HK1036752A1 - Intramolecularly-quenched near infrared fluorescent probes - Google Patents

Intramolecularly-quenched near infrared fluorescent probes

Info

Publication number
HK1036752A1
HK1036752A1 HK01106083.4A HK01106083A HK1036752A1 HK 1036752 A1 HK1036752 A1 HK 1036752A1 HK 01106083 A HK01106083 A HK 01106083A HK 1036752 A1 HK1036752 A1 HK 1036752A1
Authority
HK
Hong Kong
Prior art keywords
intramolecularly
near infrared
fluorescent probes
infrared fluorescent
quenched near
Prior art date
Application number
HK01106083.4A
Other languages
English (en)
Inventor
Ralph Weissleder
Ching-Hsuan Tung
Umar Mahmood
Lee Josephson
Alexei Bogdanov
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of HK1036752A1 publication Critical patent/HK1036752A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Surface Treatment Of Glass (AREA)
  • Polyesters Or Polycarbonates (AREA)
HK01106083.4A 1998-05-14 2001-08-28 Intramolecularly-quenched near infrared fluorescent probes HK1036752A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/079,447 US6083486A (en) 1998-05-14 1998-05-14 Intramolecularly-quenched near infrared fluorescent probes
PCT/US1999/010589 WO1999058161A1 (fr) 1998-05-14 1999-05-13 Sondes fluorescentes en proche infrarouge a extension intramoleculaire

Publications (1)

Publication Number Publication Date
HK1036752A1 true HK1036752A1 (en) 2002-01-18

Family

ID=22150620

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01106083.4A HK1036752A1 (en) 1998-05-14 2001-08-28 Intramolecularly-quenched near infrared fluorescent probes

Country Status (9)

