HK1130191A1 - Factor ix moiety-polymer conjugates having a releaseable linkage - Google Patents
Factor ix moiety-polymer conjugates having a releaseable linkageInfo
- Publication number
- HK1130191A1 HK1130191A1 HK09109161.5A HK09109161A HK1130191A1 HK 1130191 A1 HK1130191 A1 HK 1130191A1 HK 09109161 A HK09109161 A HK 09109161A HK 1130191 A1 HK1130191 A1 HK 1130191A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- moiety
- factor
- polymer conjugates
- releaseable linkage
- releaseable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87758906P | 2006-12-27 | 2006-12-27 | |
PCT/US2007/026425 WO2008082613A2 (fr) | 2006-12-27 | 2007-12-27 | Conjugués polymère-fraction à activité facteur ix comprenant une liaison dégradable |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1130191A1 true HK1130191A1 (en) | 2009-12-24 |
Family
ID=39321802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09109161.5A HK1130191A1 (en) | 2006-12-27 | 2009-10-02 | Factor ix moiety-polymer conjugates having a releaseable linkage |
Country Status (13)
Country | Link |
---|---|
US (1) | US8507653B2 (fr) |
EP (1) | EP2097108B1 (fr) |
JP (1) | JP5606738B2 (fr) |
KR (1) | KR101442867B1 (fr) |
CN (1) | CN101588819B (fr) |
AU (1) | AU2007339238B2 (fr) |
BR (1) | BRPI0720619B1 (fr) |
CA (1) | CA2672021C (fr) |
HK (1) | HK1130191A1 (fr) |
MX (1) | MX2009007146A (fr) |
NO (1) | NO342748B1 (fr) |
NZ (1) | NZ577397A (fr) |
WO (1) | WO2008082613A2 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010014258A2 (fr) * | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugués possédant une liaison libérable |
EP2459227B1 (fr) | 2009-07-31 | 2021-03-17 | Ascendis Pharma A/S | Promédicaments contenant une amine aromatique liée à un support par liaison amide |
US8754190B2 (en) | 2010-05-05 | 2014-06-17 | Prolynx Llc | Controlled release from macromolecular conjugates |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
WO2015034925A1 (fr) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Polynucléotides circulaires |
JP2016530294A (ja) | 2013-09-03 | 2016-09-29 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | キメラポリヌクレオチド |
KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
CA2955250A1 (fr) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Polynucleotides chimeriques |
EP3171895A1 (fr) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Polynucléotides modifiés destinés à la production d'anticorps intracellulaires |
MX2018004296A (es) * | 2015-10-08 | 2018-08-01 | Nektar Therapeutics | Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada. |
EP3625246A1 (fr) | 2017-05-18 | 2020-03-25 | ModernaTX, Inc. | Polynucléotides codant pour des polypeptides d'interleukine-12 (il12) ancrés et leurs utilisations |
US11485972B2 (en) | 2017-05-18 | 2022-11-01 | Modernatx, Inc. | Modified messenger RNA comprising functional RNA elements |
US20200268666A1 (en) | 2017-06-14 | 2020-08-27 | Modernatx, Inc. | Polynucleotides encoding coagulation factor viii |
US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
US11859215B2 (en) | 2017-11-22 | 2024-01-02 | Modernatx, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
JP7423521B2 (ja) | 2017-11-22 | 2024-01-29 | モダーナティエックス・インコーポレイテッド | フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド |
MA50802A (fr) | 2017-11-22 | 2020-09-30 | Modernatx Inc | Polynucléotides codant pour des sous-unités alpha et bêta de propionyl-coa carboxylase pour le traitement de l'acidémie propionique |
EP3735270A1 (fr) | 2018-01-05 | 2020-11-11 | Modernatx, Inc. | Polynucléotides codant pour des anticorps anti-virus du chikungunya |
EP3796893A1 (fr) | 2018-05-23 | 2021-03-31 | Modernatx, Inc. | Administration d'adn |
