HK1079984A1 - 抑制hiv複製的甘氨酰胺衍生物 - Google Patents
抑制hiv複製的甘氨酰胺衍生物Info
- Publication number
- HK1079984A1 HK1079984A1 HK06100030.6A HK06100030A HK1079984A1 HK 1079984 A1 HK1079984 A1 HK 1079984A1 HK 06100030 A HK06100030 A HK 06100030A HK 1079984 A1 HK1079984 A1 HK 1079984A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hiv replication
- inhibiting hiv
- glycinamide derivative
- glycinamide
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44949403P | 2003-02-21 | 2003-02-21 | |
US49389303P | 2003-08-08 | 2003-08-08 | |
US50521703P | 2003-09-22 | 2003-09-22 | |
PCT/IB2004/000865 WO2004073703A1 (en) | 2003-02-21 | 2004-02-19 | Glycinamide derivative for inhibiting hiv replication |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1079984A1 true HK1079984A1 (zh) | 2006-04-21 |
Family
ID=32913030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06100030.6A HK1079984A1 (zh) | 2003-02-21 | 2006-01-03 | 抑制hiv複製的甘氨酰胺衍生物 |
Country Status (10)
Country | Link |
---|---|
US (3) | US20040180893A1 (zh) |
EP (1) | EP1603546A1 (zh) |
JP (1) | JP2006518373A (zh) |
KR (1) | KR20050101221A (zh) |
AU (1) | AU2004212786A1 (zh) |
CA (1) | CA2515679A1 (zh) |
HK (1) | HK1079984A1 (zh) |
NZ (1) | NZ541883A (zh) |
PL (1) | PL378163A1 (zh) |
WO (1) | WO2004073703A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
NZ541883A (en) * | 2003-02-21 | 2008-12-24 | Tripep Ab | Glycinamide derivative for inhibiting HIV replication |
GB0310593D0 (en) * | 2003-05-08 | 2003-06-11 | Leuven K U Res & Dev | Peptidic prodrugs |
TW201414495A (zh) | 2005-04-04 | 2014-04-16 | Tibotec Pharm Ltd | Hiv-感染之預防 |
CA2845933C (en) | 2011-09-06 | 2020-06-09 | New York Blood Center, Inc. | Hiv inhibitors |
AU2012335220B2 (en) | 2011-11-11 | 2017-06-01 | Pfizer Inc. | 2-thiopyrimidinones |
WO2016044808A1 (en) | 2014-09-19 | 2016-03-24 | New York Blood Center, Inc. | Substituted phenylpyrrolecarboxamides with therapeutic activity in hiv |
CN104402821A (zh) * | 2014-12-04 | 2015-03-11 | 贾正平 | 具有抗缺氧损伤活性的氮氧自由基类化合物及其制备和应用 |
MX2017014128A (es) | 2015-05-05 | 2018-03-15 | Pfizer | 2-tiopirimidinonas. |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US166694A (en) * | 1875-08-17 | Improvement in horse hay-forks | ||
US232804A (en) * | 1880-10-05 | Alonzo t | ||
US91086A (en) * | 1869-06-08 | Improved furniture-caster | ||
US1063727A (en) * | 1912-07-31 | 1913-06-03 | William J Pierce | Bed-caster. |
GB1160955A (en) * | 1965-10-11 | 1969-08-13 | Agfa Gevaert Nv | New Light-Developable Photographic Material and Recording Process |
US4215112A (en) * | 1979-03-14 | 1980-07-29 | Ortho Pharmaceutical Corporation | Tripeptides and methods |
US4658013A (en) * | 1981-07-28 | 1987-04-14 | Sterling Drug Inc. | Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof |
CS231228B1 (en) * | 1982-10-01 | 1984-10-15 | Evzen Kasafirek | Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method |
JPS60243017A (ja) * | 1984-05-16 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | 抗けいれん組成物 |
US4818540A (en) * | 1985-02-25 | 1989-04-04 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
US4612337A (en) * | 1985-05-30 | 1986-09-16 | The Trustees Of Columbia University In The City Of New York | Method for preparing infection-resistant materials |
US4833148A (en) * | 1987-04-09 | 1989-05-23 | Washington University | Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury |
US4857538A (en) * | 1987-11-30 | 1989-08-15 | The Research Foundation Of State University Of New York | New compounds for the study and treatment of microfilament organization in cells |
US4950647A (en) * | 1988-10-04 | 1990-08-21 | Nucleic Acid Research Institute | T cell immunopotentiator |
US5336758A (en) * | 1990-03-09 | 1994-08-09 | The United States Of America As Represented By The Department Of Health And Human Services | Peptides stimulating cytotoxic T cells immune to HIV RT |
DE4014655A1 (de) * | 1990-05-08 | 1991-11-14 | Behringwerke Ag | Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren |
US5627035A (en) * | 1990-08-22 | 1997-05-06 | Syntello Vaccine Development Ab | Peptides that block human immunodeficiency virus and methods of use thereof |
US5346989A (en) * | 1990-08-22 | 1994-09-13 | Syntello Vaccine Development Kb | Peptides for use in induction of T cell activation against HIV-1 |
BR9105902A (pt) * | 1990-09-11 | 1994-06-28 | Seikagaku Kogyo Co Ltd | Novo polipeptídeo |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
JP3266311B2 (ja) * | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗hiv剤 |
