HK1023119A1 - Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases - Google Patents
Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseasesInfo
- Publication number
- HK1023119A1 HK1023119A1 HK00102254A HK00102254A HK1023119A1 HK 1023119 A1 HK1023119 A1 HK 1023119A1 HK 00102254 A HK00102254 A HK 00102254A HK 00102254 A HK00102254 A HK 00102254A HK 1023119 A1 HK1023119 A1 HK 1023119A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- pyrazole derivatives
- novel substituted
- substituted pyrazole
- cardiocirculatory diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19649460A DE19649460A1 (en) | 1996-11-26 | 1996-11-26 | New substituted pyrazole derivatives |
PCT/EP1997/006366 WO1998023619A1 (en) | 1996-11-26 | 1997-11-14 | Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1023119A1 true HK1023119A1 (en) | 2000-09-01 |
Family
ID=7813100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00102254A HK1023119A1 (en) | 1996-11-26 | 2000-04-13 | Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0944631B1 (en) |
JP (2) | JP4422800B2 (en) |
CN (1) | CN1122032C (en) |
AR (1) | AR010310A1 (en) |
AT (1) | ATE259812T1 (en) |
AU (1) | AU729642B2 (en) |
BR (1) | BR9714363A (en) |
CA (1) | CA2272584C (en) |
CZ (1) | CZ185099A3 (en) |
DE (2) | DE19649460A1 (en) |
DK (1) | DK0944631T3 (en) |
EE (1) | EE9900211A (en) |
ES (1) | ES2214646T3 (en) |
HK (1) | HK1023119A1 (en) |
HU (1) | HUP0000562A3 (en) |
ID (1) | ID21881A (en) |
IL (1) | IL129998A0 (en) |
MX (1) | MXPA99004826A (en) |
NO (1) | NO992400L (en) |
NZ (1) | NZ335890A (en) |
PT (1) | PT944631E (en) |
SK (1) | SK67699A3 (en) |
TR (1) | TR199901172T2 (en) |
TW (1) | TW403746B (en) |
WO (1) | WO1998023619A1 (en) |
ZA (1) | ZA9710573B (en) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19744026A1 (en) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazole derivatives, their preparation and their use in medicinal products |
DE19827679A1 (en) * | 1998-06-22 | 1999-12-23 | Dresden Arzneimittel | New pyrazolo(3,4-d)pyrimidine derivative adenosine A3 receptor antagonists, used for treating epilepsy, asthma or allergy |
DE19834047A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituted pyrazole derivatives |
DE19834044A1 (en) * | 1998-07-29 | 2000-02-03 | Bayer Ag | New substituted pyrazole derivatives |
DE19834045A1 (en) * | 1998-07-29 | 2000-02-03 | Bayer Ag | (4-Amino-5-ethylpyrimidin-2-yl) -1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine |
GB9824310D0 (en) * | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
DE19920352A1 (en) * | 1999-05-04 | 2000-11-09 | Bayer Ag | Substituted pyrazole derivative |
DE19943636A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943635A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE19943634A1 (en) | 1999-09-13 | 2001-04-12 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE10021069A1 (en) * | 2000-04-28 | 2001-10-31 | Bayer Ag | Substituted pyrazole derivative |
AR031176A1 (en) | 2000-11-22 | 2003-09-10 | Bayer Ag | NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE |
EP1339716B1 (en) | 2000-11-22 | 2004-11-03 | Bayer HealthCare AG | lactam-substituted pyrazolopyridine derivatives |
DE10057751A1 (en) | 2000-11-22 | 2002-05-23 | Bayer Ag | New carbamate-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation |
DE10057754A1 (en) | 2000-11-22 | 2002-05-23 | Bayer Ag | New cyclic sulfonamido-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation |
DE10109861A1 (en) | 2001-03-01 | 2002-09-05 | Bayer Ag | Novel side chain halogenated aminodicarboxylic acid derivatives |
DE10109858A1 (en) | 2001-03-01 | 2002-09-05 | Bayer Ag | Novel halogen-substituted aminodicarboxylic acid derivatives |
DE10110749A1 (en) * | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted aminodicarboxylic acid derivatives |
