HK1046897B - 製備n-[(脂族或芳族)羰基)]-2-氨基乙酰胺化合物和環化這種化合物的方法 - Google Patents
製備n-[(脂族或芳族)羰基)]-2-氨基乙酰胺化合物和環化這種化合物的方法Info
- Publication number
- HK1046897B HK1046897B HK02108269.5A HK02108269A HK1046897B HK 1046897 B HK1046897 B HK 1046897B HK 02108269 A HK02108269 A HK 02108269A HK 1046897 B HK1046897 B HK 1046897B
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- Prior art keywords
- compounds
- preparing
- carbonyl
- aliphatic
- aromatic
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- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000001931 aliphatic group Chemical group 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
Classifications
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C07C231/00—Preparation of carboxylic acid amides
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- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
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- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/368,213 US6492553B1 (en) | 1998-01-29 | 1999-08-04 | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
PCT/US2000/021257 WO2001010799A1 (en) | 1999-08-04 | 2000-08-03 | Methods for preparing n-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compounds and for cyclizing such compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1046897A1 HK1046897A1 (en) | 2003-01-30 |
HK1046897B true HK1046897B (zh) | 2005-04-15 |
Family
ID=23450331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02108269.5A HK1046897B (zh) | 1999-08-04 | 2002-11-15 | 製備n-[(脂族或芳族)羰基)]-2-氨基乙酰胺化合物和環化這種化合物的方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6492553B1 (zh) |
EP (1) | EP1212269B1 (zh) |
JP (1) | JP2003506420A (zh) |
AT (1) | ATE280744T1 (zh) |
AU (1) | AU6757400A (zh) |
DE (1) | DE60015371T2 (zh) |
ES (1) | ES2230143T3 (zh) |
HK (1) | HK1046897B (zh) |
WO (1) | WO2001010799A1 (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1243263T3 (da) * | 2001-03-21 | 2003-03-17 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte |
DK1443937T3 (da) * | 2001-11-13 | 2008-10-20 | Ortho Mcneil Pharm Inc | Substituerede 1,4-benzodiazepiner samt deres anvendelse til behnadling af cancer |
AU2003284165B2 (en) * | 2002-10-30 | 2008-12-11 | Merck Sharp & Dohme Corp. | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
US20040213264A1 (en) * | 2003-04-25 | 2004-10-28 | Nortel Networks Limited | Service class and destination dominance traffic management |
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
JP4664924B2 (ja) * | 2003-12-02 | 2011-04-06 | ウーツェーベー ファルマ ゲーエムベーハー | 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用 |
US7507760B2 (en) * | 2004-01-22 | 2009-03-24 | Neuromed Pharmaceuticals Ltd. | N-type calcium channel blockers |
US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
EP1987009A1 (en) * | 2006-01-30 | 2008-11-05 | Euro-Celtique S.A. | Cyclourea compounds as calcium channel blockers |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
EP2037965B1 (en) | 2006-06-15 | 2017-08-30 | UCB Pharma GmbH | Pharmaceutical composition with synergistic anticonvulsant effect |
US7629351B2 (en) | 2006-07-28 | 2009-12-08 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process |
US7671062B2 (en) | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
US7687508B2 (en) | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
BRPI0809930A2 (pt) | 2007-04-03 | 2014-10-07 | Glaxo Group Ltd | Derivados de carboxamida imidazolidina como moduladores de p2x7 |
US8703119B2 (en) | 2007-10-05 | 2014-04-22 | Polygene Ltd. | Injectable biodegradable polymer compositions for soft tissue repair and augmentation |
JP2010029845A (ja) * | 2008-06-23 | 2010-02-12 | Tosoh Corp | 蛋白質精製用分離剤及び蛋白質精製方法 |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
AU2010204723A1 (en) * | 2009-01-14 | 2011-08-18 | The Salk Institute For Biological Studies | Methods for screening and compounds that protect against amyloid diseases |
EP2408802B1 (en) * | 2009-03-16 | 2017-05-03 | The Governing Council of the University of Toronto | Cyclic amino acid molecules and methods of preparing the same |
US8629149B2 (en) * | 2009-09-04 | 2014-01-14 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
US8383812B2 (en) | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
EP2524912A1 (en) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
KR20180095809A (ko) | 2015-11-11 | 2018-08-28 | 인사이클 세라퓨틱스, 인코포레이티드 | α4β7 인테그린을 표적으로 하는 고리형 펩타이드 |
EP3538542B1 (en) | 2016-11-11 | 2021-08-04 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha 4beta 7 integrin |
KR20230079464A (ko) | 2017-05-10 | 2023-06-07 | 질랜드 파마 에이/에스 | α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19731893A1 (de) * | 1997-07-25 | 1999-01-28 | Ivar Ugi | Neue Produkte der Passerini, der Ugi-4-Komponenten- und der Ugi-5-Zentren-4-Komponenten-Reaktion, Verfahren zu deren... |
CN1173946C (zh) * | 1998-01-29 | 2004-11-03 | 阿温蒂斯药物公司 | 制备n-[(脂族或芳族)羰基]-2-氨基乙酰胺化合物和环化化合物的方法 |
-
1999
- 1999-08-04 US US09/368,213 patent/US6492553B1/en not_active Expired - Lifetime
-
2000
- 2000-08-03 JP JP2001515272A patent/JP2003506420A/ja active Pending
- 2000-08-03 EP EP20000955355 patent/EP1212269B1/en not_active Expired - Lifetime
- 2000-08-03 WO PCT/US2000/021257 patent/WO2001010799A1/en active IP Right Grant
- 2000-08-03 DE DE60015371T patent/DE60015371T2/de not_active Expired - Lifetime
- 2000-08-03 AT AT00955355T patent/ATE280744T1/de not_active IP Right Cessation
- 2000-08-03 AU AU67574/00A patent/AU6757400A/en not_active Abandoned
- 2000-08-03 ES ES00955355T patent/ES2230143T3/es not_active Expired - Lifetime
-
2002
- 2002-11-15 HK HK02108269.5A patent/HK1046897B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2001010799A1 (en) | 2001-02-15 |
ATE280744T1 (de) | 2004-11-15 |
DE60015371D1 (de) | 2004-12-02 |
JP2003506420A (ja) | 2003-02-18 |
ES2230143T3 (es) | 2005-05-01 |
US6492553B1 (en) | 2002-12-10 |
EP1212269A1 (en) | 2002-06-12 |
HK1046897A1 (en) | 2003-01-30 |
DE60015371T2 (de) | 2005-12-29 |
EP1212269B1 (en) | 2004-10-27 |
AU6757400A (en) | 2001-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHPA | Change of a particular in the register (except of change of ownership) | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20080803 |