NO921715L (no) * | 1991-05-02 | 1992-11-03 | Seikagaku Kogyo Co Ltd | Nye polypeptider med affinitet for lipopolysakkarider og anvendelser derav |
WO1992020795A1 (en) * | 1991-05-17 | 1992-11-26 | Cetus Oncology Corporation | INHIBITOR OF NF-λB TRANSCRIPTIONAL ACTIVATOR AND USES THEREOF |
JPH0597789A (ja) * | 1991-10-03 | 1993-04-20 | Nippon Chibagaigii Kk | α−ヒドロキシグリシンアミド誘導体及びその製造方法 |
JPH08509119A (ja) * | 1993-01-28 | 1996-10-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Tata結合蛋白関連因子、tafをコードする核酸および使用方法 |
US5856122A (en) * | 1993-08-24 | 1999-01-05 | University Of Alberta | Modification of pertussis toxin |
FR2710340B1 (fr) * | 1993-09-22 | 1995-12-15 | D Hinterland Lucien Dussourd | Dérivés peptidiques de l'alpha-MSH et leur application . |
US5470951A (en) * | 1993-09-29 | 1995-11-28 | City Of Hope | Peptides for antagonizing the effects of amyloid βprotein |
ATE177114T1 (de) * | 1993-10-14 | 1999-03-15 | Seikagaku Kogyo Co Ltd | Polypeptide und daraus hergestellte, gegen hiv wirksame substanzen |
US5744368A (en) * | 1993-11-04 | 1998-04-28 | Research Foundation Of State University Of New York | Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR) |
DE4431317A1 (de) * | 1994-09-02 | 1996-03-07 | Biotechnolog Forschung Gmbh | Schutz- bzw. Ankergruppen und deren Verwendung |
EP0815134B1 (en) * | 1995-03-14 | 2002-06-05 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
US5817626A (en) * | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
US5770620A (en) * | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
US5872210A (en) * | 1995-10-05 | 1999-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Transframe peptide inhibitor of viral protease |
US5830910A (en) * | 1995-10-23 | 1998-11-03 | University Of Kentucky Research Foundation | Cytochalasins useful in providing protection against nerve cell injury associated with neurodegenerative disorders |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
WO1997037228A1 (en) * | 1996-03-29 | 1997-10-09 | The Trustees Of Boston University | Methods for diagnosing and treating alzheimer's disease |
US5886025A (en) * | 1997-03-06 | 1999-03-23 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
US5843995A (en) * | 1997-07-07 | 1998-12-01 | University Of Medicine And Dentistry Of New Jersey | Inhibition of HIV-1 replication using oligocarbamate derivatives |
US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
US6258932B1 (en) * | 1999-08-09 | 2001-07-10 | Tripep Ab | Peptides that block viral infectivity and methods of use thereof |
DE10027025A1 (de) * | 2000-05-31 | 2001-12-06 | Merck Patent Gmbh | Clycinamide |
US6455670B1 (en) * | 2001-09-06 | 2002-09-24 | Tripep Ab | Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof |
WO2003024995A1 (en) * | 2001-09-19 | 2003-03-27 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
AU2002350217A1 (en) * | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
NZ541883A (en) * | 2003-02-21 | 2008-12-24 | Tripep Ab | Glycinamide derivative for inhibiting HIV replication |
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
-
2004
- 2004-02-19 NZ NZ541883A patent/NZ541883A/en unknown
- 2004-02-19 EP EP04712638A patent/EP1603546A1/en not_active Withdrawn
- 2004-02-19 PL PL378163A patent/PL378163A1/pl unknown
- 2004-02-19 AU AU2004212786A patent/AU2004212786A1/en not_active Abandoned
- 2004-02-19 JP JP2006502493A patent/JP2006518373A/ja active Pending
- 2004-02-19 KR KR1020057015375A patent/KR20050101221A/ko not_active Application Discontinuation
- 2004-02-19 US US10/783,053 patent/US20040180893A1/en not_active Abandoned
- 2004-02-19 WO PCT/IB2004/000865 patent/WO2004073703A1/en active Application Filing
- 2004-02-19 CA CA002515679A patent/CA2515679A1/en not_active Abandoned
-
2006
- 2006-01-03 HK HK06100030.6A patent/HK1079984A1/zh unknown
- 2006-04-24 US US11/409,671 patent/US20060188920A1/en not_active Abandoned
-
2007
- 2007-10-30 US US11/929,695 patent/US20090170953A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL378163A1 (pl) | 2006-03-06 |
US20040180893A1 (en) | 2004-09-16 |
US20090170953A1 (en) | 2009-07-02 |
CA2515679A1 (en) | 2004-09-02 |
WO2004073703B1 (en) | 2004-11-04 |
AU2004212786A1 (en) | 2004-09-02 |
NZ541883A (en) | 2008-12-24 |
KR20050101221A (ko) | 2005-10-20 |
JP2006518373A (ja) | 2006-08-10 |
US20060188920A1 (en) | 2006-08-24 |
EP1603546A1 (en) | 2005-12-14 |
WO2004073703A1 (en) | 2004-09-02 |
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