HK1064940A1 - Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity - Google Patents

Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity

Info

Publication number
HK1064940A1
HK1064940A1 HK04107740.4A HK04107740A HK1064940A1 HK 1064940 A1 HK1064940 A1 HK 1064940A1 HK 04107740 A HK04107740 A HK 04107740A HK 1064940 A1 HK1064940 A1 HK 1064940A1
Authority
HK
Hong Kong
Prior art keywords
oxazin
thieno
ones
inhibiting activity
lipase inhibiting
Prior art date
Application number
HK04107740.4A
Other languages
English (en)
Inventor
Harold Francis Hodson
Christopher R Dunk
Richard M J Palmer
Dale Robert Mitchell
Veronique Birault
Russell George Hunt
Original Assignee
Alizyme Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121019A external-priority patent/GB0121019D0/en
Priority claimed from GB0206031A external-priority patent/GB0206031D0/en
Application filed by Alizyme Therapeutics Ltd filed Critical Alizyme Therapeutics Ltd
Publication of HK1064940A1 publication Critical patent/HK1064940A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK04107740.4A 2001-08-30 2004-10-07 Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity HK1064940A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0121019A GB0121019D0 (en) 2001-08-30 2001-08-30 /nhibitors
GB0206031A GB0206031D0 (en) 2002-03-14 2002-03-14 Inhibitors
PCT/GB2002/003903 WO2003020282A1 (en) 2001-08-30 2002-08-23 Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity

Publications (1)

Publication Number Publication Date
HK1064940A1 true HK1064940A1 (en) 2005-02-08

Family

ID=26246489

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04107740.4A HK1064940A1 (en) 2001-08-30 2004-10-07 Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity

Country Status (20)

Country Link
US (2) US7407954B2 (xx)
EP (1) EP1446125B1 (xx)
JP (2) JP2005527469A (xx)
KR (1) KR100934256B1 (xx)
CN (1) CN1556706B (xx)
AR (1) AR036399A1 (xx)
AT (1) ATE429918T1 (xx)
AU (1) AU2002321536B2 (xx)
CA (1) CA2458213A1 (xx)
DE (1) DE60232170D1 (xx)
HK (1) HK1064940A1 (xx)
HU (1) HUP0401298A3 (xx)
MX (1) MXPA04001922A (xx)
MY (1) MY139608A (xx)
NO (1) NO20041295L (xx)
NZ (1) NZ531272A (xx)
PL (1) PL368994A1 (xx)
RU (1) RU2324696C2 (xx)
WO (1) WO2003020282A1 (xx)
ZA (1) ZA200401595B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100934256B1 (ko) * 2001-08-30 2009-12-28 알리자임 테라퓨틱스 리미티드 리파제 억제 활성을 갖는 티에노(1,3)옥사진-4-온
JP4668536B2 (ja) * 2001-12-20 2011-04-13 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 膵臓リパーゼ阻害化合物、その合成および使用
EP1802634A2 (en) * 2004-10-20 2007-07-04 Compass Pharmaceuticals LLC Thiophens and their use as anti-tumor agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
DE3540377A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Thienooxazinone, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer
IL125947A0 (en) 1997-09-17 1999-04-11 American Cyanamid Co 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1h,3h)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3)-pyrimidinone or thione herbicidal agents
EP0985670A1 (en) 1998-08-13 2000-03-15 American Cyanamid Company 1-(3-Heterocyclylphenyl)isothiourea, -isourea, -guanidine and -amidine compounds as herbicides
WO2000030646A1 (en) 1998-11-26 2000-06-02 Novo Nordisk A/S Heterocyclic compounds regulating clotting
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
WO2001018181A2 (en) 1999-09-10 2001-03-15 The Procter & Gamble Company Enzyme inhibitors
GB0001572D0 (en) 2000-01-24 2000-03-15 Alizyme Therapeutics Ltd Inhibitors
JP2002105081A (ja) * 2000-07-28 2002-04-10 Nikken Chem Co Ltd 新規チオフェンニ環化合物
KR100934256B1 (ko) * 2001-08-30 2009-12-28 알리자임 테라퓨틱스 리미티드 리파제 억제 활성을 갖는 티에노(1,3)옥사진-4-온
JP4668536B2 (ja) * 2001-12-20 2011-04-13 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 膵臓リパーゼ阻害化合物、その合成および使用

Also Published As

Publication number Publication date
RU2324696C2 (ru) 2008-05-20
US7407954B2 (en) 2008-08-05
NZ531272A (en) 2006-01-27
CN1556706B (zh) 2011-04-27
RU2004109588A (ru) 2005-05-10
DE60232170D1 (de) 2009-06-10
ATE429918T1 (de) 2009-05-15
NO20041295L (no) 2004-03-29
MXPA04001922A (es) 2005-03-07
EP1446125B1 (en) 2009-04-29
MY139608A (en) 2009-10-30
KR100934256B1 (ko) 2009-12-28
WO2003020282A1 (en) 2003-03-13
CA2458213A1 (en) 2003-03-13
US20050075336A1 (en) 2005-04-07
AR036399A1 (es) 2004-09-08
CN1556706A (zh) 2004-12-22
ZA200401595B (en) 2005-05-25
JP2010159260A (ja) 2010-07-22
HUP0401298A3 (en) 2008-03-28
HUP0401298A2 (hu) 2004-10-28
AU2002321536B2 (en) 2007-05-17
US20090029978A1 (en) 2009-01-29
PL368994A1 (en) 2005-04-04
EP1446125A1 (en) 2004-08-18
KR20040052216A (ko) 2004-06-22
JP2005527469A (ja) 2005-09-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140823