HK1010729A1 - Itraconazole and saperconazole stereoisomers - Google Patents
Itraconazole and saperconazole stereoisomersInfo
- Publication number
- HK1010729A1 HK1010729A1 HK98111587A HK98111587A HK1010729A1 HK 1010729 A1 HK1010729 A1 HK 1010729A1 HK 98111587 A HK98111587 A HK 98111587A HK 98111587 A HK98111587 A HK 98111587A HK 1010729 A1 HK1010729 A1 HK 1010729A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- itraconazole
- saperconazole
- stereoisomers
- pharmaceutically acceptable
- stereoisomer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85364892A | 1992-03-18 | 1992-03-18 | |
PCT/EP1993/000552 WO1993019061A1 (en) | 1992-03-18 | 1993-03-10 | Itraconazole and saperconazole stereoisomers |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1010729A1 true HK1010729A1 (en) | 1999-06-25 |
Family
ID=25316567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98111587A HK1010729A1 (en) | 1992-03-18 | 1998-10-29 | Itraconazole and saperconazole stereoisomers |
Country Status (22)
Country | Link |
---|---|
US (1) | US5998413A (xx) |
EP (1) | EP0631578B1 (xx) |
KR (1) | KR100243534B1 (xx) |
AT (1) | ATE201408T1 (xx) |
AU (1) | AU665988B2 (xx) |
CA (1) | CA2117651C (xx) |
CZ (1) | CZ286619B6 (xx) |
DE (1) | DE69330248T2 (xx) |
DK (1) | DK0631578T3 (xx) |
ES (1) | ES2158859T3 (xx) |
FI (1) | FI113175B (xx) |
GR (1) | GR3036368T3 (xx) |
HK (1) | HK1010729A1 (xx) |
HU (1) | HU221189B1 (xx) |
NO (1) | NO307786B1 (xx) |
NZ (1) | NZ249494A (xx) |
PL (1) | PL172358B1 (xx) |
PT (1) | PT631578E (xx) |
RU (1) | RU2127733C1 (xx) |
SK (1) | SK283118B6 (xx) |
WO (1) | WO1993019061A1 (xx) |
ZA (1) | ZA931906B (xx) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994016700A1 (en) * | 1993-01-27 | 1994-08-04 | Sepracor, Inc. | Method and composition employing (2r,4s) itraconazole |
PH31594A (en) * | 1993-09-30 | 1998-11-03 | Janssen Pharmaceutica Nv | Oral formulations on an antifungal. |
US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
ES2112151B1 (es) * | 1995-03-17 | 1999-09-16 | Menarini Lab | Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos. |
WO1997039761A1 (en) | 1996-04-19 | 1997-10-30 | Alpha Therapeutic Corporation | A process for viral inactivation of lyophilized blood proteins |
EP0904060B1 (en) * | 1996-05-20 | 2003-12-10 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
AU5251398A (en) * | 1996-11-12 | 1998-06-03 | Sepracor, Inc. | (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole |
EP0942725A1 (en) * | 1996-11-12 | 1999-09-22 | Sepracor, Inc. | Use of cis-hydroxyitraconazole in order to avoid side-effects of itraconazole and hydroxyintraconazole |
US5952502A (en) * | 1996-11-12 | 1999-09-14 | Sepracor Inc. | 2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole |
WO1998021203A1 (en) * | 1996-11-12 | 1998-05-22 | Sepracor, Inc. | 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole |
CN1102592C (zh) * | 1996-11-12 | 2003-03-05 | 塞普拉科公司 | 2r,4s,s,s-和2s,4r,s,s-羟基伊曲康唑 |
ES2224364T3 (es) | 1997-02-11 | 2005-03-01 | Janssen Pharmaceutica N.V. | Azoles antifungicos que contienen esteres de aminoacidos. |
US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
EP0957101A1 (en) * | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
DE60023465T2 (de) | 1999-03-24 | 2006-07-20 | R.P. Scherer Technologies, Inc., Las Vegas | Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser |
KR100438485B1 (ko) * | 2001-08-13 | 2004-07-09 | 한국디디에스제약 주식회사 | 아졸류 항진균제의 약제학적 조성물 |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US7446107B2 (en) * | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
US20030224006A1 (en) | 2002-03-01 | 2003-12-04 | Zaworotko Michael J. | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
US7078526B2 (en) * | 2002-05-31 | 2006-07-18 | Transform Pharmaceuticals, Inc. | CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods |
US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
IL165383A0 (en) | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
KR100446256B1 (ko) * | 2002-07-11 | 2004-09-01 | 경동제약 주식회사 | 고 광학선택성을 가지는시스-2-(브로모메틸)-2-(2,4-디클로로페닐)-13-디옥소란-4-메틸알콜의 제조방법 |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
US20090028938A1 (en) | 2005-08-08 | 2009-01-29 | Abbott Gmbh & Co. Kg | Dosage forms with improved bioavailability |
