HK1116660A1 - Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency bmp - Google Patents
Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency bmpInfo
- Publication number
- HK1116660A1 HK1116660A1 HK08105989.4A HK08105989A HK1116660A1 HK 1116660 A1 HK1116660 A1 HK 1116660A1 HK 08105989 A HK08105989 A HK 08105989A HK 1116660 A1 HK1116660 A1 HK 1116660A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bmp
- mediated
- treat
- antagonists
- iron
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65347905P | 2005-02-16 | 2005-02-16 | |
PCT/US2006/005367 WO2006088972A2 (en) | 2005-02-16 | 2006-02-16 | Use of modulatirs of compounds of tgf-beta superfamily to regulate hepcidin-mediated iron metabolism |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1116660A1 true HK1116660A1 (en) | 2009-01-02 |
Family
ID=36917026
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08105989.4A HK1116660A1 (en) | 2005-02-16 | 2008-05-28 | Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency bmp |
HK16106934.8A HK1218875A1 (zh) | 2005-02-16 | 2016-06-16 | 拮抗劑以調節鐵調素介導的鐵代謝的用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16106934.8A HK1218875A1 (zh) | 2005-02-16 | 2016-06-16 | 拮抗劑以調節鐵調素介導的鐵代謝的用途 |
Country Status (7)
Country | Link |
---|---|
US (6) | US7968091B2 (xx) |
EP (3) | EP1858541B1 (xx) |
JP (4) | JP5063366B2 (xx) |
CA (1) | CA2597925A1 (xx) |
ES (2) | ES2547866T3 (xx) |
HK (2) | HK1116660A1 (xx) |
WO (1) | WO2006088972A2 (xx) |
Families Citing this family (48)
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WO2002051438A2 (en) | 2000-12-22 | 2002-07-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (rgm) and its modulators |
EP1392345B2 (en) | 2001-05-25 | 2018-02-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
WO2006012627A2 (en) | 2004-07-23 | 2006-02-02 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
JP5063366B2 (ja) * | 2005-02-16 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
US20070099245A1 (en) * | 2005-09-29 | 2007-05-03 | Boris Gorovits | Assays for neutralizing antibodies |
CN101277974A (zh) | 2005-09-30 | 2008-10-01 | 阿伯特有限及两合公司 | 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途 |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
JP5261187B2 (ja) | 2005-11-23 | 2013-08-14 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIaアンタゴニストおよび骨成長を促進するための使用 |
EA035911B1 (ru) | 2006-12-18 | 2020-08-31 | Акселерон Фарма Инк. | Применение полипептида, который ингибирует опосредованный активином сигнальный путь, в качестве лекарственного средства |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
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CN104548056B (zh) | 2007-02-09 | 2022-09-09 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和促进癌症患者骨骼生长的用途 |
WO2008124768A1 (en) * | 2007-04-09 | 2008-10-16 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
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CA2742871C (en) * | 2008-11-13 | 2018-10-23 | Herb Lin | Methods and compositions for regulating iron homeostasis by modulation of bmp-6 |
WO2010059861A1 (en) * | 2008-11-20 | 2010-05-27 | University Of Southern California | Compositions and methods to modulate hair growth |
CA2749544A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
EP2440576A4 (en) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | PROCESS FOR INCREASING THE NUMBER OF THERMOUS ADIPOCYTES |
KR20120028358A (ko) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
MX2012006560A (es) | 2009-12-08 | 2012-10-05 | Abbott Gmbh & Co Kg | Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal. |
AU2011326586A1 (en) | 2010-11-08 | 2013-05-30 | Acceleron Pharma, Inc. | ActRIIA binding agents and uses thereof |
CA2825163C (en) * | 2011-01-19 | 2019-12-03 | Ferrumax Pharmaceuticals, Inc. | Compositions for regulating iron homeostasis and methods of using same |
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CA2855570A1 (en) * | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
RS57603B1 (sr) | 2012-01-27 | 2018-11-30 | Abbvie Deutschland | Sastav i metod za dijagnozu i tretiranje bolesti povezanih sa degeneracijom neurita |
EP2914619B1 (en) * | 2012-11-01 | 2019-05-29 | The Regents of The University of California | Erythroferrone and erfe polypeptides and methods of regulating iron metabolism |
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EP2976085A1 (en) * | 2013-03-21 | 2016-01-27 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
