hydrosolubles de prostaglandines et composes analogues, positivement charges, a taux de penetration cutanee tres eleve
EP2091914A4 (fr) 2006-11-08 2010-12-29 Chongxi Yu Systèmes de libération transdermique de peptides et composés associés
CN101547898B (zh) 2006-12-10 2014-09-24 于崇曦 β-内酰胺类抗生素的透皮给药系统
CN101605754B (zh) 2007-01-15 2015-09-16 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的维生素a酸类和类维生素a酸化合物的前药
EP2115140B8 (fr) 2007-01-31 2017-01-25 Chongxi Yu Promédicaments hydrosolubles à charge positive de 1H-imidazo[4,5-c]quinolin-4-amines et composés associés a taux éléves de pénétration cutanée
JP2010529101A (ja) 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
WO2009037705A2 (fr) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Méthodes et compositions utiles pour le traitement du cancer et de l'inflammation
EP2203411B1 (fr) 2007-09-20 2016-01-06 Ramot at Tel-Aviv University Ltd. Dérivés de l'acide n-phénylanthranilique et leurs utilisations
MX362949B (es) * 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.
CN109232716A (zh) 2009-05-08 2019-01-18 上海泰飞尔生化技术有限公司 多肽和多肽相关化合物的高穿透力前药组合物
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US20120022116A1 (en) * 2010-07-20 2012-01-26 Huayun Deng Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
CN107929743B (zh) 2012-01-18 2023-09-01 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
CA2917145C (fr) 2013-03-15 2023-10-24 Techfields Pharma Co., Ltd. Nouveaux medicaments a penetration elevee et leurs compositions pour le traitement de maladies de parkinson
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
US11186596B2 (en) 2018-04-26 2021-11-30 Adt Pharmaceuticals, Llc Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses
WO2020070557A1 (fr) * 2018-10-02 2020-04-09 Q Biomed Inc. Analogues d'agent thérapeutique modifiés d'acide méfénamique
US20220267270A1 (en) * 2019-08-30 2022-08-25 University Of South Florida Sting modulators, compositions, and methods of use

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US2671805A (en) * 1952-07-02 1954-03-09 Searle & Co Basically substituted o-arylamino-benzamides
GB984471A (en) * 1961-01-12 1965-02-24 Parke Davis & Co Anthranilic acid esters and methods for producing the same
BE630053A (fr) * 1962-03-27
US3420871A (en) * 1964-09-01 1969-01-07 Parke Davis & Co Anthranilic acid esters
DK121236B (da) * 1967-07-03 1971-09-27 Gea As Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf.
GB1187259A (en) * 1967-10-23 1970-04-08 Hexachimie New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture
US3814811A (en) * 1972-06-07 1974-06-04 Andreu Sa Dr Method of eliminating or alleviating local pain with diethylaminoethyl flufenamate
JPS57183738A (en) * 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
JPS6452742A (en) * 1987-04-27 1989-02-28 Syntex Pharma Int Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory
US5654337A (en) 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
AUPN531195A0 (en) 1995-09-11 1995-10-05 J.W. Broadbent Nominees Pty. Ltd. Lipid extract having anti-inflamatory activity
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US5885597A (en) 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain
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Also Published As

Publication number Publication date
ES2735287T3 (es) 2019-12-17
PL2084132T3 (pl) 2019-03-29
EP2623495A1 (fr) 2013-08-07
EP2623495B1 (fr) 2019-05-01
WO2008029199A1 (fr) 2008-03-13
EP2084132A4 (fr) 2010-05-26
CN101506168B (zh) 2014-12-10
EP2084132B1 (fr) 2018-08-08
EP2084132A1 (fr) 2009-08-05
ES2694685T3 (es) 2018-12-26
CN101506168A (zh) 2009-08-12
PL2623495T3 (pl) 2019-11-29

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