DE10122894A1 (en) | 2001-05-11 | 2002-11-14 | Bayer Ag | New pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl sulfonates, are soluble guanyl cyclase stimulants useful e.g. for treating cardiovascular, thromboembolic or central nervous system diseases |
DE10132416A1 (en) * | 2001-07-04 | 2003-01-16 | Bayer Ag | New morpholine-bridged pyrazolopyridine derivatives |
DE10220570A1 (en) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamate-substituted pyrazolopyridines |
DE10232572A1 (en) * | 2002-07-18 | 2004-02-05 | Bayer Ag | New 2,5-disubstituted pyrimidine derivatives |
DE10244810A1 (en) * | 2002-09-26 | 2004-04-08 | Bayer Ag | New morpholine-bridged indazole derivatives |
AU2004275694B2 (en) * | 2003-06-30 | 2008-03-06 | Bizbiotech Co., Ltd. | Compounds, compositions and methods |
DE102005050376A1 (en) | 2005-10-21 | 2007-05-31 | Bayer Healthcare Ag | Dicarboxylic acid derivatives and their use |
DE102005050377A1 (en) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Heterocyclic compounds and their use |
DE102005050375A1 (en) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Tetrazole derivatives and their use |
DE102005050498A1 (en) | 2005-10-21 | 2007-06-06 | Bayer Healthcare Aktiengesellschaft | Cyclopropylacetic acid derivatives and their use |
DE102005050497A1 (en) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Difluorophenol derivatives and their use |
DE102006020327A1 (en) * | 2006-04-27 | 2007-12-27 | Bayer Healthcare Ag | Heterocyclic substituted, fused pyrazole derivatives and their use |
DE102006043443A1 (en) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Novel aza-bicyclic compounds and their use |
DE102007015035A1 (en) | 2007-03-29 | 2008-10-02 | Bayer Healthcare Ag | Substituted dibenzoic acid derivatives and their use |
DE102007015034A1 (en) | 2007-03-29 | 2008-10-02 | Bayer Healthcare Ag | Lactam-substituted dicarboxylic acids and their use |
DE102007026392A1 (en) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Solutions for the perfusion and preservation of organs and tissues |
DE102007028320A1 (en) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituted oxazolidinones and their use |
DE102007028406A1 (en) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituted oxazolidinones and their use |
DE102007028407A1 (en) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituted oxazolidinones and their use |
DE102007028319A1 (en) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituted oxazolidinones and their use |
RU2531354C2 (en) | 2008-04-28 | 2014-10-20 | Янссен Фармацевтика Нв | Benzoimidazoles as prolyl hydroxylase inhibitors |
EP2138178A1 (en) | 2008-06-28 | 2009-12-30 | Bayer Schering Pharma Aktiengesellschaft | Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma |
DE102008063992A1 (en) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | New aliphatic substituted pyrazolopyridines and their use |
DE102009004245A1 (en) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Novel fused, heteroatom-bridged pyrazole and imidazole derivatives and their use |
UY33041A (en) | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | PROCEDURE FOR THE PREPARATION OF {4,6-DIAMINO-2- [1- (2-FLUOROBENCIL) -1H-PIRAZOLO [3,4-B] PIRIDIN-3-IL] PIRIMIDIN-5-IL} CARBAMATO DE METTILO AND ITS PURIFICATION FOR USE AS A PHARMACEUTICAL ACTIVE PRINCIPLE |
GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
BR112012033341B1 (en) | 2010-06-30 | 2022-08-23 | Cyclerion Therapeutics, Inc | SGC STIMULATORS |
JP5878546B2 (en) | 2010-11-09 | 2016-03-08 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC stimulant |
WO2012143510A1 (en) * | 2011-04-21 | 2012-10-26 | Bayer Intellectual Property Gmbh | Fluoroalkyl-substituted pyrazolopyridines and use thereof |
WO2013037411A1 (en) | 2011-09-14 | 2013-03-21 | Proximagen Limited | New enzyme inhibitor compounds |
US9139564B2 (en) | 2011-12-27 | 2015-09-22 | Ironwood Pharmaceuticals, Inc. | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators |
AU2013258043B2 (en) | 2012-05-10 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation factor XI and/or its activated form factor XIa and uses thereof |
WO2015106268A1 (en) | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
JP6748113B2 (en) | 2015-05-06 | 2020-08-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | Use of sGC stimulants, sGC activators alone or in combination with PDE5 inhibitors for treating digital ulcers (DU) associated with systemic sclerosis (SSc) |
SI3325013T2 (en) | 2015-07-23 | 2023-11-30 | Bayer Pharma Aktiengesellschaft | Stimulators / activators of soluble guanylat cyclase in combination with a nep-inhibitor and/or an angiotensin aii-antagonist and the use thereof |
WO2017106175A2 (en) | 2015-12-14 | 2017-06-22 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION |
WO2017121700A1 (en) * | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | 1,3-disubstituted 1h-pyrazolo[3,4-b]pyridine derivatives and use thereof as stimulators of soluble guanylate cyclase |
CN109890379A (en) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | Combination product comprising sGC activator and mineralocorticoid receptor antagonists |
CN110022871A (en) | 2016-10-11 | 2019-07-16 | 拜耳制药股份公司 | Combination product comprising sGC stimulant and mineralocorticoid receptor antagonists |
US20190381039A1 (en) | 2016-12-13 | 2019-12-19 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS |
KR102615821B1 (en) | 2017-04-11 | 2023-12-21 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Fluorine-substituted indazole compounds and uses thereof |
CN112384213A (en) | 2018-05-15 | 2021-02-19 | 拜耳公司 | 1, 3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
EP3820476A1 (en) | 2018-07-11 | 2021-05-19 | Cyclerion Therapeutics, Inc. | Use of sgc stimulators for the treatment of mitochonrial disorders |
WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0615542B2 (en) * | 1986-07-22 | 1994-03-02 | 吉富製薬株式会社 | Pyrazolopyridine compound |
US4994482A (en) * | 1989-07-31 | 1991-02-19 | Bristol-Myers Squibb Company | Arylpyrazol derivatives as anti-platelet agents, compositions and use |
WO1993023036A1 (en) * | 1992-05-21 | 1993-11-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Optically active condensed pyrazole compound for use in treating thrombocytopenia and erythropenia |
JP2928079B2 (en) * | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | 1- (Substituted benzyl) -3- (substituted aryl) condensed pyrazoles, their production and use |
CN1039536C (en) * | 1994-02-28 | 1998-08-19 | 永信药品工业股份有限公司 | 1,3 substituted condensed pyrazole compound, the application and prepn. method |
-
1996
- 1996-11-26 DE DE19649460A patent/DE19649460A1/en not_active Withdrawn
-
1997
- 1997-11-14 CN CN97180065A patent/CN1122032C/en not_active Expired - Fee Related
- 1997-11-14 TR TR1999/01172T patent/TR199901172T2/en unknown
- 1997-11-14 ES ES97951204T patent/ES2214646T3/en not_active Expired - Lifetime
- 1997-11-14 IL IL12999897A patent/IL129998A0/en unknown
- 1997-11-14 AT AT97951204T patent/ATE259812T1/en active
- 1997-11-14 AU AU54823/98A patent/AU729642B2/en not_active Ceased
- 1997-11-14 ID IDW990388A patent/ID21881A/en unknown
- 1997-11-14 DE DE59711321T patent/DE59711321D1/en not_active Expired - Lifetime
- 1997-11-14 SK SK676-99A patent/SK67699A3/en unknown
- 1997-11-14 JP JP52421898A patent/JP4422800B2/en not_active Expired - Fee Related
- 1997-11-14 EE EEP199900211A patent/EE9900211A/en unknown
- 1997-11-14 NZ NZ335890A patent/NZ335890A/en unknown
- 1997-11-14 HU HU0000562A patent/HUP0000562A3/en unknown
- 1997-11-14 DK DK97951204T patent/DK0944631T3/en active
- 1997-11-14 WO PCT/EP1997/006366 patent/WO1998023619A1/en not_active Application Discontinuation
- 1997-11-14 BR BR9714363A patent/BR9714363A/en active Search and Examination
- 1997-11-14 CZ CZ991850A patent/CZ185099A3/en unknown
