GR900100613A - Θεραπευτικά πεπτίδια. - Google Patents

Θεραπευτικά πεπτίδια.

Info

Publication number
GR900100613A
GR900100613A GR900100613A GR900100613A GR900100613A GR 900100613 A GR900100613 A GR 900100613A GR 900100613 A GR900100613 A GR 900100613A GR 900100613 A GR900100613 A GR 900100613A GR 900100613 A GR900100613 A GR 900100613A
Authority
GR
Greece
Prior art keywords
amino acid
acid residue
peptide
active site
analog
Prior art date
Application number
GR900100613A
Other languages
English (en)
Inventor
David H Coy
Jacques-Pierre Moreau
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of GR900100613A publication Critical patent/GR900100613A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Ενα γραμμικό πεπτίδιο που είναι ένα ανάλογο (analog) της στη φύση απαντώμενης βιολογικά ενεργούς ουσίας Ρ που έχει μια δραστήρια πλευρά και μια δεσμευτική πλευρά υπεύθυνη για τη δέσμευση του ειπωμένου πεπτιδίου σ'ένα αποδέκτη σε κύτταρο- στόχο. Το ανάλογο έχει ένα μη-πεπτιδικό δεσμό αντί ενός πεπτιδικού δεσμού ανάμεσα σ'ένα αμινοξύ κατάλοιπο της ειπωμένης δραστήριας πλευράς κι ενός παρακείμενου αμινοξέος κατάλοιπου ή ένα συνθετικό, ένα β-αμινοξύ, ή γ-αμινοξύ κατάλοιπο που αντικαθιστά δύο αμινοξέα κατάλοιπα της δραστήριας πλευράς. ω
GR900100613A 1989-08-16 1990-08-16 Θεραπευτικά πεπτίδια. GR900100613A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39472789A 1989-08-16 1989-08-16

Publications (1)

Publication Number Publication Date
GR900100613A true GR900100613A (el) 1991-12-30

Family

ID=23560172

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100613A GR900100613A (el) 1989-08-16 1990-08-16 Θεραπευτικά πεπτίδια.

Country Status (15)

Country Link
EP (1) EP0438566B1 (el)
JP (1) JPH04502922A (el)
AT (1) ATE143372T1 (el)
CA (1) CA2039175A1 (el)
CZ (2) CZ285319B6 (el)
DD (1) DD298411A5 (el)
DE (1) DE69028692T2 (el)
DK (1) DK0438566T3 (el)
ES (1) ES2094160T3 (el)
GR (1) GR900100613A (el)
HU (1) HUT65465A (el)
IE (1) IE77033B1 (el)
PT (1) PT95016B (el)
SK (1) SK402890A3 (el)
WO (1) WO1991002745A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
FR2680174A1 (fr) * 1991-08-05 1993-02-12 Michelot Robert Nouveaux composes peptidiques, inhibiteurs de l'adsorption du virus hiv sur ses cellules cibles.
EP1082959A1 (en) 1991-09-20 2001-03-14 Glaxo Group Limited NK1 Antagonists for the treatment of depression
US6156725A (en) * 1996-08-16 2000-12-05 National Institute Of Immunology Drug for the treatment of cancer
US6492330B1 (en) 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
EP0835662B1 (en) * 1996-10-08 2001-11-14 National Institute of Immunology A drug for the treatment of cancer
CA2225185A1 (en) * 1997-08-11 1999-02-11 Peter K. Law Myoblast transfer therapy for relieving pain and for treating behavioral and perceptive abnormalities
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
EP2129381A1 (en) 2007-01-24 2009-12-09 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
EP2500029A4 (en) * 2009-11-11 2013-04-24 Univ Yamaguchi THERAPEUTIC AGENT FOR DISEASES OF THE STOMACH DARM TRAKTS
US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
AR128311A1 (es) * 2022-01-21 2024-04-17 Inst Pasteur De Montevideo Inmunización activa para reducir el dolor osteoarticular, neuropático y en cáncer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p
US4439360A (en) * 1981-12-22 1984-03-27 Anic S.P.A. Retro-inverso analogues of C-terminal penta and hexapeptides of Substance P
US4481139A (en) * 1983-04-13 1984-11-06 Board Of Regents, The University Of Texas System Peptide antagonists of substance P
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
EP0347802A2 (en) * 1988-06-20 1989-12-27 Merrell Dow Pharmaceuticals Inc. Neurokinin A antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p
US4439360A (en) * 1981-12-22 1984-03-27 Anic S.P.A. Retro-inverso analogues of C-terminal penta and hexapeptides of Substance P
US4481139A (en) * 1983-04-13 1984-11-06 Board Of Regents, The University Of Texas System Peptide antagonists of substance P
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
EP0347802A2 (en) * 1988-06-20 1989-12-27 Merrell Dow Pharmaceuticals Inc. Neurokinin A antagonists

