GT199600101A - Derivados de octahidro-pirrolo (1,2,-a)-pirazina 2,7-sustituidos - Google Patents

Derivados de octahidro-pirrolo (1,2,-a)-pirazina 2,7-sustituidos

Info

Publication number
GT199600101A
GT199600101A GT199600101A GT199600101A GT199600101A GT 199600101 A GT199600101 A GT 199600101A GT 199600101 A GT199600101 A GT 199600101A GT 199600101 A GT199600101 A GT 199600101A GT 199600101 A GT199600101 A GT 199600101A
Authority
GT
Guatemala
Prior art keywords
pirazina
substituted
derivatives
octahidro
pirrolo
Prior art date
Application number
GT199600101A
Other languages
English (en)
Spanish (es)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199600101A publication Critical patent/GT199600101A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GT199600101A 1995-12-21 1996-12-19 Derivados de octahidro-pirrolo (1,2,-a)-pirazina 2,7-sustituidos GT199600101A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US898895P 1995-12-21 1995-12-21

Publications (1)

Publication Number Publication Date
GT199600101A true GT199600101A (es) 1998-06-12

Family

ID=21734893

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199600101A GT199600101A (es) 1995-12-21 1996-12-19 Derivados de octahidro-pirrolo (1,2,-a)-pirazina 2,7-sustituidos

Country Status (33)

Country Link
US (1) US5714487A (Direct)
EP (1) EP0874849B1 (Direct)
JP (1) JP3204456B2 (Direct)
KR (1) KR100286786B1 (Direct)
CN (1) CN1061350C (Direct)
AR (1) AR005102A1 (Direct)
AT (1) ATE205846T1 (Direct)
AU (1) AU704578B2 (Direct)
BR (1) BR9612246A (Direct)
CA (1) CA2240594C (Direct)
CO (1) CO4480107A1 (Direct)
CZ (1) CZ192998A3 (Direct)
DE (1) DE69615404T2 (Direct)
DK (1) DK0874849T3 (Direct)
ES (1) ES2161377T3 (Direct)
GR (1) GR3037060T3 (Direct)
GT (1) GT199600101A (Direct)
HU (1) HUP9900611A3 (Direct)
IL (1) IL124453A0 (Direct)
MA (1) MA26413A1 (Direct)
MX (1) MX9805088A (Direct)
NO (1) NO309936B1 (Direct)
NZ (1) NZ320537A (Direct)
PE (1) PE25998A1 (Direct)
PL (1) PL327539A1 (Direct)
PT (1) PT874849E (Direct)
RU (1) RU2162470C2 (Direct)
SI (1) SI0874849T1 (Direct)
TN (1) TNSN96164A1 (Direct)
TR (1) TR199801161T2 (Direct)
TW (1) TW479058B (Direct)
WO (1) WO1997023482A1 (Direct)
ZA (1) ZA9610781B (Direct)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
AU767089B2 (en) * 1999-02-05 2003-10-30 Pharmacia & Upjohn Company Process to prepare (5R)-(methylamino)-5,6-dihydro-4H- imidazo(4,5,1-ij)-quinolin-2(1H)-one
DE60011858T2 (de) 1999-09-10 2005-08-25 Mitsubishi Jidosha Kogyo K.K. Stufenloses Getriebe
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
MXPA02002694A (es) * 1999-09-14 2002-07-30 Aventis Pharm Prod Inc Derivados de benzisoxazolil-, piridoisoxazolil-y benzotienil-fenoxi utiles como antagonistas de d4.
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
AU2002331229B2 (en) * 2001-09-19 2008-05-15 Merck Patent Gmbh Novel use of substituted aminomethyl chromans
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2013049164A1 (en) * 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
AU2019336671B2 (en) * 2018-09-04 2025-06-05 Contineum Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
US5122515A (en) * 1990-06-19 1992-06-16 Smith Ross C Nutrient composition containing dipeptides and method for administering the same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
ES2133416T3 (es) * 1992-10-23 1999-09-16 Merck Sharp & Dohme Ligandos de subtipos de receptores de dopamina.
WO1996004250A1 (en) * 1994-08-05 1996-02-15 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
EP0783503B1 (en) * 1994-09-30 2001-11-28 Pfizer Inc. 2,7-substituted octahydro-1h-pyrido[ 1,2-a]pyrazine derivatives
US5576314A (en) * 1994-12-12 1996-11-19 Allelix Biopharmaceuticals Inc. Bicyclic nonane and decane compounds having dopamine receptor affinity

