GT200900282A - [4 (6-FLUORO-7-METHYLAMINE-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLINE-3-ILO) -PHENYLL] -5-CHLORINE-THIOPHEN-2-ILO SULFONYLIDE SALTS, AND FORMS AND METHODS RELATED TO THE SAME. - Google Patents

[4 (6-FLUORO-7-METHYLAMINE-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLINE-3-ILO) -PHENYLL] -5-CHLORINE-THIOPHEN-2-ILO SULFONYLIDE SALTS, AND FORMS AND METHODS RELATED TO THE SAME.

Info

Publication number
GT200900282A
GT200900282A GT200900282A GT200900282A GT200900282A GT 200900282 A GT200900282 A GT 200900282A GT 200900282 A GT200900282 A GT 200900282A GT 200900282 A GT200900282 A GT 200900282A GT 200900282 A GT200900282 A GT 200900282A
Authority
GT
Guatemala
Prior art keywords
ilo
sulfonylide
phenyll
thiophen
quinazoline
Prior art date
Application number
GT200900282A
Other languages
Spanish (es)
Inventor
Sharp Emma
Louisa Jane
Pandey Anjali
Wang Juan
Nieder Mathew
Huang Wolin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200900282A publication Critical patent/GT200900282A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE SULFONILUREA QUE SE HAN AISLADO COMO SOLIDOS CRISTALINOS DE ALTA PUREZA LOS CUALES SON DE UTILIDAD EN CUADROS DE TROMBOSIS LAS CUALES SON LA PRINCIPAL CAUSA DE MUERTE EN EL MUNDO INDUSTRIALIZADO.THE PRESENT INVENTION REFERS TO SULFONILUREA COMPOUNDS THAT HAVE BEEN ISOLATED AS HIGH PURITY CRYSTAL SOLIDS WHICH ARE USEFUL IN THROMBOSIS TABLES WHICH ARE THE MAIN CAUSE OF DEATH IN THE INDUSTRIALIZED WORLD.

GT200900282A 2007-05-02 2009-10-30 [4 (6-FLUORO-7-METHYLAMINE-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLINE-3-ILO) -PHENYLL] -5-CHLORINE-THIOPHEN-2-ILO SULFONYLIDE SALTS, AND FORMS AND METHODS RELATED TO THE SAME. GT200900282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92732807P 2007-05-02 2007-05-02

Publications (1)

Publication Number Publication Date
GT200900282A true GT200900282A (en) 2010-05-21

Family

ID=39651344

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900282A GT200900282A (en) 2007-05-02 2009-10-30 [4 (6-FLUORO-7-METHYLAMINE-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLINE-3-ILO) -PHENYLL] -5-CHLORINE-THIOPHEN-2-ILO SULFONYLIDE SALTS, AND FORMS AND METHODS RELATED TO THE SAME.

Country Status (18)

Country Link
US (1) US20090042916A1 (en)
EP (1) EP2076510A2 (en)
JP (1) JP2010526105A (en)
KR (1) KR20100020455A (en)
CN (1) CN101720324A (en)
AU (1) AU2008247457A1 (en)
BR (1) BRPI0810800A2 (en)
CA (1) CA2686221A1 (en)
CO (1) CO6241155A2 (en)
EA (1) EA200901474A1 (en)
EC (1) ECSP099779A (en)
GT (1) GT200900282A (en)
IL (1) IL201829A0 (en)
MA (1) MA31397B1 (en)
MX (1) MX2009011836A (en)
TN (1) TN2009000452A1 (en)
WO (1) WO2008137809A2 (en)
ZA (1) ZA200907493B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2627719C (en) * 2005-11-03 2016-07-12 Portola Pharmaceuticals, Inc. [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto
US20090156620A1 (en) * 2007-05-02 2009-06-18 Portola Pharmaceuticals, Inc. [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea salts, forms and methods related thereto
WO2011006169A1 (en) 2009-07-10 2011-01-13 Portola Pharmaceuticals, Inc. Methods for diagnosis and treatment of thrombotic disorders mediated by cyp2c19*2
US20130165459A1 (en) * 2010-01-12 2013-06-27 Norvartis Pharma Ag Pharmaceutical composition and dosage forms of elinogrel and methods of use thereof
WO2011137459A1 (en) 2010-04-30 2011-11-03 Portola Pharmaceuticals, Inc. Dosage forms of elinogrel and methods of injectable administration thereof
JP2013544271A (en) * 2010-12-03 2013-12-12 ポートラ ファーマシューティカルズ， インコーポレイテッド Pharmaceutical compositions, dosage forms and novel forms of compounds of formula (I) and methods of use thereof
CN106777526B (en) * 2016-11-25 2020-05-01 江苏大学 Genetic algorithm-based high-temperature high-pressure centrifugal impeller multidisciplinary optimization method
WO2019126557A1 (en) 2017-12-22 2019-06-27 Aesthetics Biomedical, Inc. Biologic preserving composition and methods of use
US10933096B2 (en) 2017-12-22 2021-03-02 Aesthetics Biomedical, Inc. Biologic preserving composition and methods of use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847925A (en) * 1971-07-15 1974-11-12 En Nom Collectif Science Et Ci Benzenesulfonyl semicarbazides
DE3134780A1 (en) * 1981-09-02 1983-03-10 Hoechst Ag, 6000 Frankfurt "SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE"
US4720450A (en) * 1985-06-03 1988-01-19 Polaroid Corporation Thermal imaging method
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
JP4574100B2 (en) * 2000-02-04 2010-11-04 ポートラ ファーマシューティカルズ， インコーポレイテッド Platelet ADP receptor inhibitor
US6906063B2 (en) * 2000-02-04 2005-06-14 Portola Pharmaceuticals, Inc. Platelet ADP receptor inhibitors
AU2002217999A1 (en) * 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
AU2003210477A1 (en) * 2002-01-09 2003-07-30 Enzrel, Inc. Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
US20040242658A1 (en) * 2003-01-08 2004-12-02 Dr. Reddy's Laboratories Limited Amorphous form of rosiglitazone maleate and process for preparation thereof
AU2004278030C1 (en) * 2003-10-03 2010-12-02 Portola Pharmaceuticals, Inc. 2,4-Dioxo-3-quinazolinylaryl sulfonylureas
CA2627719C (en) * 2005-11-03 2016-07-12 Portola Pharmaceuticals, Inc. [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto
AU2008247483A1 (en) * 2007-05-02 2008-11-13 Portola Pharmaceuticals, Inc. Intravenous and oral dosing of a direct-acting and reversible P2Y12 inhibitor
US20090156620A1 (en) * 2007-05-02 2009-06-18 Portola Pharmaceuticals, Inc. [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea salts, forms and methods related thereto