US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
WO2020047201A1 (fr) | 2018-09-02 | 2020-03-05 | Modernatx, Inc. | Polynucléotides codant pour l'acyl-coa déshydrogénase à très longue chaîne pour le traitement de l'insuffisance en acyl-coa déshydrogénase à très longue chaîne |
WO2020056155A2 (fr) | 2018-09-13 | 2020-03-19 | Modernatx, Inc. | Polynucléotides codant pour les sous-unités e1-alpha, e1-beta et e2 du complexe alpha-cétoacide déshydrogénase à chaîne ramifiée pour le traitement de la leucinose |
CA3112208A1 (fr) | 2018-09-13 | 2020-03-19 | Modernatx, Inc. | Polynucleotides codant la glucose-6-phosphatase pour le traitement de la glycogenose |
JP2022500444A (ja) | 2018-09-14 | 2022-01-04 | モダーナティエックス・インコーポレイテッドModernaTX, Inc. | クリグラー−ナジャー症候群の治療のためのウリジン二リン酸グリコシルトランスフェラーゼ1ファミリー、ポリペプチドa1をコードするポリヌクレオチド |
WO2020069169A1 (fr) | 2018-09-27 | 2020-04-02 | Modernatx, Inc. | Polynucléotides codant pour l'arginase 1 pour le traitement d'une déficience en arginase |
CN114375190A (zh) | 2019-05-08 | 2022-04-19 | 阿斯利康(瑞典)有限公司 | 用于皮肤和伤口的组合物及其使用方法 |
WO2021154414A2 (fr) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Thérapie génique pour l'hémophilie b avec un vecteur de capside d'aav chimérique codant pour des polypeptides du facteur ix modifiés |
US20230235298A1 (en) | 2020-06-01 | 2023-07-27 | Modernatx, Inc. | Phenylalanine hydroxylase variants and uses thereof |
AU2021377895A1 (en) | 2020-11-13 | 2023-06-15 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
US20240207374A1 (en) | 2021-03-24 | 2024-06-27 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof |
WO2022204380A1 (fr) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Nanoparticules lipidiques contenant des polynucléotides codant pour des sous-unités alpha et bêta de propionyl-coa carboxylase et leurs utilisations |
EP4314260A1 (fr) | 2021-03-24 | 2024-02-07 | Modernatx, Inc. | Nanoparticules lipidiques et polynucléotides codant pour l'ornithine transcarbamylase pour le traitement d'une déficience en ornithine transcarbamylase |
US20240207444A1 (en) | 2021-03-24 | 2024-06-27 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof |
WO2022204369A1 (fr) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Polynucléotides codant pour la méthylmalonyl-coa mutase pour le traitement de l'acidémie méthylmalonique |
EP4355882A2 (fr) | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Polynucléotides modifiés pour expression spécifique de type cellulaire ou micro-environnement |
WO2022271776A1 (fr) | 2021-06-22 | 2022-12-29 | Modernatx, Inc. | Polynucléotides codant pour le polypeptide a1, de la famille de l'uridine diphosphate glycosyltransférase 1, pour le traitement du syndrome de crigler-najjar |
WO2023056044A1 (fr) | 2021-10-01 | 2023-04-06 | Modernatx, Inc. | Polynucléotides codant la relaxine pour le traitement de la fibrose et/ou d'une maladie cardiovasculaire |
WO2023183909A2 (fr) | 2022-03-25 | 2023-09-28 | Modernatx, Inc. | Polynucléotides codant pour des protéines du groupe de complémentation de l'anémie de fanconi, destinées au traitement de l'anémie de fanconi |
WO2024026254A1 (fr) | 2022-07-26 | 2024-02-01 | Modernatx, Inc. | Polynucléotides modifiés pour la régulation temporelle de l'expression |
WO2024130158A1 (fr) | 2022-12-16 | 2024-06-20 | Modernatx, Inc. | Nanoparticules lipidiques et polynucléotides codant l'interleukine-22 à demi-vie sérique étendue pour le traitement d'une maladie métabolique |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS58208743A (ja) | 1982-05-28 | 1983-12-05 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
US5298643A (en) | 1992-12-22 | 1994-03-29 | Enzon, Inc. | Aryl imidate activated polyalkylene oxides |