Also Published As

Publication number Publication date
PT874849E (pt) 2002-01-30
TW479058B (en) 2002-03-11
TNSN96164A1 (fr) 2005-03-15
US5714487A (en) 1998-02-03
ES2161377T3 (es) 2001-12-01
DE69615404T2 (de) 2002-06-06
CN1205704A (zh) 1999-01-20
CO4480107A1 (es) 1997-07-09
TR199801161T2 (xx) 1998-10-21
CZ192998A3 (cs) 1999-05-12
EP0874849B1 (en) 2001-09-19
DK0874849T3 (da) 2001-11-19
AU7328096A (en) 1997-07-17
NO309936B1 (no) 2001-04-23
CN1061350C (zh) 2001-01-31
IL124453A0 (en) 1998-12-06
NO982843D0 (no) 1998-06-19
ZA9610781B (en) 1998-06-22
SI0874849T1 (Direct) 2001-12-31
EP0874849A1 (en) 1998-11-04
BR9612246A (pt) 1999-07-13
NZ320537A (en) 1999-03-29
PL327539A1 (en) 1998-12-21
MA26413A1 (fr) 2004-12-20
NO982843L (no) 1998-06-19
KR100286786B1 (ko) 2001-04-16
WO1997023482A1 (en) 1997-07-03
DE69615404D1 (de) 2001-10-25
HUP9900611A3 (en) 2000-09-28
CA2240594A1 (en) 1997-07-03
CA2240594C (en) 2001-07-24
RU2162470C2 (ru) 2001-01-27
MX9805088A (es) 1998-10-31
KR19990076616A (ko) 1999-10-15
ATE205846T1 (de) 2001-10-15
JP3204456B2 (ja) 2001-09-04
PE25998A1 (es) 1998-05-19
AR005102A1 (es) 1999-04-14
HUP9900611A2 (hu) 1999-08-30
JPH11508920A (ja) 1999-08-03
AU704578B2 (en) 1999-04-29
GR3037060T3 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
GT199600101A (es) Derivados de octahidro-pirrolo (1,2,-a)-pirazina 2,7-sustituidos
ECSP055747A (es) Antagonistas de cgrp elegidos, procedimiento para su preparación, así como su empleo como medicamentos
UY27258A1 (es) Derivados de dihidro-benzo b 1, 4 diazepin-2-ona como antagonistas ii mglur2
MX9307062A (es) Derivado de quinuclidina para el tratamiento de los trastornos inflamatorios y del sistema nervioso central.
ECSP055746A (es) Antagonistas de cgrp elegidos, procedimiento para su preparación, así como su empleo como medicamentos
GT200000011A (es) Uso de acidos isoxazolcarboxilicos sustituidos y derivados y nuevos materiales.
ES2128735T3 (es) Composiciones farmaceuticas que comprenden un antagonista de opiaceos y de sales de calcio y su uso para el tratamiento de patologias en las que intervienen las endorfinas.
ES2119124T3 (es) Bencimidazoles utiles para el tratamiento de trastornos del sistema nervioso.
CR6726A (es) Compuestos azapoliciclicos condensados con arilo
ES2161290T3 (es) Derivados de quinazolina.
ECSP034796A (es) DERIVADOS DIHIDRO-BENZO[b][1,4]DIAZEPIN-2-ONA ANTAGONISTAS I MGLUR2
GT199800021A (es) Utilizacion de antagonistas de los receptores de canabinoides centrales para la preparacion de medicamentos.
GT199800046A (es) Compuestos de pirazina.
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
AR007118A1 (es) 4(3h)-quinazolinonas 2,3 disustituidas y composiciones farmaceuticas que las contienen
GT199900154A (es) Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
ES2055035T3 (es) Un proceso para la preparacion de un glicosido de antraciclina.
ES2065324T3 (es) N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.
AR028475A1 (es) Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
GT199800135A (es) 2 - aminopiridinas con sustituyentes alcoxi ramificados.
BR0208405A (pt) Compostos de diidropirimina substituìdos com ciano e seu uso para tratar doenças
AR018162A1 (es) Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica
ES2101012T3 (es) Derivados de acidos guanidinoalquilo-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.
CR6581A (es) Pirrolcarboxamidas fundido, receptores cerebrales gaba
UY26329A1 (es) Antagonistas de los receptores de vitronectina