GR79540B - - Google Patents

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Publication number
GR79540B
GR79540B GR75155A GR840175155A GR79540B GR 79540 B GR79540 B GR 79540B GR 75155 A GR75155 A GR 75155A GR 840175155 A GR840175155 A GR 840175155A GR 79540 B GR79540 B GR 79540B
Authority
GR
Greece
Application number
GR75155A
Inventor
Seigfried Drewes
Roelof Wilke Liebenberg
Original Assignee
Rooperol Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rooperol Nv filed Critical Rooperol Nv
Publication of GR79540B publication Critical patent/GR79540B/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/40Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
    • C07C15/42Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic
    • C07C15/48Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic the hydrocarbon substituent containing a carbon-to-carbon triple bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/40Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
    • C07C15/50Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals polycyclic non-condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/042Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/048Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/20Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/28Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486Polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR75155A 1983-06-30 1984-06-29 GR79540B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838317850A GB8317850D0 (en) 1983-06-30 1983-06-30 Rooperol and its derivatives

Publications (1)

Publication Number Publication Date
GR79540B true GR79540B (el) 1984-10-30

Family

ID=10545081

Family Applications (1)

Application Number Title Priority Date Filing Date
GR75155A GR79540B (el) 1983-06-30 1984-06-29

Country Status (18)

Country Link
US (1) US4644085A (el)
EP (1) EP0130829B1 (el)
JP (1) JPS60105637A (el)
AR (1) AR242017A1 (el)
AT (1) ATE27599T1 (el)
AU (1) AU569529B2 (el)
CA (1) CA1293735C (el)
DE (1) DE3464050D1 (el)
DK (1) DK322984A (el)
ES (1) ES8608462A1 (el)
GB (1) GB8317850D0 (el)
GR (1) GR79540B (el)
IE (1) IE57563B1 (el)
IL (1) IL72239A (el)
NO (1) NO158376C (el)
NZ (1) NZ208694A (el)
PT (1) PT78819B (el)
ZA (1) ZA844983B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317850D0 (en) * 1983-06-30 1983-08-03 Roecar Holdings Nv Rooperol and its derivatives
FR2576897B1 (fr) * 1985-02-01 1987-02-27 Centre Nat Rech Scient Nouveaux derives epoxydiques, leur preparation et leur application, notamment comme medicaments antitumoraux
EP0206765B1 (en) * 1985-06-19 1991-03-06 Rooperol (Na) Nv Process for preparation of rooperol, hypoxoside and derivatives thereof
US4956502A (en) * 1985-06-19 1990-09-11 Rooperol (N.A.) Nv Process for the preparation of rooperol derivative
MX9305453A (es) * 1992-09-07 1994-05-31 Virostat Na Nv Metodo para tratar infecciones virales.
US5569649A (en) * 1994-06-14 1996-10-29 Phytopharm (Na) N.V. Anti-inflammatory treatment method
CN104513137B (zh) * 2014-12-22 2016-05-04 陕西师范大学 一种1,5-烯炔醇类化合物及其合成方法和应用
CN109704926B (zh) * 2019-01-29 2022-02-08 南京工业大学 抗癌活性分子骨架1,4-烯炔类化合物及其制备方法与应用
WO2023036995A1 (en) * 2021-09-13 2023-03-16 Centre National De La Recherche Scientifique Alkynylcarbinols with high cytotoxicity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE750532A (fr) * 1969-05-26 1970-10-16 Lilly Co Eli Nouveaux diethynylcarbinols substitues
US3922266A (en) * 1972-06-28 1975-11-25 Sumitomo Chemical Co Aryl ketones and production thereof
US4224244A (en) * 1973-03-30 1980-09-23 Hoffmann-La Roche Inc. 9-Phenyl 5,6-dimethyl-nona-2,4,6,8 tetraenal or tetraenol derivatives
IT1022545B (it) * 1973-10-01 1978-04-20 Hoffmann La Roche Procedimento per fabricare etinilcarbinoli
US4055575A (en) * 1975-03-20 1977-10-25 Scm Corporation Synthesis of dehydrophytol and vitamin E
US4162265A (en) * 1978-09-27 1979-07-24 The United States Of America As Represented By The Secretary Of The Air Force Aromatic enyne compounds and their synthesis
US4223172A (en) * 1978-12-07 1980-09-16 Gulf Research & Development Company Process for the preparation of bromoarylacetylene and aryldiacetylene precursors
CH642936A5 (de) * 1979-10-19 1984-05-15 Hoffmann La Roche Aethinylierung alpha,beta-ungesaettigter ketone.
US4345084A (en) * 1981-06-29 1982-08-17 Hoffmann-La Roche Inc. Unsaturated eicosanoic acids
GB2120650A (en) * 1982-04-19 1983-12-07 Roecar Holdings Nv Rooperol derivatives
CA1209912A (en) * 1982-04-19 1986-08-19 Siegfrid Drewes Extract of plants of the family of hypoxidaceae for treatment of cancer
GB8317850D0 (en) * 1983-06-30 1983-08-03 Roecar Holdings Nv Rooperol and its derivatives

Also Published As

Publication number Publication date
IL72239A (en) 1989-07-31
AU2992184A (en) 1985-01-03
GB8317850D0 (en) 1983-08-03
IL72239A0 (en) 1984-10-31
AR242017A1 (es) 1993-02-26
CA1293735C (en) 1991-12-31
IE841653L (en) 1984-12-30
EP0130829A3 (en) 1985-03-06
PT78819B (en) 1986-06-18
JPS60105637A (ja) 1985-06-11
PT78819A (en) 1984-07-01
ES533884A0 (es) 1986-04-01
NO158376C (no) 1988-08-31
ZA844983B (en) 1985-02-27
DE3464050D1 (en) 1987-07-09
AU569529B2 (en) 1988-02-04
EP0130829B1 (en) 1987-06-03
IE57563B1 (en) 1992-12-16
NZ208694A (en) 1988-09-29
NO158376B (no) 1988-05-24
ATE27599T1 (de) 1987-06-15
DK322984A (da) 1984-12-31
ES8608462A1 (es) 1986-04-01
US4644085A (en) 1987-02-17
DK322984D0 (da) 1984-06-29
NO842604L (no) 1985-01-02
EP0130829A2 (en) 1985-01-09

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