Country Link
US (1) US6083486A (fr)
EP (2) EP2251041A3 (fr)
JP (2) JP4726297B2 (fr)
AT (1) ATE473017T1 (fr)
AU (1) AU770216B2 (fr)
CA (1) CA2328136C (fr)
DE (1) DE69942563D1 (fr)
HK (1) HK1036752A1 (fr)
WO (1) WO1999058161A1 (fr)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7107116B2 (en) * 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
EP1283728A2 (fr) * 2000-05-23 2003-02-19 Amersham Health AS Agents de contraste
GB0024351D0 (en) * 2000-10-04 2000-11-22 Amersham Pharm Biotech Uk Ltd Dye-labelled peptide and method
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1379284A4 (fr) * 2001-01-05 2007-07-25 Gen Hospital Sondes d'imagerie activables
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
GB2372256A (en) * 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
DE10151670A1 (de) * 2001-10-19 2003-05-08 Siemens Ag Bildgebungsverfahren und Bildgebungsvorrichtung, insbesondere für die Kleintierbildgebung
EP1469989B1 (fr) * 2002-01-02 2011-12-14 Visen Medical, Inc. Nanoparticules superparamagnetiques a fonctionnalisation amine pour la synthese de conjugues biologiques
WO2003061711A2 (fr) * 2002-01-16 2003-07-31 Visen Medical, Inc. Sondes chromophores pour imagerie optique
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
US20050249668A1 (en) * 2002-03-29 2005-11-10 Ralph Weissleder Nir-fluorescent cyanine dyes, their synthesis and biological use
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
EP1481633B1 (fr) * 2003-05-30 2007-05-02 Siemens Aktiengesellschaft Dispositif pour la détection d'une substance du métabolisme d'un être vivant
WO2004108902A2 (fr) * 2003-06-04 2004-12-16 Visen Medical, Inc. Nanoparticles de silicium fluorescentes biocompatibles
EP1635878B1 (fr) * 2003-06-25 2010-12-29 Guerbet CONJUGUES PEPTIDIQUES POUR IMAGERIE DES Métalloprotéinase matricielle PAR RESONANCE MAGNETIQUE
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US7985401B2 (en) 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
US20050272967A1 (en) * 2004-05-18 2005-12-08 Siemens Aktiengesellschaft Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams
EP1747026A1 (fr) * 2004-05-18 2007-01-31 Siemens Aktiengesellschaft Agents de contraste biomoleculaires de controle therapeutique dans une radiotherapie avec faisceau d'ions ou de protons
US20050259779A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams
US7585492B2 (en) 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
JP2006225270A (ja) * 2005-02-15 2006-08-31 Yoshihiro Futamura 性ホルモン修飾作用を有するトリペプチド又はそれを含有する抽出物、エイコサペンタエン酸を結合してなるトリペプチド、それからなる食品製剤、化粧品製剤、子宮内膜症治療剤
US20090209508A1 (en) * 2005-05-16 2009-08-20 Universite De Geneve Compounds for Photochemotherapy
AU2006266074A1 (en) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
EP1934202B1 (fr) 2005-09-02 2019-01-09 Visen Medical, Inc. Fluorophores proches infrarouge derives d'acide nicotinique et d'acide picolinique
CA2621137C (fr) * 2005-09-02 2014-07-29 Visen Medical, Inc. Marqueurs colorants fluorescents contenant du sulfamide n,n-disubstitue biocompatible
EP1937676B1 (fr) * 2005-09-02 2016-11-30 Visen Medical, Inc. Agents d'imagerie fluorescentes biocompatibles
EP1973575B1 (fr) 2005-12-22 2019-07-24 Visen Medical, Inc. Nanoparticules d'oxyde métallique fluorescentes biocompatibles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
US8478386B2 (en) 2006-01-10 2013-07-02 Accuvein Inc. Practitioner-mounted micro vein enhancer
US12089951B2 (en) 2006-01-10 2024-09-17 AccuVeiw, Inc. Scanned laser vein contrast enhancer with scanning correlated to target distance
US10813588B2 (en) 2006-01-10 2020-10-27 Accuvein, Inc. Micro vein enhancer
US8489178B2 (en) 2006-06-29 2013-07-16 Accuvein Inc. Enhanced laser vein contrast enhancer with projection of analyzed vein data
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
US9492117B2 (en) 2006-01-10 2016-11-15 Accuvein, Inc. Practitioner-mounted micro vein enhancer
US11253198B2 (en) 2006-01-10 2022-02-22 Accuvein, Inc. Stand-mounted scanned laser vein contrast enhancer
US9854977B2 (en) 2006-01-10 2018-01-02 Accuvein, Inc. Scanned laser vein contrast enhancer using a single laser, and modulation circuitry
US11278240B2 (en) 2006-01-10 2022-03-22 Accuvein, Inc. Trigger-actuated laser vein contrast enhancer
US10238294B2 (en) 2006-06-29 2019-03-26 Accuvein, Inc. Scanned laser vein contrast enhancer using one laser
US8463364B2 (en) 2009-07-22 2013-06-11 Accuvein Inc. Vein scanner
US8594770B2 (en) 2006-06-29 2013-11-26 Accuvein, Inc. Multispectral detection and presentation of an object's characteristics
US8730321B2 (en) 2007-06-28 2014-05-20 Accuvein, Inc. Automatic alignment of a contrast enhancement system
US8078264B2 (en) 2006-07-11 2011-12-13 Case Western Reserve University Intra-operative molecular imaging
JP5864077B2 (ja) 2006-09-08 2016-02-17 ロード アイランド ホスピタル アルコール誘発性肝疾患の治療、予防および回復
US9308198B2 (en) 2006-09-08 2016-04-12 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced brain disease