US8486456B2 (en) | 2005-08-08 | 2013-07-16 | Abbott Gmbh & Co., Kg | Itraconazole compositions with improved bioavailability |
EP1919480B1 (en) | 2005-08-22 | 2013-01-16 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
US9072660B2 (en) | 2011-09-09 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Topical itraconazole formulations and uses thereof |
CN102379844A (zh) * | 2011-10-31 | 2012-03-21 | 广州维美投资有限公司 | 一种伊曲康唑异构体注射剂 |
CN105061411A (zh) * | 2015-06-23 | 2015-11-18 | 扬州艾迪生物科技有限公司 | 一种光学异构体2s,4r,2’s-伊曲康唑晶型及制备方法与应用 |
CN106146480B (zh) * | 2016-07-18 | 2019-08-06 | 山东罗欣药业集团恒欣药业有限公司 | 一种伊曲康唑的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
US4490530A (en) * | 1981-01-14 | 1984-12-25 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles |
GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
FR2622198B1 (fr) * | 1987-10-21 | 1992-04-30 | Mero Rousselot Satia | Compositions granulees de polysaccharides a dissolution aqueuse instantanee, procede pour leur preparation et utilisation |
US5017566A (en) * | 1987-12-30 | 1991-05-21 | University Of Florida | Redox systems for brain-targeted drug delivery |
US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
GB8908250D0 (en) * | 1989-04-12 | 1989-05-24 | Fisons Plc | Formulations |
US5214046A (en) * | 1989-07-27 | 1993-05-25 | Hoffmann-La Roche Inc. | Substituted aminoalkoxybenzene anti-fungicidal compositions and use |
WO1994016700A1 (en) * | 1993-01-27 | 1994-08-04 | Sepracor, Inc. | Method and composition employing (2r,4s) itraconazole |
-
1993
- 1993-03-10 EP EP93905338A patent/EP0631578B1/en not_active Expired - Lifetime
- 1993-03-10 KR KR1019940702921A patent/KR100243534B1/ko not_active IP Right Cessation
- 1993-03-10 NZ NZ249494A patent/NZ249494A/en not_active IP Right Cessation
- 1993-03-10 DK DK93905338T patent/DK0631578T3/da active
- 1993-03-10 AT AT93905338T patent/ATE201408T1/de not_active IP Right Cessation
- 1993-03-10 DE DE69330248T patent/DE69330248T2/de not_active Expired - Fee Related
- 1993-03-10 HU HU9402656A patent/HU221189B1/hu not_active IP Right Cessation
- 1993-03-10 WO PCT/EP1993/000552 patent/WO1993019061A1/en active IP Right Grant
- 1993-03-10 PL PL93305223A patent/PL172358B1/pl not_active IP Right Cessation
- 1993-03-10 RU RU94045798A patent/RU2127733C1/ru not_active IP Right Cessation
- 1993-03-10 CA CA002117651A patent/CA2117651C/en not_active Expired - Fee Related
- 1993-03-10 SK SK1106-94A patent/SK283118B6/sk unknown
- 1993-03-10 ES ES93905338T patent/ES2158859T3/es not_active Expired - Lifetime
- 1993-03-10 PT PT93905338T patent/PT631578E/pt unknown
- 1993-03-10 AU AU36324/93A patent/AU665988B2/en not_active Ceased
- 1993-03-10 CZ CZ19942215A patent/CZ286619B6/cs not_active IP Right Cessation
- 1993-03-17 ZA ZA931906A patent/ZA931906B/xx unknown
-
1994
- 1994-09-16 NO NO943450A patent/NO307786B1/no unknown
- 1994-09-16 FI FI944311A patent/FI113175B/fi active
-
1996
- 1996-07-09 US US08/676,531 patent/US5998413A/en not_active Expired - Fee Related
-
1998
- 1998-10-29 HK HK98111587A patent/HK1010729A1/xx not_active IP Right Cessation
-
2001
- 2001-08-10 GR GR20010401224T patent/GR3036368T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU9402656D0 (en) | 1994-11-28 |
DK0631578T3 (da) | 2001-08-27 |
NO943450L (no) | 1994-11-11 |
KR950700904A (ko) | 1995-02-20 |
HUT71835A (en) | 1996-02-28 |
SK283118B6 (sk) | 2003-02-04 |
PT631578E (pt) | 2001-11-30 |
FI113175B (fi) | 2004-03-15 |
ES2158859T3 (es) | 2001-09-16 |
SK110694A3 (en) | 1995-04-12 |
FI944311A0 (fi) | 1994-09-16 |
EP0631578B1 (en) | 2001-05-23 |
NO307786B1 (no) | 2000-05-29 |
PL172358B1 (en) | 1997-09-30 |
ZA931906B (en) | 1994-09-17 |
DE69330248D1 (de) | 2001-06-28 |
DE69330248T2 (de) | 2002-03-21 |
ATE201408T1 (de) | 2001-06-15 |
NO943450D0 (no) | 1994-09-16 |
CA2117651C (en) | 2006-01-03 |
NZ249494A (en) | 1996-04-26 |
AU665988B2 (en) | 1996-01-25 |
HU221189B1 (en) | 2002-08-28 |
RU2127733C1 (ru) | 1999-03-20 |
AU3632493A (en) | 1993-10-21 |
GR3036368T3 (en) | 2001-11-30 |
RU94045798A (ru) | 1996-07-20 |
WO1993019061A1 (en) | 1993-09-30 |
KR100243534B1 (ko) | 2000-03-02 |
US5998413A (en) | 1999-12-07 |
CA2117651A1 (en) | 1993-09-30 |
CZ286619B6 (cs) | 2000-05-17 |
CZ221594A3 (en) | 1995-01-18 |
EP0631578A1 (en) | 1995-01-04 |
FI944311A (fi) | 1994-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20080310 |