- 1997-11-14 MX MXPA99004826A patent/MXPA99004826A/en not_active IP Right Cessation
- 1997-11-14 CA CA002272584A patent/CA2272584C/en not_active Expired - Fee Related
- 1997-11-14 PT PT97951204T patent/PT944631E/en unknown
- 1997-11-14 EP EP97951204A patent/EP0944631B1/en not_active Expired - Lifetime
- 1997-11-21 TW TW086117406A patent/TW403746B/en not_active IP Right Cessation
- 1997-11-25 ZA ZA9710573A patent/ZA9710573B/en unknown
- 1997-11-26 AR ARP970105563A patent/AR010310A1/en active IP Right Grant
-
1999
- 1999-05-19 NO NO992400A patent/NO992400L/en unknown
-
2000
- 2000-04-13 HK HK00102254A patent/HK1023119A1/en not_active IP Right Cessation
-
2009
- 2009-09-11 JP JP2009210476A patent/JP2010013475A/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
IL129998A0 (en) | 2000-02-29 |
HUP0000562A3 (en) | 2001-12-28 |
AR010310A1 (en) | 2000-06-07 |
CZ185099A3 (en) | 1999-08-11 |
DE19649460A1 (en) | 1998-05-28 |
JP2010013475A (en) | 2010-01-21 |
AU5482398A (en) | 1998-06-22 |
EP0944631A1 (en) | 1999-09-29 |
PT944631E (en) | 2004-06-30 |
TR199901172T2 (en) | 1999-08-23 |
DK0944631T3 (en) | 2004-06-07 |
EE9900211A (en) | 1999-12-15 |
CA2272584A1 (en) | 1998-06-04 |
WO1998023619A1 (en) | 1998-06-04 |
NO992400D0 (en) | 1999-05-19 |
JP2001505567A (en) | 2001-04-24 |
CN1238773A (en) | 1999-12-15 |
JP4422800B2 (en) | 2010-02-24 |
ES2214646T3 (en) | 2004-09-16 |
EP0944631B1 (en) | 2004-02-18 |
NO992400L (en) | 1999-05-19 |
DE59711321D1 (en) | 2004-03-25 |
MXPA99004826A (en) | 2008-02-19 |
ATE259812T1 (en) | 2004-03-15 |
AU729642B2 (en) | 2001-02-08 |
CN1122032C (en) | 2003-09-24 |
TW403746B (en) | 2000-09-01 |
CA2272584C (en) | 2007-10-16 |
HUP0000562A2 (en) | 2000-10-28 |
SK67699A3 (en) | 2000-02-14 |
ZA9710573B (en) | 1998-06-10 |
ID21881A (en) | 1999-08-05 |
NZ335890A (en) | 2001-02-23 |
BR9714363A (en) | 2000-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1023119A1 (en) | Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases | |
ZA983287B (en) | Substituted benzopyran derivatives for the treatment of inflammation | |
HK1009939A1 (en) | Medicament for treating cardiac inflammatory diseases | |
AU3548795A (en) | Benzopyranopyrazolyl derivatives for the treatment of inflammation | |
IL108772A0 (en) | Treatment of rhinitis by biostimulative illumination | |
HUP0102295A3 (en) | Benzamide derivatives for the treatment of diseases mediated by cytokines | |
HUP0102367A3 (en) | Benzamide derivatives for the treatment of diseases mediated by cytokines | |
PL315666A1 (en) | Heterocyclic compounds of therapeutic properties | |
AU2424895A (en) | Substituted spirodienes for the treatment of inflammation | |
IL129144A0 (en) | Use of 1-hydroxy-2-pyridones for the treatment of skin diseases | |
AU7310896A (en) | Use of nitroflavonoids for the treatment of anxiety | |
EP1039883A4 (en) | Methods for the treatment of apolipoprotein e related diseases | |
IL125002A0 (en) | Novel substituted 4-(1H-benzimidazol-2-yl) [1,4] diazepanes useful for the treatment of allergic diseases | |
NO991734D0 (en) | Pyrazolinones for the treatment of potency disorders | |
EP0790062A4 (en) | Remedy for heart diseases | |
GB9510162D0 (en) | Compositions for the treatment of skin conditions | |
AU2754997A (en) | The treatment of plant diseases | |
EP0783891A4 (en) | Remedy for bone diseases | |
IL130831A0 (en) | Imino-aza-anthracylinone derivatives for the treatment of amyloidosis | |
ZA944671B (en) | Medicaments for the treatment of inflammatory diseases | |
ZA97253B (en) | Topical compositions for the treatment of skin diseases | |
PL302380A1 (en) | Novel derivative of pyrimidobenzodiazepin | |
GB9515060D0 (en) | Therapeutic heterocyclic compounds | |
NO964631L (en) | Process for the preparation of essential bacteria-free colostrum | |
GB9710054D0 (en) | Treatment of diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20091114 |