JP2010507645A (ja) * 2006-10-25 2010-03-11 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 前立腺癌を検出するための造影剤
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
ES2670852T3 (es) * 2007-02-09 2018-06-01 Visen Medical, Inc. Colorantes con policiclo y uso de los mismos
JP2010519320A (ja) 2007-02-28 2010-06-03 サノフィ−アベンティス イメージングプローブ
WO2008109832A2 (fr) * 2007-03-08 2008-09-12 Visen Medical, Inc. Cellules viables marquées par un fluorochrome proche infrarouge et leurs procédés de préparation et d'utilisation
US9271653B2 (en) 2007-06-12 2016-03-01 Case Western Reserve University Intra-operative molecular imaging
US7906106B2 (en) 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
CN101772577A (zh) 2007-08-03 2010-07-07 塞诺菲-安万特股份有限公司 半胱天冬蛋白酶成像探针
JP5448397B2 (ja) * 2007-09-07 2014-03-19 キヤノン株式会社 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
EP3320923B1 (fr) 2008-01-18 2022-04-06 Visen Medical, Inc. Agents d'imagerie fluorescente
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
AU2009246822B2 (en) * 2008-03-31 2012-05-03 University Of Louisville Research Foundation, Inc. Site specific fluorescence marking and contrast marker for same
JP5278873B2 (ja) * 2008-05-14 2013-09-04 国立大学法人九州工業大学 癌診断用試薬
WO2010042815A2 (fr) * 2008-10-09 2010-04-15 Duke University Fragments d'anticorps vhh utilisables dans le cadre de la détection et du traitement du cancer
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
GB0823315D0 (en) * 2008-12-22 2009-01-28 Ge Healthcare As Fluorescent Probes
KR101043407B1 (ko) * 2009-02-19 2011-06-22 한국과학기술연구원 암 표적성이 우수한 단백질 복합체 및 이의 제조방법
EP2435096A1 (fr) * 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Procédés et systèmes destinés à identifier de manière spatiale des cellules anormales
US9155471B2 (en) * 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US9682151B2 (en) 2009-07-15 2017-06-20 The Regents Of The University Of California Peptides whose uptake in cells is controllable
US9061109B2 (en) 2009-07-22 2015-06-23 Accuvein, Inc. Vein scanner with user interface
SG177763A1 (en) 2009-07-28 2012-03-29 Hoffmann La Roche Non-invasive in vivo optical imaging method
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
BR112012028006A2 (pt) 2010-05-07 2016-08-02 Hoffmann La Roche método de imuno-histoquímica (ihq), uso de um domínio de ligação, kit e domínio de ligação terapeuticamente ativo
EP2609935B1 (fr) * 2010-08-23 2018-10-10 Shimadzu Corporation Sonde de type nanoparticule fluorescente à commutation et procédé d'imagerie utilisant des particules fluorescentes l'utilisant
EP2633080B1 (fr) 2010-10-29 2018-12-05 President and Fellows of Harvard College Procédé pour la detection des molecules cibles utilisant des sondes à nanotubes d'acide nucléique marquées de façon fluorescente
US9265844B2 (en) 2010-12-01 2016-02-23 The Methodist Hospital System Protease degradable polypeptides and uses thereof
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
WO2012118136A1 (fr) * 2011-03-02 2012-09-07 国立大学法人京都大学 Sonde de nanoparticules fluorescentes de type à commutation, et procédé d'imagerie moléculaire de fluorescence l'utilisant
JP6100704B2 (ja) 2011-03-07 2017-03-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 治療用抗体についてのインビボ試験の手段および方法
EP2683413A1 (fr) 2011-03-07 2014-01-15 F.Hoffmann-La Roche Ag Sélection in vivo d'anticorps actifs thérapeutiquement
JP6122840B2 (ja) 2011-05-09 2017-04-26 ビセン メディカル， インコーポレイテッド 炭酸脱水酵素標的化剤およびそれの使用方法
WO2012159107A1 (fr) 2011-05-19 2012-11-22 Rhode Island Hospital Inhibition d'une fibrose rénale
US20150031046A1 (en) * 2011-05-24 2015-01-29 Lijun Dai Bioanalytical Reagent used in Heterogeneous Phase and Usage Method Thereof
KR102004558B1 (ko) 2011-07-29 2019-07-26 아벨라스 바이오사이언시즈 인코포레이티드 선택적 전달 분자 및 사용 방법
JPWO2013081036A1 (ja) * 2011-11-29 2015-04-27 太陽誘電株式会社 マーカ分子
US9375493B2 (en) 2012-03-30 2016-06-28 Visen Medical, Inc. Bacterial imaging agents and methods of using same
US9072426B2 (en) 2012-08-02 2015-07-07 AccuVein, Inc Device for detecting and illuminating vasculature using an FPGA
CN104955484B (zh) 2012-08-15 2019-01-15 文森医学公司 用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法
US20150258217A1 (en) * 2012-10-04 2015-09-17 The General Hospital Corporation Methods of Synthesizing and Using Peg-Like Fluorochromes
US9650674B2 (en) 2012-10-19 2017-05-16 Bioventures, Llc Nucleic acid probes and methods of using the same
US10548962B2 (en) 2012-10-22 2020-02-04 The Board Of Regents For Oklahoma State University Use of the salmonella SPP type III secretion proteins as a protective vaccination
US9950053B2 (en) 2012-10-22 2018-04-24 The Board Of Regents For Oklahoma State University Use of the Salmonella SPP type III secretion proteins as a protective vaccination
US10517483B2 (en) 2012-12-05 2019-12-31 Accuvein, Inc. System for detecting fluorescence and projecting a representative image
NL2010040C2 (en) * 2012-12-21 2014-06-24 Internat Inst For Diagnostic And Analitical Affairs B V Cleavable coating material having microbial functionality.
