HK1033582A1 - Antibodies to death receptor 4 (dr4) and uses thereof - Google Patents
Antibodies to death receptor 4 (dr4) and uses thereofInfo
- Publication number
- HK1033582A1 HK1033582A1 HK01103340.0A HK01103340A HK1033582A1 HK 1033582 A1 HK1033582 A1 HK 1033582A1 HK 01103340 A HK01103340 A HK 01103340A HK 1033582 A1 HK1033582 A1 HK 1033582A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibodies
- death receptor
- kits
- diagnosis
- articles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7248198P | 1998-01-26 | 1998-01-26 | |
PCT/US1999/001437 WO1999037684A1 (fr) | 1998-01-26 | 1999-01-25 | Anticorps du recepteur 4 de la mort cellulaire (dr4) et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1033582A1 true HK1033582A1 (en) | 2001-09-07 |
Family
ID=22107878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK01103340.0A HK1033582A1 (en) | 1998-01-26 | 2001-05-14 | Antibodies to death receptor 4 (dr4) and uses thereof |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1053256B9 (fr) |
JP (1) | JP2002500877A (fr) |
AT (1) | ATE517125T1 (fr) |
AU (1) | AU2338299A (fr) |
CA (1) | CA2318405C (fr) |
CY (1) | CY1111863T1 (fr) |
DK (1) | DK1053256T3 (fr) |
ES (1) | ES2368823T3 (fr) |
HK (1) | HK1033582A1 (fr) |
IL (1) | IL137176A0 (fr) |
PT (1) | PT1053256E (fr) |
WO (1) | WO1999037684A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
US8329179B2 (en) | 1997-01-28 | 2012-12-11 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
US7452538B2 (en) | 1997-01-28 | 2008-11-18 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
WO1998032856A1 (fr) | 1997-01-28 | 1998-07-30 | Human Genome Sciences, Inc. | Recepteur 4 (dr4-recepteur 4 de mort cellulaire) contenant des domaines de mort cellulaire, membre de la superfamille du recepteur du facteur de necrose tumorale (tnf) et se liant a la queue (apo2-l) |
CA2373063A1 (fr) * | 1999-05-06 | 2000-11-16 | Jian Ni | Recepteur 4 contenant le domaine de la mort cellulaire programmee |
DE60042066D1 (de) * | 1999-05-28 | 2009-06-04 | Genentech Inc | Chimärische dr4 antikörper und ihre verwendung |
EP1658859A1 (fr) * | 1999-06-09 | 2006-05-24 | Genentech, Inc. | Synergie des agonistes du récepteur APO-2L et du CPT-11 |
WO2000075191A2 (fr) * | 1999-06-09 | 2000-12-14 | Genentech, Inc. | Synergie d'agoniste des recepteurs de ligand apo-2 (apo-2l) et de cpt-11 |
DK2857516T3 (en) | 2000-04-11 | 2017-08-07 | Genentech Inc | Multivalent antibodies and uses thereof |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
JP2004509078A (ja) * | 2000-07-27 | 2004-03-25 | ジェネンテック・インコーポレーテッド | Apo−2LレセプターアゴニストとCPT−11の相乗作用 |
WO2002079377A2 (fr) * | 2000-11-08 | 2002-10-10 | Human Genome Sciences, Inc. | Anticorps a liaison immunospecifique avec les recepteurs 'trail' |
JP3665316B2 (ja) | 2001-05-18 | 2005-06-29 | 麒麟麦酒株式会社 | 抗trail−r抗体 |
WO2002097033A2 (fr) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Anticorps se liant de maniere immunospecifique a des recepteurs de trail |
EP2192130A1 (fr) * | 2001-07-03 | 2010-06-02 | Genentech, Inc. | Anticorps DR4 humains et utilisations associées |
ES2357225T3 (es) * | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
CA2489348A1 (fr) | 2002-06-24 | 2003-12-31 | Genentech, Inc. | Variants du ligand apo-2/trail et utilisations de ceux-ci |
EP1534336A4 (fr) * | 2002-08-15 | 2005-12-14 | Human Genome Sciences Inc | Anticorps se fixant de facon immunospecifique a des recepteurs trail |
KR20120104408A (ko) | 2003-05-30 | 2012-09-20 | 제넨테크, 인크. | 항-vegf 항체를 사용한 치료 |
CN101061238B (zh) | 2004-08-06 | 2013-11-20 | 健泰科生物技术公司 | 使用生物标志的测定法和方法 |
JP5237638B2 (ja) | 2004-08-06 | 2013-07-17 | ジェネンテック, インコーポレイテッド | バイオマーカーを用いたアッセイおよび方法 |
AU2005282397A1 (en) * | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Methods of using death receptor ligands and CD20 antibodies |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
WO2006083937A2 (fr) | 2005-02-02 | 2006-08-10 | The Uab Research Foundation | Agents et methodes associes a la reduction de la resistance aux agonistes des recepteurs de mort induisant l'apoptose |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