CN105659087B (zh) * | 2013-06-13 | 2019-09-17 | 比奥德赛公司 | 筛选靶向靶生物实体的候选生物实体的方法 |
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MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
PT3227675T (pt) | 2014-12-03 | 2023-05-30 | Celgene Corp | Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica |
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US11124766B2 (en) * | 2015-06-12 | 2021-09-21 | Emory University | Growth and survival compositions for cells capable of producing antibodies and methods related thereto |
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KR20240027854A (ko) | 2017-03-02 | 2024-03-04 | 내셔날 리서치 카운실 오브 캐나다 | Tgf-β-수용체 엑토도메인 융합 분자 및 그의 용도 |
US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
AU2020356575A1 (en) * | 2019-09-27 | 2022-04-14 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
US20220372136A1 (en) * | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating anemia of chronic disease |
WO2022098821A1 (en) * | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating lymphopenia |
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CN1159063C (zh) * | 2000-06-21 | 2004-07-28 | 中国医学科学院血液学研究所 | 骨形态发生蛋白(bmp)作为治疗急性再生障碍性贫血药物的应用 |
WO2002051438A2 (en) | 2000-12-22 | 2002-07-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (rgm) and its modulators |
EP1392345B2 (en) * | 2001-05-25 | 2018-02-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
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WO2005028517A2 (en) * | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
JP5063366B2 (ja) * | 2005-02-16 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
CA2549477A1 (en) | 2005-06-29 | 2006-12-29 | The Regents Of The University Of California | Competitive regulation of hepcidin mrna by soluble and cell-associated hemojuvelin |
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2006
- 2006-02-16 JP JP2007556264A patent/JP5063366B2/ja not_active Expired - Fee Related
- 2006-02-16 WO PCT/US2006/005367 patent/WO2006088972A2/en active Application Filing
- 2006-02-16 US US11/884,509 patent/US7968091B2/en active Active
- 2006-02-16 EP EP06735151A patent/EP1858541B1/en not_active Revoked
- 2006-02-16 EP EP15173396.1A patent/EP2954903A1/en not_active Withdrawn
- 2006-02-16 EP EP10196139.9A patent/EP2335719B1/en active Active
- 2006-02-16 ES ES10196139.9T patent/ES2547866T3/es active Active
- 2006-02-16 CA CA002597925A patent/CA2597925A1/en not_active Abandoned
- 2006-02-16 ES ES06735151T patent/ES2392096T3/es active Active
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2008
- 2008-05-28 HK HK08105989.4A patent/HK1116660A1/xx not_active IP Right Cessation
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2011
- 2011-06-28 US US13/171,438 patent/US8293236B2/en active Active
- 2011-12-02 JP JP2011264338A patent/JP5852426B2/ja not_active Expired - Fee Related
-
2012
- 2012-02-28 US US13/407,502 patent/US8637023B2/en active Active
- 2012-10-18 US US13/654,623 patent/US8865168B2/en active Active
-
2014
- 2014-05-29 JP JP2014111127A patent/JP6073833B2/ja active Active
- 2014-07-16 US US14/332,716 patent/US9556251B2/en active Active
-
2016
- 2016-06-16 HK HK16106934.8A patent/HK1218875A1/zh unknown
- 2016-09-21 JP JP2016183644A patent/JP6250764B2/ja active Active
- 2016-12-12 US US15/375,491 patent/US20170183411A1/en not_active Abandoned
Also Published As
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US20170183411A1 (en) | 2017-06-29 |
JP2012126722A (ja) | 2012-07-05 |
JP2008530222A (ja) | 2008-08-07 |
US20080260736A1 (en) | 2008-10-23 |
US8637023B2 (en) | 2014-01-28 |
US20120258105A1 (en) | 2012-10-11 |
US8865168B2 (en) | 2014-10-21 |
EP2335719B1 (en) | 2015-06-24 |
CA2597925A1 (en) | 2006-08-24 |
EP1858541A2 (en) | 2007-11-28 |
EP1858541B1 (en) | 2012-07-25 |
JP6073833B2 (ja) | 2017-02-01 |
JP2014159478A (ja) | 2014-09-04 |
WO2006088972A3 (en) | 2007-04-19 |
EP2954903A1 (en) | 2015-12-16 |
US20150072927A1 (en) | 2015-03-12 |
JP5852426B2 (ja) | 2016-02-03 |
JP5063366B2 (ja) | 2012-10-31 |
WO2006088972A2 (en) | 2006-08-24 |
JP6250764B2 (ja) | 2017-12-20 |
US7968091B2 (en) | 2011-06-28 |
ES2547866T3 (es) | 2015-10-09 |
US8293236B2 (en) | 2012-10-23 |
JP2016222716A (ja) | 2016-12-28 |
HK1218875A1 (zh) | 2017-03-17 |
US9556251B2 (en) | 2017-01-31 |
US20120064076A1 (en) | 2012-03-15 |
ES2392096T3 (es) | 2012-12-04 |
US20130149304A1 (en) | 2013-06-13 |
EP2335719A1 (en) | 2011-06-22 |
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Effective date: 20230216 |