WO2014120837A2 (fr) 2013-01-29 2014-08-07 The Regents Of The University Of California Peptide à pénétration cellulaire activable pré-ciblé comportant un promédicament à libération intracellulaire
KR102363779B1 (ko) 2013-01-30 2022-02-15 아벨라스 바이오사이언시즈 인코포레이티드 선택적 전달 분자 및 사용 방법
US9439976B2 (en) 2013-02-13 2016-09-13 The Methodist Hospital System Compositions and methods for using cathepsin E cleavable substrates
JP6478971B2 (ja) 2013-03-14 2019-03-06 ルミセル, インコーポレーテッドLumicell, Inc. 医用撮像装置
WO2014160037A2 (fr) 2013-03-14 2014-10-02 The Regents Of The University Of California Peptides d'interaction ayant une membrane activables et leurs procédés d'utilisation
CA2901379C (fr) 2013-03-15 2023-05-16 Visen Medical, Inc. Fluorochromes rouge a proche-infrarouge a base d'un silaxanthenium substitue pour l'imagerie et la detection in vitro et in vivo
CA2901000C (fr) 2013-03-15 2023-03-14 Visen Medical, Inc. Colorants d'heptamethine cyanine pontee par cyclohexyle 4,4-disubstitue et leurs utilisations
AU2014296253A1 (en) 2013-07-30 2016-02-04 President And Fellows Of Harvard College Quantitative DNA-based imaging and super-resolution imaging
EP3027228B1 (fr) * 2013-08-01 2024-10-02 Rochester Institute of Technology Agents modulaires d'imagerie contenant des acides aminés et des peptides
EP2848696A1 (fr) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Sondes d'imagerie de caspase 1
CN104673274A (zh) * 2013-12-02 2015-06-03 复旦大学 一种用于肿瘤转移倾向评估的靶向示踪的酸敏感近红外荧光探针
EP3088898B1 (fr) 2013-12-27 2024-02-07 National University Corporation Tokyo Medical and Dental University Procédé pour le diagnostic de la maladie d'alzheimer et de la dégénérescence lobaire frontotemporale, agent diagnostique, agent thérapeutique, et procédé de dépistage utilisant lesdits agents
KR102313982B1 (ko) 2014-03-11 2021-10-18 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로그램가능한 핵산 프로브를 이용한 고처리량 고도 다중 영상화
ES2830392T3 (es) 2014-07-23 2021-06-03 Ohio State Innovation Foundation Métodos y composiciones relacionados con fragmentos de anticuerpo que se unen a la glicoproteína 72 asociada a tumores (TAG-72)
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
NL2013786B1 (en) * 2014-11-13 2016-10-07 Original G B V Quenched coating.
US10596259B2 (en) 2015-05-20 2020-03-24 The Regents Of The University Of California Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
US20180224461A1 (en) 2015-08-07 2018-08-09 President And Fellows Of Harvard College Super resolution imaging of protein-protein interactions
CN106280533B (zh) * 2016-08-17 2018-03-09 赣南师范大学 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记
AU2017370751B2 (en) 2016-12-09 2023-11-09 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
JP6977287B2 (ja) * 2017-03-29 2021-12-08 東ソー株式会社 複数の蛍光物質を用いた標識方法
PL3630742T3 (pl) * 2017-05-24 2024-04-08 Ramot At Tel-Aviv University Ltd. Sondy chemiluminescencyjne do obrazowania/wykrywania proteaz
AU2019217628B2 (en) * 2018-02-06 2024-09-05 Gen-Probe Incorporated Far-red dye probe formulations
CN111704716B (zh) * 2020-07-03 2021-07-13 浙江大学 一种荧光聚赖氨酸树枝状大分子、其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636562B2 (en) * 1986-12-15 1993-05-06 British Technology Group Usa, Inc. Monomeric phthalocyanine reagents
US5384241A (en) * 1987-09-11 1995-01-24 Enzo Diagnostics, Inc. Specific binding assay compound with inhibitive self-quenching characteristics
EP0434858B1 (fr) * 1989-12-27 1994-02-23 Societe Des Produits Nestle S.A. Produit de réaction d'un dextranomère greffé et d'un colorant phthalocyanine et son utilisation
US5403928A (en) * 1990-05-15 1995-04-04 Diatron Corporation Fluorescent marker components and fluorescent probes
US5641878A (en) * 1991-05-15 1997-06-24 Diatron Corporation Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding
CA2082934C (fr) * 1990-05-15 2003-08-05 Walter B. Dandliker Phthalocyanatopolyethyleneglycol, et phthalocyanatosaccharides utilises comme reactifs fluorescents de type digoxine
CA2082936C (fr) * 1990-05-15 2003-09-23 Peter O. G. Arrhenius Porphyrine fluorescente, et derives fluorescents phthalocyaninepolyethylene-glycol, -polyol, et -saccharide utilises comme sondes fluorescentes
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
AU5085793A (en) * 1992-09-04 1994-03-29 General Hospital Corporation, The Biocompatible polymers containing diagnostic or therapeutic moieties
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay

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EP1077731B1 (fr) 2010-07-07
JP5171970B2 (ja) 2013-03-27
US6083486A (en) 2000-07-04
WO1999058161A1 (fr) 1999-11-18
CA2328136A1 (fr) 1999-11-18
DE69942563D1 (de) 2010-08-19
CA2328136C (fr) 2009-03-24
AU4077799A (en) 1999-11-29
JP2002514610A (ja) 2002-05-21
AU770216B2 (en) 2004-02-19
ATE473017T1 (de) 2010-07-15
EP1077731A4 (fr) 2004-05-12
EP2251041A3 (fr) 2010-12-01
EP1077731A1 (fr) 2001-02-28
JP4726297B2 (ja) 2011-07-20
EP2251041A2 (fr) 2010-11-17
JP2011095273A (ja) 2011-05-12

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