ATE533058T1 (de) | 2005-08-16 | 2011-11-15 | Genentech Inc | Apoptosesensitivität gegenüber apo2l/trail mittels testen auf galnac-t14-expression in zellen/gewebe |
CN101074261A (zh) * | 2006-04-30 | 2007-11-21 | 北京同为时代生物技术有限公司 | Trail受体1和/或trail受体2特异性抗体及其应用 |
WO2008066854A2 (fr) * | 2006-11-28 | 2008-06-05 | Novartis Ag | Procédés et compositions induisant l'apoptose des cellules cancéreuses |
US20100105620A1 (en) | 2008-10-10 | 2010-04-29 | Anaphore, Inc. | Polypeptides that bind Trail-R1 and Trail-R2 |
US20140105898A1 (en) | 2011-02-28 | 2014-04-17 | Istituto Di Ricovero E Cura A Carattere Scientific Materno-Infantile Burlo Garo | Apoptosis-inducing molecules and uses therefor |
WO2012151317A1 (fr) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Agents d'interruption vasculaire et utilisations associées |
EP3323428A1 (fr) | 2016-11-17 | 2018-05-23 | CNRS Centre National de la Recherche Scientifique | Inhibiteurs sélectifs de c-flip en tant qu'agents anticancéreux |
CN115052888A (zh) | 2019-12-03 | 2022-09-13 | 上海交通大学医学院 | FcγRIIB亲和力增强的抗体Fc区 |
EP3910331A1 (fr) | 2020-05-15 | 2021-11-17 | iOmx Therapeutics AG | Kinase intracellulaire associée à une résistance contre la cytotoxicité médiée par des lymphocytes t et ses utilisations |
EP4257132A1 (fr) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Inhibiteurs de sik3 pour le traitement de maladies résistantes à la signalisation du récepteur de la mort |
WO2024175554A1 (fr) | 2023-02-21 | 2024-08-29 | Institut Curie | Agonistes de trail destinés à être utilisés dans le traitement du cancer chez des patients ayant une altération d'activation de fgfr3 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992015698A1 (fr) * | 1991-03-11 | 1992-09-17 | Sheila Drover | Anticorps monoclonaux murins reconnaissant des determinants polymorphes de l'antigene leucocytaire humain hla |
US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
SE9600820D0 (sv) * | 1996-03-01 | 1996-03-01 | Pharmacia Ab | Antibodies and their use |
ATE465257T1 (de) * | 1996-07-03 | 2010-05-15 | Genentech Inc | Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen |
CN1202247C (zh) * | 1996-07-12 | 2005-05-18 | 基因技术股份有限公司 | 嵌合异源多亚基粘附素 |
WO1998032856A1 (fr) | 1997-01-28 | 1998-07-30 | Human Genome Sciences, Inc. | Recepteur 4 (dr4-recepteur 4 de mort cellulaire) contenant des domaines de mort cellulaire, membre de la superfamille du recepteur du facteur de necrose tumorale (tnf) et se liant a la queue (apo2-l) |
-
1999
- 1999-01-25 WO PCT/US1999/001437 patent/WO1999037684A1/fr active Application Filing
- 1999-01-25 IL IL13717699A patent/IL137176A0/xx not_active IP Right Cessation
- 1999-01-25 ES ES99903332T patent/ES2368823T3/es not_active Expired - Lifetime
- 1999-01-25 JP JP2000528604A patent/JP2002500877A/ja active Pending
- 1999-01-25 EP EP99903332A patent/EP1053256B9/fr not_active Expired - Lifetime
- 1999-01-25 AU AU23382/99A patent/AU2338299A/en not_active Abandoned
- 1999-01-25 DK DK99903332.7T patent/DK1053256T3/da active
- 1999-01-25 PT PT99903332T patent/PT1053256E/pt unknown
- 1999-01-25 AT AT99903332T patent/ATE517125T1/de active
- 1999-01-25 CA CA2318405A patent/CA2318405C/fr not_active Expired - Lifetime
-
2001
- 2001-05-14 HK HK01103340.0A patent/HK1033582A1/xx not_active IP Right Cessation
-
2011
- 2011-09-27 CY CY20111100932T patent/CY1111863T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE517125T1 (de) | 2011-08-15 |
DK1053256T3 (da) | 2011-10-03 |
AU2338299A (en) | 1999-08-09 |
CA2318405C (fr) | 2014-01-07 |
CY1111863T1 (el) | 2015-11-04 |
ES2368823T3 (es) | 2011-11-22 |
EP1053256A1 (fr) | 2000-11-22 |
CA2318405A1 (fr) | 1999-07-29 |
EP1053256B1 (fr) | 2011-07-20 |
WO1999037684A1 (fr) | 1999-07-29 |
PT1053256E (pt) | 2011-09-28 |
JP2002500877A (ja) | 2002-01-15 |
IL137176A0 (en) | 2001-07-24 |
EP1053256B9 (fr) | 2012-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20190124 |