GR36824B - METHOD FOR THE MANUFACTURE OF PIPERIDINE PRODUCERS. - Google Patents

METHOD FOR THE MANUFACTURE OF PIPERIDINE PRODUCERS.

Info

Publication number
GR36824B
GR36824B GR670136824A GR670136824A GR36824B GR 36824 B GR36824 B GR 36824B GR 670136824 A GR670136824 A GR 670136824A GR 670136824 A GR670136824 A GR 670136824A GR 36824 B GR36824 B GR 36824B
Authority
GR
Greece
Prior art keywords
alkyl
general formula
formula
compound
hydrogen
Prior art date
Application number
GR670136824A
Other languages
Greek (el)
Original Assignee
F. Hoffmann - La Roche & Co Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche & Co Aktiengesellschaft filed Critical F. Hoffmann - La Roche & Co Aktiengesellschaft
Publication of GR36824B publication Critical patent/GR36824B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

έθοδος παρασκευής νέων παραγώγων πιπεριδίνης του γενικού τύπου [*] Ι εις τον οποίον σημαίνουν Χ αλογόνον ως φθόριον, χλώριον, βρώμιον ή ιώδιον. R1 υδρογόνον, κατώτερον αλκύλιον, κυκλο-κατώτερον-αλκύλιον,κυκλο-κατώτερον-αλκύλιον-κατώτερον-αλκύλιον, υδροξυ-κατώτερον-αλκύλιον, ή αλκοξυ-κατώτερον-αλκύλιονκαι R2 υδρογόνον ή ακύλιον, και των αλάτων αυτών,εκ τούτου χαρακτηριζομένη, ότι συμπυκνούμεν έν παράγωγον πιπεριδίνης του γενικού τύπου [*] ΙΙ εις τον οποίον R1 έχει την ως άνω σημασίαν, μεθ'ενός παραγώγου βουτυροφαινόνης του γενικού τύπου [*] ΙΙΙ εις τον οποίον Χ έχει την ανωτέρω σημασίαν και Υ παριστά μίαν εξερχομένην (δυναμένην ν'αποσπασθή) ομάδα, ότι φέρομεν εις αντίδρασιν μίαν ούτω ληφθείσαν ένωσιν του τύπου Ι, εις τον οποίον R2 σημαίνει υδρογόνον, κατά γνωστόν ενδεχομένως τρόπον μεθ'ενός μέσου ακυλιώσεως, ότι μετατρέπομεν, αν επιθυμούμεν, μίαν ένωσιν του τύπου Ι, εις τον οποίον R1 σημαίνει μίαν κατώτερον-αλκοξυ-κατώτερον-αλκυλιον-ομάδα, κατά γνωστόν καθ'εαυτόν τρόπον, εις μίαν ένωσιν του τύπου Ι, εις τον οποίον R1 σημαίνει μίαν υδροξ-κατώτερον-αλκύλιον-ομάδα και ότι μετατρέπομεν, αν επιθυμούμεν, μίαν ούτω ληφθείσαν βάσιν του γενικού τύπου Ι εις έν άλας. method of preparing novel piperidine derivatives of the general formula [*] Ι in which they mean X halogen as fluorine, chlorine, bromine or iodine. R 1 hydrogen, lower alkyl, cyclo-lower-alkyl, cyclo-lower-alkyl-lower-alkyl, hydroxy-lower-alkyl, or alkoxy-lower-alkyl and R 2 hydrogen or acyl, and of these salts, therefore characterized in that they are concentrated in a piperidine derivative of the general formula [*] II wherein R 1 has the above meaning, with a butyrophenone derivative of the general formula [*] III in which X has the above meaning and Y represents an outgoing (detachable) group, Reacting a compound of formula I thereof, in which R2 means hydrogen, in a possibly known manner by means of an acylating agent, is converted, if desired, to a compound of formula I, wherein R1 denotes a lower a lower alkyl group, as known in the art, in a compound of formula I, wherein R1 denotes a hydroxy-lower alkyl group and is converted, if desired, thus obtained on the basis of general formula I to in salt.

GR670136824A 1966-07-11 1967-07-08 METHOD FOR THE MANUFACTURE OF PIPERIDINE PRODUCERS. GR36824B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56396266A 1966-07-11 1966-07-11

Publications (1)

Publication Number Publication Date
GR36824B true GR36824B (en) 1969-03-12

Family

ID=24252613

Family Applications (1)

Application Number Title Priority Date Filing Date
GR670136824A GR36824B (en) 1966-07-11 1967-07-08 METHOD FOR THE MANUFACTURE OF PIPERIDINE PRODUCERS.

Country Status (7)

Country Link
BE (1) BE701114A (en)
DE (1) DE1695194A1 (en)
ES (1) ES342860A1 (en)
FR (1) FR7229M (en)
GB (1) GB1131534A (en)
GR (1) GR36824B (en)
NL (1) NL6709605A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52216C (en) * 1969-07-16 1977-07-11 Sumitomo Chemical Co Process for the preparation of gamma-piperidinobutyrophenone derivatives.
JPS568318A (en) * 1979-06-28 1981-01-28 Janssen Pharmaceutica Nv Non oral long acting composition of haloperidol and bromperidol derivative
GB8621892D0 (en) * 1986-09-11 1986-10-15 Lundbeck & Co As H Organic compound

Also Published As

Publication number Publication date
GB1131534A (en) 1968-10-23
FR7229M (en) 1969-09-01
ES342860A1 (en) 1968-09-01
DE1695194A1 (en) 1971-03-18
BE701114A (en) 1968-01-10
NL6709605A (en) 1968-01-12

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