HK1035133A1 - Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor - Google Patents

Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor

Info

Publication number
HK1035133A1
HK1035133A1 HK01105503.8A HK01105503A HK1035133A1 HK 1035133 A1 HK1035133 A1 HK 1035133A1 HK 01105503 A HK01105503 A HK 01105503A HK 1035133 A1 HK1035133 A1 HK 1035133A1
Authority
HK
Hong Kong
Prior art keywords
differentiation
hedgehog
tissue growth
inhibiting cell
uses therefor
Prior art date
Application number
HK01105503.8A
Other languages
English (en)
Inventor
Linda Burkly
Li Chun Wang
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of HK1035133A1 publication Critical patent/HK1035133A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK01105503.8A 1998-09-11 2001-08-29 Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor HK1035133A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10003798P 1998-09-11 1998-09-11
PCT/US1999/020852 WO2000018428A2 (en) 1998-09-11 1999-09-10 Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor

Publications (1)

Publication Number Publication Date
HK1035133A1 true HK1035133A1 (en) 2001-11-16

Family

ID=22277802

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01105503.8A HK1035133A1 (en) 1998-09-11 2001-08-29 Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor

Country Status (8)

Country Link
US (1) US7445778B2 (de)
EP (1) EP1112087B1 (de)
AT (1) ATE458497T1 (de)
AU (1) AU773044B2 (de)
CA (1) CA2343335C (de)
DE (1) DE69942063D1 (de)
HK (1) HK1035133A1 (de)
WO (1) WO2000018428A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE449836T1 (de) * 1997-02-10 2009-12-15 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
WO2000015246A2 (en) 1998-09-11 2000-03-23 President And Fellows Of Harvard College Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6159950A (en) * 1998-10-16 2000-12-12 Cornell Research Foundation, Inc. Method of modulating hair growth
DE69939327D1 (de) * 1998-11-02 2008-09-25 Curis Inc Funktionelle antagonisten von hedgehog-aktivität
DE60016402T2 (de) * 1999-06-08 2005-10-27 Lorantis Ltd. Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
US8168178B2 (en) * 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
JP4954426B2 (ja) * 2000-06-16 2012-06-13 キュリス，インコーポレイテッド 血管形成調節組成物及び利用
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
DK1387674T3 (en) * 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
ES2707393T3 (es) 2004-03-26 2019-04-03 Curis Inc Moduladores de interferencia de ARN de señalización de hedgehog y usos de los mismos
US20060057088A1 (en) * 2004-09-16 2006-03-16 Nikolai Tankovich Vaccine for hair removal
WO2008063563A2 (en) * 2006-11-16 2008-05-29 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mtor inhibitors
WO2009126840A1 (en) * 2008-04-11 2009-10-15 Galaxy Biotech, Llc Combination of hgf inhibitor and hedgehog inhibitor to treat cancer
DK2948134T3 (da) 2013-01-24 2020-06-02 Palvella Therapeutics Inc Sammensætninger til transdermal indgivelse af mtor-inhibitorer
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物およびその使用方法
US10419468B2 (en) * 2017-07-11 2019-09-17 The Boeing Company Cyber security system with adaptive machine learning features
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
WO1993019177A1 (en) 1992-03-18 1993-09-30 The General Hospital Corporation FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY
US6610656B1 (en) 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6261786B1 (en) 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6165747A (en) 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6884775B1 (en) 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6384192B1 (en) 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
AU704178B2 (en) 1993-12-30 1999-04-15 Imperial Cancer Research Technology Ltd Vertebrate embryonic pattern-inducing hedgehog-like proteins
JPH09509574A (ja) 1994-02-25 1997-09-30 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 脊索によって発現されるヘッジホッグ、Ｖｈｈ−１、の脊椎動物相同体をコードするＤＮＡ、及びこれらの使用
US6027882A (en) 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
US6429354B1 (en) 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
US6946257B1 (en) 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto
EP0804548B1 (de) 1994-10-07 2005-07-13 The Board Of Trustees Of The Leland Stanford Junior University Ptc gene und ihre verwendung
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5759811A (en) 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
DK1387674T3 (en) 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto

Also Published As

Publication number Publication date
US20020015702A1 (en) 2002-02-07
EP1112087B1 (de) 2010-02-24
DE69942063D1 (de) 2010-04-08
ATE458497T1 (de) 2010-03-15
CA2343335A1 (en) 2000-04-06
US7445778B2 (en) 2008-11-04
AU773044B2 (en) 2004-05-13
WO2000018428A2 (en) 2000-04-06
EP1112087A2 (de) 2001-07-04
WO2000018428A3 (en) 2000-05-25
AU5918699A (en) 2000-04-17
CA2343335C (en) 2014-05-27

Similar Documents

Publication Publication Date Title
HK1035133A1 (en) Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
AU4025599A (en) Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases
DE69732444D1 (de) Vorrichtung für aktives Implantat
AU4713499A (en) Ophthalmic uses of ppargamma agonists and ppargamma antagonists
AU1126500A (en) Marker for indicating the location of identified tissue
EP1115389A4 (de) Antagonisten und agonisten der fructosamin oxidase
AU2455199A (en) Compositions and methods for regulated secretion from neuroendocrine cell lines
EP1192945A3 (de) Verwendung von einem Östrogen Agonist/Antagonist zur Behandlung von Osteoarthritis
HK1040076A1 (zh) 作為整聯蛋白抑制劑的喹嗪酮
GEP20094818B (en) 2-methyl-thieno-benzodiaze-pine formulation
EP0635263A3 (de) Angiotensin (AII)-antagonisten als Inhibitoren des Wachstums von Fettgewebe.
AU6003999A (en) Cathodic protection method and device for metal structure
ZA978494B (en) Method for inhibiting the growth of mammalian cells.
AU2333999A (en) Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors
AU4178497A (en) HTm4, methods of treatment and assays, agonists and antagonists
EP0979892A3 (de) Aufsetzvorrichtung einer Flachstrickmaschine und damit verwendetes Aufsetzverfahren
ZA992192B (en) Humectant and lubricant solution for ophthalmic use.
AU2958099A (en) Method for searching steroid sulfatase inhibitors
AU2645399A (en) Electrochemical capacitor and method for making the same
IL137439A0 (en) Method for the determination of prosthetic infections
EP1103814A4 (de) Verfahren zum bestimmen von physiologisch aktiven komponenten
PL352997A1 (en) Epithelial cell growth inhibitors
GB9814801D0 (en) Integrin dependent cell adhesion inhibitors
AU8680998A (en) Method for preventing or treating erectile dysfunction by administering an endothelin antagonist
AU6465800A (en) Systems and methods for accumulating and consolidating bonus points

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20160910