HK1050695A1 - Methods for generating human monoclonal antibodies - Google Patents

Methods for generating human monoclonal antibodies

Info

Publication number
HK1050695A1
HK1050695A1 HK03102508.8A HK03102508A HK1050695A1 HK 1050695 A1 HK1050695 A1 HK 1050695A1 HK 03102508 A HK03102508 A HK 03102508A HK 1050695 A1 HK1050695 A1 HK 1050695A1
Authority
HK
Hong Kong
Prior art keywords
monoclonal antibodies
methods
human monoclonal
generating human
cell type
Prior art date
Application number
HK03102508.8A
Other languages
English (en)
Inventor
Ronghao Li
Original Assignee
Macrogenics West Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics West Inc filed Critical Macrogenics West Inc
Publication of HK1050695A1 publication Critical patent/HK1050695A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK03102508.8A 2000-01-26 2003-04-09 Methods for generating human monoclonal antibodies HK1050695A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/491,894 US6541225B1 (en) 2000-01-26 2000-01-26 Methods and compositions for generating human monoclonal antibodies
PCT/US2001/002588 WO2001055216A1 (en) 2000-01-26 2001-01-26 Methods and compositions for generating human monoclonal antibodies

Publications (1)

Publication Number Publication Date
HK1050695A1 true HK1050695A1 (en) 2003-07-04

Family

ID=23954109

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03102508.8A HK1050695A1 (en) 2000-01-26 2003-04-09 Methods for generating human monoclonal antibodies

Country Status (11)

Country Link
US (3) US6541225B1 (ja)
EP (1) EP1255780B1 (ja)
JP (1) JP4790959B2 (ja)
KR (1) KR20020073185A (ja)
CN (1) CN100491397C (ja)
AT (1) ATE439380T1 (ja)
AU (2) AU2001231172B2 (ja)
CA (1) CA2398284A1 (ja)
DE (1) DE60139542D1 (ja)
HK (1) HK1050695A1 (ja)
WO (1) WO2001055216A1 (ja)

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US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US7771999B2 (en) * 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7855074B2 (en) * 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
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AU2006210606B2 (en) * 2005-02-03 2012-03-22 Macrogenics West, Inc. Antibodies to Oncostatin M receptor
ZA200707275B (en) * 2005-02-04 2009-01-28 Raven Biotechnologies Inc Antibodies that bind to EphA2 and methods of use thereof
US8945857B2 (en) * 2005-07-01 2015-02-03 John Schrader Methods of isolating cells and generating monoclonal antibodies
CA2634123C (en) 2005-12-21 2015-11-24 Vaxdesign Corporation In vitro germinal centers
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US7709257B2 (en) * 2006-06-27 2010-05-04 Vax Design Corp. Models for vaccine assessment
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EP2420516A1 (en) * 2007-07-06 2012-02-22 Sanofi Pasteur VaxDesign Corporation Rapid generation of T cell-independent antibody responses to T cell-dependent antigens
US8647837B2 (en) * 2007-07-16 2014-02-11 Sanofi Pasteur Vaxdesign Corp. Artificial tissue constructs comprising alveolar cells and methods for using the same
WO2009020923A1 (en) 2007-08-03 2009-02-12 Musc Foundation For Research Development Human monoclonal antibodies and methods for producing the same
WO2009054556A1 (en) * 2007-10-24 2009-04-30 Sang Yun Nam Method for preparation of therapeutic b cells against autoimmune diseases which are induced by autoimmune cytotoxicity
US20100248971A1 (en) * 2007-12-03 2010-09-30 Takashi Inagaki Process for antibody production
US8999707B2 (en) * 2008-01-28 2015-04-07 Thomas Jefferson University Method of making hybrid cells that express useful antibodies
JP5785490B2 (ja) 2008-04-02 2015-09-30 マクロジェニクス，インコーポレーテッド Ｂｃｒ複合体特異的抗体およびその使用方法
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
PE20170779A1 (es) 2010-03-04 2017-07-04 Macrogenics Inc Anticuerpos reactivos con b7-h3, fragmentos inmunologicamente activos de los mismos y usos de los mismos
SI2400298T1 (sl) * 2010-05-28 2013-11-29 F. Hoffmann-La Roche Ag Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles
TWI477603B (zh) * 2011-01-28 2015-03-21 Hon Hai Prec Ind Co Ltd 培育基體之製備方法
EP3020728A1 (en) 2011-06-23 2016-05-18 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
KR102240318B1 (ko) 2011-06-23 2021-04-15 아블린쓰 엔.브이. 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법
US20140287402A1 (en) * 2011-06-27 2014-09-25 Valneva Method for screening cells
CN102321720B (zh) * 2011-07-28 2014-09-03 万晓春 一种混合细胞培养生产纯人源单克隆抗体的方法
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3
EP2727943A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispecific antibodies against human EGFR, HER2 and HER3
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WO2016207304A2 (en) 2015-06-26 2016-12-29 Mab Discovery Gmbh Monoclonal anti-il-1racp antibodies
US10222373B2 (en) 2016-02-29 2019-03-05 Rarecyte, Inc. Method to identify antigen-specific immune cells
US9442113B1 (en) 2016-02-29 2016-09-13 Rarecyte, Inc. Method to identify antigen-specific immune cells for therapeutic development
US9395367B1 (en) 2016-02-29 2016-07-19 Rarecyte, Inc. Method to identify antigen-specific B cells for antibody development
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US20210277118A1 (en) * 2018-06-21 2021-09-09 Daiichi Sankyo Company, Limited Compositions including cd3 antigen binding fragments and uses thereof

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Also Published As

Publication number Publication date
WO2001055216A1 (en) 2001-08-02
US6541225B1 (en) 2003-04-01
CN1420893A (zh) 2003-05-28
CN100491397C (zh) 2009-05-27
KR20020073185A (ko) 2002-09-19
US20030109006A1 (en) 2003-06-12
EP1255780B1 (en) 2009-08-12
US20060252124A1 (en) 2006-11-09
AU2001231172B2 (en) 2006-05-25
CA2398284A1 (en) 2001-08-02
AU3117201A (en) 2001-08-07
JP4790959B2 (ja) 2011-10-12
EP1255780A1 (en) 2002-11-13
DE60139542D1 (de) 2009-09-24
US8137668B2 (en) 2012-03-20
JP2003531578A (ja) 2003-10-28
ATE439380T1 (de) 2009-08-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140126