HK1080447B - 視黃醇衍生物、它們在治療癌症和增强其它細胞毒性劑功效中的應用 - Google Patents

視黃醇衍生物、它們在治療癌症和增强其它細胞毒性劑功效中的應用

Info

Publication number
HK1080447B
HK1080447B HK06100168.0A HK06100168A HK1080447B HK 1080447 B HK1080447 B HK 1080447B HK 06100168 A HK06100168 A HK 06100168A HK 1080447 B HK1080447 B HK 1080447B
Authority
HK
Hong Kong
Prior art keywords
potentiating
efficacy
cancer
treatment
cytotoxic agents
Prior art date
Application number
HK06100168.0A
Other languages
English (en)
Other versions
HK1080447A1 (en
Inventor
Oleg Strelchenok
Julian Aleksov
Original Assignee
Oasmia Pharmaceutical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0202311A external-priority patent/SE0202311D0/xx
Application filed by Oasmia Pharmaceutical Ab filed Critical Oasmia Pharmaceutical Ab
Publication of HK1080447A1 publication Critical patent/HK1080447A1/xx
Publication of HK1080447B publication Critical patent/HK1080447B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK06100168.0A 2002-07-23 2006-01-04 視黃醇衍生物、它們在治療癌症和增强其它細胞毒性劑功效中的應用 HK1080447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39820002P 2002-07-23 2002-07-23
SE0202311A SE0202311D0 (sv) 2002-07-23 2002-07-23 Novel compounds, cytotoxic preparations comprising said compounds, methods of manufacture of said preparations, as well as methods of treatment
PCT/SE2002/002087 WO2004009538A1 (en) 2002-07-23 2002-11-15 Retinol derivatives, their use in the treatment of cancer and for potentiating the efficacy of other cytotoxic agents

Publications (2)

Publication Number Publication Date
HK1080447A1 HK1080447A1 (en) 2006-04-28
HK1080447B true HK1080447B (zh) 2008-10-31

Family

ID=30772317

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06100168.0A HK1080447B (zh) 2002-07-23 2006-01-04 視黃醇衍生物、它們在治療癌症和增强其它細胞毒性劑功效中的應用

Country Status (5)

Country Link
EP (1) EP1534672B1 (zh)
CN (1) CN100360502C (zh)
AU (1) AU2002347747A1 (zh)
HK (1) HK1080447B (zh)
WO (1) WO2004009538A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101547898B (zh) 2006-12-10 2014-09-24 于崇曦 β-内酰胺类抗生素的透皮给药系统
CN105439928B (zh) * 2007-01-15 2021-06-15 于崇曦 维生素a酸类和类维生素a酸化合物的前药
CN101605754B (zh) * 2007-01-15 2015-09-16 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的维生素a酸类和类维生素a酸化合物的前药
WO2009078754A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of poorly water soluble pharmaceutically active substances
CA2732412C (en) * 2008-07-30 2014-12-09 Lei Yu Retinoid-targeted drug carriers
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
EP2420228A1 (en) * 2010-08-05 2012-02-22 Alpinia Laudanum Institute Of Phytopharmaceutical Sciences AG Composition comprising retinol, a precursor or a reaction product of it and a plant extract from at least one chamomilla plant for the treatment of cancer
CN107929743B (zh) 2012-01-18 2023-09-01 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
JP7009012B2 (ja) * 2015-12-09 2022-01-25 オアスミア ファーマシューティカル アーベー Ｎ－レチノイルシステイン酸アルキルエステルの製造方法
CN107149684B (zh) * 2017-05-08 2019-10-25 西南大学 半胱氨酸双加氧酶、基因及其催化产物半胱亚磺酸的新用途
CN110218168B (zh) * 2018-03-02 2022-09-20 上海现代药物制剂工程研究中心有限公司 一种n-(全反式-视黄酰基)-l-半胱磺酸甲酯的钠盐的制备方法
JP2019006795A (ja) * 2018-08-27 2019-01-17 チョンシー ユー 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ
CN112321465B (zh) * 2019-07-18 2023-06-06 上海现代药物制剂工程研究中心有限公司 一种含苯基化合物、其中间体、制备方法及应用
CN112239418B (zh) * 2019-07-18 2023-07-07 上海现代药物制剂工程研究中心有限公司 视黄醇类化合物及其钠盐的制备方法
WO2021259472A1 (en) 2020-06-24 2021-12-30 Oasmia Pharmaceutical Ab Micellar docetaxel for use in the treatment of cancer
WO2024068553A1 (en) 2022-09-26 2024-04-04 Vivesto Ab Solubilizing compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4032187C2 (de) 1990-10-10 1995-03-30 Gradinger F Hermes Pharma N-Retinoyl-L-aminomercapto-Verbindungen und Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung
SE9900941D0 (sv) * 1998-12-23 1999-03-16 Nomet Management Serv Bv Novel retinoic acid derivatives and their use
SE0101702D0 (sv) * 2001-05-15 2001-05-15 Ardenia Investments Ltd Novel potentiating compounds
US9502585B2 (en) 2015-04-17 2016-11-22 Taiwan Semiconductor Manufacturing Co., Ltd. Schottky barrier diode and method of manufacturing the same

Also Published As

Publication number Publication date
EP1534672B1 (en) 2013-05-01
EP1534672A1 (en) 2005-06-01
CN1668583A (zh) 2005-09-14
CN100360502C (zh) 2008-01-09
HK1080447A1 (en) 2006-04-28
WO2004009538A1 (en) 2004-01-29
AU2002347747A1 (en) 2004-02-09

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Legal Events

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PE Patent expired

Effective date: 20221111