US5349001A (en) * | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5612039A (en) | 1994-03-14 | 1997-03-18 | Nini E. Policappelli | Dietary supplement |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
AU2903899A (en) | 1998-03-12 | 1999-09-27 | Shearwater Polymers Inc. | Poly(ethylene glycol) derivatives with proximal reactive groups |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
KR100432152B1 (ko) | 2001-04-12 | 2004-05-17 | 한국화학연구원 | 다분지형 폴리알킬렌 옥시드 포로젠과 이를 이용한저유전성 절연막 |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
ES2911435T3 (es) * | 2003-02-26 | 2022-05-19 | Nektar Therapeutics | Conjugados de polímero-resto de Factor VIII |
WO2004084949A2 (fr) | 2003-03-20 | 2004-10-07 | Xencor | Production de promedicaments a base de proteines au moyen de liaisons ppg reversibles |
WO2004089279A2 (fr) | 2003-04-08 | 2004-10-21 | Yeda Research And Development Co. Ltd. | Derives d'agonistes pyy a action prolongee |
SI1620118T1 (sl) | 2003-04-08 | 2014-11-28 | Yeda Research And Development Co., Ltd. | Reverzibilna pegilirana zdravila |
WO2005014049A2 (fr) | 2003-08-08 | 2005-02-17 | Novo Nordisk A/S | Synthese et utilisation de nouveaux polymeres ramifies structuraux bien definis comme agents de conjugaison de peptides |
US7579444B2 (en) * | 2004-06-30 | 2009-08-25 | Nektar Therapeutics Al, Corporation | Polymer-factor IX moiety conjugates |
PT2279758E (pt) | 2005-06-16 | 2015-05-27 | Nektar Therapeutics | Conjugados possuindo uma ligação degradável e reagentes poliméricos úteis na preparação de tais conjugados |
AU2006278490A1 (en) | 2005-08-04 | 2007-02-15 | Nektar Therapeutics | Conjugates of a G-CSF moiety and a polymer |
EP2364735A3 (fr) * | 2005-12-16 | 2012-04-11 | Nektar Therapeutics | Conjugé de GLP-1 et de PEG ramafié |
CA2671676C (fr) * | 2006-12-27 | 2014-04-22 | Baxter Healthcare Sa | Conjugues polymere-facteur viii et facteur von willebrand comprenant une liaison degradable |
-
2007
- 2007-12-27 CN CN2007800482799A patent/CN101588819B/zh active Active
- 2007-12-27 JP JP2009544104A patent/JP5606738B2/ja active Active
- 2007-12-27 US US12/006,073 patent/US8507653B2/en active Active
- 2007-12-27 WO PCT/US2007/026425 patent/WO2008082613A2/fr active Application Filing
- 2007-12-27 NZ NZ577397A patent/NZ577397A/en unknown
- 2007-12-27 EP EP07868101.2A patent/EP2097108B1/fr active Active
- 2007-12-27 KR KR1020097013962A patent/KR101442867B1/ko active IP Right Grant
- 2007-12-27 MX MX2009007146A patent/MX2009007146A/es active IP Right Grant
- 2007-12-27 BR BRPI0720619-4A patent/BRPI0720619B1/pt active IP Right Grant
- 2007-12-27 AU AU2007339238A patent/AU2007339238B2/en active Active
- 2007-12-27 CA CA2672021A patent/CA2672021C/fr active Active
-
2009
- 2009-06-08 NO NO20092186A patent/NO342748B1/no unknown
- 2009-10-02 HK HK09109161.5A patent/HK1130191A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101588819B (zh) | 2012-11-21 |
CN101588819A (zh) | 2009-11-25 |
WO2008082613A9 (fr) | 2008-08-21 |
JP2010514770A (ja) | 2010-05-06 |
KR20090102785A (ko) | 2009-09-30 |
NO20092186L (no) | 2009-08-06 |
WO2008082613A3 (fr) | 2009-04-09 |
NZ577397A (en) | 2012-01-12 |
US8507653B2 (en) | 2013-08-13 |
NO342748B1 (no) | 2018-08-06 |
AU2007339238B2 (en) | 2013-06-20 |
CA2672021A1 (fr) | 2008-07-10 |
BRPI0720619A2 (pt) | 2014-03-25 |
BRPI0720619B1 (pt) | 2022-04-05 |
EP2097108B1 (fr) | 2014-02-12 |
WO2008082613A2 (fr) | 2008-07-10 |
MX2009007146A (es) | 2009-07-09 |
CA2672021C (fr) | 2014-02-11 |
AU2007339238A1 (en) | 2008-07-10 |
KR101442867B1 (ko) | 2014-09-25 |
EP2097108A2 (fr) | 2009-09-09 |
JP5606738B2 (ja) | 2014-10-15 |
US20080188414A1 (en) | 2008-08-07 |
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