Also Published As

Publication number Publication date
MA31397B1 (en) 2010-05-03
TN2009000452A1 (en) 2011-03-31
BRPI0810800A2 (en) 2014-10-29
EP2076510A2 (en) 2009-07-08
CA2686221A1 (en) 2008-11-13
CN101720324A (en) 2010-06-02
US20090042916A1 (en) 2009-02-12
MX2009011836A (en) 2010-05-20
CO6241155A2 (en) 2011-01-20
WO2008137809A2 (en) 2008-11-13
EA200901474A1 (en) 2010-04-30
ECSP099779A (en) 2010-01-29
KR20100020455A (en) 2010-02-22
ZA200907493B (en) 2010-07-28
WO2008137809A3 (en) 2009-01-22
JP2010526105A (en) 2010-07-29
AU2008247457A1 (en) 2008-11-13
IL201829A0 (en) 2010-06-16

Similar Documents

Publication Publication Date Title
GT200900282A (en) [4 (6-FLUORO-7-METHYLAMINE-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLINE-3-ILO) -PHENYLL] -5-CHLORINE-THIOPHEN-2-ILO SULFONYLIDE SALTS, AND FORMS AND METHODS RELATED TO THE SAME.
UY29549A1 (en) NEW DERIVATIVES OF FLUORENE, COMPOSITIONS THAT CONTAIN THEM AND ITS USE
CR11130A (en) BENZOILAMINO-INDAN-2-SUBSTITUTED CARBOXILIC ACIDS AND RELATED COMPOUNDS
CR10662A (en) METHYLPIRIDOPIRIMIDINONE COMPOUNDS
DOP2011000174A (en) ORGANIC COMPOUNDS
UY31260A1 (en) PIRAZOL COMPOUNDS, COMPOSITIONS CONTAINING THEM AND APPLICATIONS.
CR9260A (en) BIS ARILO AND HETEROARILO SUBSTITUTED COMPOUNDS AS SELECTIVE ANTAGONISTS OF 5HT2a
CR20120031A (en) 5-FLUOROPIRIMIDINONE DERIVATIVES
SV2008002542A (en) SOLID CRYSTALLINE FORMS OF TIGECICLINE AND METHODS TO PREPARE THE SAME REF. 01142.0379-00267 (AM101946SV)
UY33469A (en) COMPOSITIONS AND METHODS TO MODULATE THE WNT SIGNALING ROAD
ECSP056063A (en) 6-RENT OR ALQUENIL-4-AMYNOPICOLINATES AND USE OF THE SAME AS HERBICIDES
NO20080129L (en) Process for the preparation of dihydroquinazolines
CO6741214A2 (en) Pesticide compositions and related processes
EA201070966A1 (en) FOLATES, COMPOSITIONS AND APPLICATIONS OF THE INDICATED COMPOSITIONS
CR20150254A (en) CHEMICAL COMPOUNDS
CR20140218A (en) COMPOUNDS OF REPLACED 1,2,5-OXADIAZOL AND ITS USE AS HERBICIDES III
ECSP10010058A (en) DERIVATIVES OF QUINAZOLINADIONA, ITS PREPARATION AND ITS THERAPEUTIC APPLICATIONS
UY30856A1 (en) NEW DERIVATIVES OF 2,4 DIANILINOPIRIMIDINAS, ITS PREPARATION, AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND MAINLY AS IKK INHIBITORS
CO2017003004A2 (en) New triazolo [4,5-d] pyrimidines
ECSP12011652A (en) DERIVATIVES OF 5-FLUORO-2-OXOPIRIMIDINONA-1 (2H) -CARBOXAMIDA SUBSTITUIDA-N1
CR11273A (en) DERIVADOS-2-ONA DISSTITUTED IN 3, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS
UY33794A (en) DIMERIC INHIBITORS OF THE IAP
UY33236A (en) DIMERIC INHIBITORS OF THE IAP
CR9966A (en) ACID 1- (1- (2-ETOXIETIL-3-ETIL-7- (4-METHYLPIRIDIN-2-ILAMINO) -1H-PIRAZOLO [4,3-D] PYRIMIDIN-5-IL) PIPERIDINE-4-CARBOXYL AND SALTS OF THE SAME.
GT200600048A (en) PIRROLES REPLACED, COMPOSITIONS THAT CONTAIN THEM, MANUFACTURING AND USE PROCESS.