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY vol. 17, no. 6, June 1988, pages G883 - G890 R.T.JENSEN ET AL 'Characterization of ability of various substance P antagonists to inhibit action of bombesin.' *
J.E.RIVIER ET AL 'PEPTIDES, Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, July 9-14, 1989, La Jolla, California, U.S.A.' 1990 , ESCOM , LEIDEN *
JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 264, no. 28, 5 October 1989, BALTIMORE US pages 16667 - 16671 J-M QIAN ET AL 'Reduced Peptide Bond pseudopeptide Analogues of Substance P' *
S.L.Harbeson et al, Synthesis and biological activity of (CH2NH) analogs of neurokinin A(4-10) *
TETRAHEDRON, (INCL. TETRAHEDRON REPORTS) vol. 44, no. 3, 1988, OXFORD GB pages 835 - 841 D.H.COY ET AL 'SOLID PHASE REDUCTIVE ALKYLATION TECHNIQUES IN ANALOGUE PEPTIDE BOND AND SIDECHAIN MODIFICATION' *

Also Published As

Publication number Publication date
SK280796B6 (sk) 2000-07-11
ATE143372T1 (de) 1996-10-15
PT95016A (pt) 1991-04-18
HU906872D0 (en) 1991-07-29
CA2039175A1 (en) 1991-02-17
IE77033B1 (en) 1997-11-19
SK402890A3 (en) 2000-07-11
DK0438566T3 (da) 1996-11-11
IE902958A1 (en) 1991-02-27
ES2094160T3 (es) 1997-01-16
DE69028692D1 (de) 1996-10-31
JPH04502922A (ja) 1992-05-28
DE69028692T2 (de) 1997-02-20
EP0438566B1 (en) 1996-09-25
CZ285562B6 (cs) 1999-09-15
WO1991002745A1 (en) 1991-03-07
PT95016B (pt) 1997-05-28
CZ285319B6 (cs) 1999-07-14
EP0438566A4 (en) 1993-03-31
CZ402890A3 (cs) 1999-04-14
HUT65465A (en) 1994-06-28
EP0438566A1 (en) 1991-07-31
DD298411A5 (de) 1992-02-20

Similar Documents

Publication Publication Date Title
ES2090140T3 (es) Peptidos terapeuticos.
EP0309297A3 (en) Therapeutic peptides
GR900100613A (el) Θεραπευτικά πεπτίδια.
HUT59420A (en) Process for producing peptides having pharmaceutical action
GB8718777D0 (en) Variants of bovine pancreatic trypsin inhibitor
Kiso et al. Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide
AU7196596A (en) Peptides and antibodies for treatment of rheumatoid arthritis
ATE129744T1 (de) Rekombinantes c-terminal alpha amidatierungsenzym von menschlischem thyroidursprung.
PT95057A (pt) Processo para a preparacao de peptidos terapeuticos
PT93320A (pt) Processo para a preparacao de peptideos terapeuticos
ATE46173T1 (de) Pharmakologisch aktive peptide.
EP0290029A3 (en) (19-alanine) calcitonin
ZA874001B (en) Functional recombinant analog polypeptides devoid of hydrophobic amino acids